Thermoelectric Transport in a Three-Channel Charge Kondo Circuit.

We theoretically investigate the thermoelectric transport through a circuit implementation of the three-channel charge Kondo model quantum simulator [Z. Iftikhar et al., Science 360, 1315 (2018)SCIEAS0036-807510.1126/science.aan5592]. The universal temperature scaling law of the Seebeck coefficient is computed perturbatively approaching the non-Fermi liquid strong coupling fixed point using the Abelian bosonization technique. The predicted T^{1/3}logT scaling behavior of the thermoelectric power sheds light on the properties of Z_{3} emerging parafermions and gives access to exploring prefractionalized zero modes in the quantum transport experiments. We discuss a generalization of approach for investigating a multichannel Kondo problem with emergent Z_{N}→Z_{M} crossovers between "weak" non-Fermi liquid regimes corresponding to different low-temperature fixed points.

Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting.

OBJECTIVE: Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach. APPROACH: The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats. MAIN RESULTS: Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals. SIGNIFICANCE: A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online.

Sequencing-based typing identifies three new HLA alleles: C*02:29, C*06:29 and DQB1*03:24.

Two new HLA-C alleles, C*02:29 and C*06:29, and one new HLA-DQB1 allele, DQB1*03:24, are described.

[HLA and transfusion: new approaches with Luminex™ technology]. / HLA et transfusion: nouvelles approches à l'ère du Luminex™.

The major histocompatibility complex is a multigenic system highly polymorphic coding for human leukocyte antigen (HLA) molecules, which are the strongest antigens for immune response and play a major role in allograft rejection. Class I antigens are expressed on almost all nucleated cells and platelets, whereas HLA class II antigens are mostly on antigen presenting cells. During transfusion, anti-HLA antibodies can induce transfusion incidents like fever, transfusion-related acute lung injury TRALI and refractoriness to the platelets transfusion. Identification of HLA class I antibodies is very important to find HLA compatible platelets concentrates. Since the end of 1960s, the complement-dependent microlymphocytotoxicity assay has been the standard internationally recognized method for cross matching and screening of HLA antibodies. It became necessary to improve the test sensitivity because some clinical relevant antibodies were not detected. Sensitive methods appeared in the 1990 s: flow cytometry, enzyme-linked immunosorbent assay and now Luminex™. This latter is the most sensitive method with single HLA antigen panel assays to generate the most informative reactivity pattern of antibodies. The high sensitivity and specificity of the Luminex™ technology performed to screen HLA antibodies allows the best selection of platelets donors. When no compatible concentrates are available for highly immunized recipients, the cross-matching method could be used to select a platelet concentrate.