RESUMO
Herein, we report the evaluation of dextran (DXT) derivatives bearing hydrophobic or hydrophilic functional groups as stabilisers of oil-in-water (O/W) emulsions. All investigated modifications conferred interfacial activity to produce stable O/W emulsions, methacrylate(MA)-functionalised DXT being the most promising stabiliser. A minimum amount of MA was required to obtain stable O/W nanoemulsions, which could be degraded in the presence of lipases.
Assuntos
Dextranos/metabolismo , Proteínas Fúngicas/metabolismo , Lipase/metabolismo , Nanopartículas/metabolismo , Óleos/metabolismo , Água/metabolismo , Dextranos/química , Emulsões/química , Emulsões/metabolismo , Proteínas Fúngicas/química , Interações Hidrofóbicas e Hidrofílicas , Lipase/química , Nanopartículas/química , Óleos/química , Tamanho da Partícula , Água/químicaRESUMO
Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.
