RESUMO
INTRODUCTION: Complications in arthroplasty are mostly attributed to wear particle related loosening, infections or mechanical failure. There is no investigation in a large patient series giving data about the frequency of allergic reactions to metals or bone cement components in arthroplasty with complications. METHODS: In 92 patients with cemented hip or knee arthroplasty (66 patients with complications, 26 without symptoms) patch testing and medical history were evaluated. Contact allergy rates to metals and potential bone cement components were analyzed as well as type of complaints and allergy history. RESULTS: Main complaints were pain (81.8%), reduced range of motion (54.5%) and local swelling (56.1%). Contact allergy to nickel was shown in 16/66 patients (24.2%), 6.1% were allergic to cobalt and 3.0% to chromium. 21/66 patients (31.8%) showed an allergic reaction to bone cement components (gentamicin 23.8%, benzoyl peroxide 10.6%, hydroquinone 4.5%). Sensitization rates in patients without symptoms were 3.8% to nickel as well as to cobalt and chromium, and 15.4% to gentamicin. CONCLUSION: Contact allergy rates to metals and potential bone cement components are higher in arthroplasty patients with complications than in the general population.
Assuntos
Cimentos Ósseos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Prótese de Quadril/efeitos adversos , Prótese do Joelho/efeitos adversos , Metais/efeitos adversos , Complicações Pós-Operatórias/diagnóstico , Falha de Prótese , Adulto , Idoso , Idoso de 80 Anos ou mais , Peróxido de Benzoíla/efeitos adversos , Cromo/efeitos adversos , Cobalto/efeitos adversos , Feminino , Gentamicinas/efeitos adversos , Humanos , Hidroquinonas/efeitos adversos , Masculino , Pessoa de Meia-Idade , Níquel/efeitos adversos , Testes do EmplastroRESUMO
SUMMARY: Searches for variable motifs such as protein-binding sites or promoter regions are more complex than the search for casual motifs. For example, in amino acid sequences comparing motifs alone mostly proves to be insufficient to detect regions that represent proteins with a special function, because the function depends on biochemical properties of individual amino acids (such as polarity or hydrophobicity). Pure string matching programs are not able to find these motifs; hence, we developed ParSeq, a program that combines the search for motifs with certain structural properties, the verification of biochemical properties, an approximate search mechanism and a stepwise creation of the motif description by allowing to search on previously obtained results. AVAILABILITY: http://www-pr.informatik.uni-tuebingen.de/parseq
