Extracorporeal Irradiation in Malignant Bone Tumors.

Extracorporeal irradiation (ECI) is relatively a rare method used in the management of malignant bone tumors (MBT). It consists of en block removal of the tumor bearing bone segment, removal of the tumor from the bone, irradiation and re implantation back in the body.

An assessment of the impacts of the REDD+ pilot project on community forests user groups (CFUGs) and their community forests in Nepal.

REDD+ has the potential to reduce greenhouse gas emissions, meet climate stabilisation targets and protect biological diversity. Consequently, millions of dollars are being channelled into developing countries rich in forests, for pilot projects that will provide data for the design of REDD+ projects that are based on incentives and performance. This paper evaluates the impacts of REDD+ pilot projects on community forests and associated user groups (CFUGs) in Nepal. A field study targeted eight CFUGs that participated in a REDD+ pilot project funded by the Forest Carbon Trust Fund in Nepal. The pilot project increased the participation of Dalit, Indigenous people, women and the poor, and was able to provide some social safeguards. However, when all the additional costs and foregone benefits of the project are considered, REDD+ is not an attractive market-based option for Nepalese CFUGs. A better approach would be a bilateral or multilateral approach that is not market based, but provides incentives beyond environmental and social safeguards. The results of this study will be useful in designing REDD+ policies and programmes for community forest-based REDD+ stakeholders in developing countries.

The core control system of intracellular iron homeostasis: a mathematical model.

Iron is a metal essential for cellular metabolism. However, excess iron available for reactions contributes to the formation of dangerous reactive oxygen species, such as the hydroxyl radical, via the Fenton reaction. Therefore, intracellular iron levels are tightly constrained by a control system of proteins. This paper contains a mathematical model, in the form of a system of five ordinary differential equations, of the core of this control system, including the labile iron pool as well as proteins that regulate uptake, storage, and export and are connected through negative feedback loops. The model is validated using data from an overexpression experiment with cultured human breast epithelial cells. The parameters in the mathematical model are not known for this particular cell culture system, so the analysis of the model was done for a generic choice of parameters. Through a mixture of analytical arguments and extensive simulations it is shown that for any choice of parameters the model reaches a unique stable steady state, thereby ruling out oscillatory behavior. It is shown furthermore that the model parameters are identifiable through suitable experiments.