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Growth ; 42(2): 213-23, 1978 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-98392

RESUMO

An aqueous alcoholic extract of fresh flowers of Yucca glauca Nutt. showed striking antitumor activity against B16 melanoma in mice. Systematic fractionation of the extract by means of solvent extraction and gel permeation chromatography led to separation of two galactose containing polysaccharide fractions with marked inhibitory activity against B16 melanoma in mice. The extraction, fractionation, purification and preliminary characterization of the active polysaccharide fractions are described. The materials showed no activity against L1210 or P388 leukemias in mice. The implications of the findings for searches for both natural and synthetic anticancer agents are discussed.


Assuntos
Antineoplásicos , Extratos Vegetais/farmacologia , Polissacarídeos/farmacologia , Animais , Fracionamento Químico/métodos , Cromatografia em Papel , Imunodifusão/métodos , Leucemia L1210/tratamento farmacológico , Leucemia Experimental/tratamento farmacológico , Melanoma/tratamento farmacológico , Camundongos , Neoplasias Experimentais/tratamento farmacológico , Extratos Vegetais/análise , Plantas/análise
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