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1.
Zentralbl Bakteriol Mikrobiol Hyg A ; 260(4): 443-7, 1985 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-3834718

RESUMO

Oligomer 12 S alpha-toxin as well as 3 S alpha-toxoid of Staphylococcus aureus induced the formation of monoclonal antibodies (mabs). Mabs against the 12 S alpha-toxin could be demonstrated in 31 and those against 3 S alpha-toxoid in 18 of 120 hybrid cell colonies. Each of these mab-preparations reacted with 12 S, 3 S alpha-toxin and 3 S alpha-toxoid. The reactions were more pronounced with the homologous than the heterologous toxin preparations. Mabs against 12 S alpha-toxin inhibited the hemolytic effects of native 3 S alpha-toxin as well or better than the respective polyclonal antisera.


Assuntos
Anticorpos Monoclonais , Toxinas Bacterianas/farmacologia , Proteínas Hemolisinas , Hemólise/efeitos dos fármacos , Animais , Complexo Antígeno-Anticorpo , Toxinas Bacterianas/imunologia , Toxinas Bacterianas/isolamento & purificação , Hibridomas/imunologia , Cinética , Camundongos , Staphylococcus aureus/análise
4.
Zentralbl Bakteriol A ; 247(2): 164-9, 1980.
Artigo em Alemão | MEDLINE | ID: mdl-6158814

RESUMO

Concentrations of alpha 2-macroglobulin could be determined in the sera of 215 blood donors and 94 patients with various internal diseases by quantitative inhibition of an acid protease from Staphylococcus aureus, M 135 (fig. 1, 2). The determinations agreed closely with those obtained by immunodiffusion (tab. 1, fig. 3). However, the alpha 2-macroglobulin-measurements by the protease method required only 4 h and 40 microliter serum. This procedure would also be suitable for the determination of alpha 2-macroglobulin in sera from experimental and domestic animals.


Assuntos
Inibidores de Proteases , alfa-Macroglobulinas/análise , Humanos , Imunodifusão , Staphylococcus aureus/enzimologia , alfa-Macroglobulinas/farmacologia
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