[COMPLEX ASSESSMENT OF ENVIRONMENTAL FACTORS AND POSTVACCINAL IMMUNE STATE].

This article was written on the base of the analysis of data of protocols of annual serological sturdies of the post-vaccination immunity status in indicator groups of populations, the analysis of samples of drinking water air and soil with the assessment of the socio-economic development of mono-towns and rural settlements. In the article there is reflected the comprehensive assessment of environmental factors and specific features of the formation of socio-economic conditions of rural communities and mono towns. There was performed a comparative assessment of the status of post-vaccination immunity to infections controlled by specific means of prevention, in different age groups in mono towns and rural settlements. There was established a dependence of the formation of post-vaccination immunity on the state of environmental factors.

[Human health risk upon air exposure to chemicals in enclosed spaces and residential areas of an industrial town].

The study determined priority chemicals in the ambient air and air of enclosed spaces of the town's administrative districts, by taking into account the formation of a community health risk. The industrial town's areas were ranked by the hazard of carcinogenic and non-carcinogenic effects caused by the varying intraenvironmental distribution of substances. The distribution of pollutants in the study areas with varying anthropogenic exposures allows one to consider suspended matter, cadmium, nickel, and formaldehyde in the air of residential areas and formaldehyde, phenol, and suspended matter in the air of enclosed spaces as universal markers of exposure for dwelling environmental factors in the identification of toxicants and in the assessment of community health risk within the framework of sociohygienic monitoring and as indicators for the assessment of the immediate and final results of purpose-oriented departmental programs.

[Assessment of human health risk upon acute inhalational exposure to chemical substances].

To provide the safety of the population and environment with the occurrence of man-caused catastrophes due their increase is now an urgent problem. Toxic hazard coefficients were calculated for hydrogen sulfide in the settlements located in a possible chemical pollution area in the Orenburg gas-chemical complex. Assessment of the hazard of toxic effects to the population upon exposure to hydrogen sulfide has indicated that there may be toxic effects in the inhabitants of the study nearby inhabited localities. The findings do not characterize the possible severity of intoxication so it is necessary to develop a system of criteria for the differentiation of the severity of negative effects in order to evaluate the hazard of acute chemical exposures.

[Free radical oxidation in the assessment of health risk].

Aliovalent metals (d-metals, such as manganese, nickel, iron, copper, chromium, etc.) which are able to change the degree of oxidation, to activate free radical oxidative processes, and to initiate the development of the condition that is currently defined as oxidative stress soundly and which are diagnostic criteria in the prenosological assessment of health risks are prominent among other priority ambient air pollutants. The findings suggest that there is a direct relationship between the calculated indices characterizing the carcinogenic and noncarcinogenic effects, the risk of oxidative stress, the environmental availability of prooxidants, mainly d-elements (manganese, nickel, copper, zinc) and the actual values of an increase in the rate of lipid peroxidation, of a decrease in antioxidative activity, and of an elevation in the level of methemoglobin formation.