A blinded validation of the Swedish version of the Clinical Assessment Interview for Negative Symptoms (CAINS).

PURPOSE: The Clinical Assessment Interview for Negative Symptoms (CAINS) was developed in order to advance the assessment of negative symptoms. The aim of this study was to validate the Swedish version of the CAINS. MATERIALS AND METHODS: Thirty-four out-patients with a schizophrenia spectrum disorder were recruited. All patients were videotaped while interviewed with the CAINS and the Brief Psychiatric Rating Scale (BPRS). Another rater watched the video recordings in the reverse order, enabling a blinded design. The patients also filled in self-reported measures of depression, quality of life, and social and vocational functioning. We calculated inter-rater agreement and internal consistency for the CAINS. We also calculated validity measures by correlating the subscales Motivation and Pleasure (CAINS-MAP) and Expression (CAINS-EXP) to subscales of the BPRS. RESULTS: The blinded inter-rater agreement for the CAINS total score was high (ICC = 0.92) but slightly lower for the expression subscale (ICC = 0.76). Cronbach's alpha was 0.84 for the total score. Convergent validity with the negative symptoms subscale of BPRS was different for the blinded and the unblinded data, with a CAINS-MAP correlation of 0.10 (p = 0.580) and a CAINS-EXP correlation of 0.48 (p = 0.004) in the blinded data. The unblinded data had a CAINS-MAP correlation of 0.38 (p = 0.026) and a CAINS-EXP correlation of 0.87 (p < 0.001). Self-rated measures of anhedonia correlated to CAINS-MAP with a coefficient of 0.68 (p < 0.001), while the CAINS-EXP only had a correlation of 0.16 (p = 0.366) to these measures. CONCLUSION: The Swedish version of the CAINS displays adequate psychometric properties in line with earlier validation studies.

From LTL to rLTL monitoring: improved monitorability through robust semantics.

Runtime monitoring is commonly used to detect the violation of desired properties in safety critical cyber-physical systems by observing its executions. Bauer et al. introduced an influential framework for monitoring Linear Temporal Logic (LTL) properties based on a three-valued semantics for a finite execution: the formula is already satisfied by the given execution, it is already violated, or it is still undetermined, i.e., it can still be satisfied and violated by appropriate extensions of the given execution. However, a wide range of formulas are not monitorable under this approach, meaning that there are executions for which satisfaction and violation will always remain undetermined no matter how it is extended. In particular, Bauer et al. report that 44% of the formulas they consider in their experiments fall into this category. Recently, a robust semantics for LTL was introduced to capture different degrees by which a property can be violated. In this paper we introduce a robust semantics for finite strings and show its potential in monitoring: every formula considered by Bauer et al. is monitorable under our approach. Furthermore, we discuss which properties that come naturally in LTL monitoring-such as the realizability of all truth values-can be transferred to the robust setting. We show that LTL formulas with robust semantics can be monitored by deterministic automata, and provide tight bounds on the size of the constructed automaton. Lastly, we report on a prototype implementation and compare it to the LTL monitor of Bauer et al. on a sample of examples.

Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid.

BACKGROUND: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia. METHODS: Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated. RESULTS: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05). CONCLUSION: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels.