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2.
Sci Rep ; 10(1): 9642, 2020 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-32541669

RESUMO

Central composite design (CCD) was applied to optimize the synthesis condition of silver nanoparticles (AgNPs) using the extract of Plantago major (P. major) seeds via a low cost and single-step process. The aqueous seed extract was applied as both reducing element and capping reagent for green production of AgNPs. Five empirical factors of synthesis including temperature (Temp), pH, volume of P. major extract (Vex), volume of AgNO3 solution (VAg) and synthesis time were used as independent variables of model and peak intensity of Surface Plasmon Resonance (SPR) originated from NPs as the dependent variable. The predicted optimal conditions was determined to be: Temp = 55 °C, pH = 9.9,Vex = 1.5 mL, VAg = 30 mL, time = 60 min. The characterization of the prepared AgNPs at these optimum conditions was conducted by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM) and X-ray diffraction (XRD) to determine the surface bio-functionalities. Bio-activity of these AgNPs against bacteria and fungi were evaluated based on its assay against Micrococcus luteus, Escherichia coli and Penicillium digitatum. Furthermore, antioxidant capacity of these NPs was checked using the ferric reducing antioxidant power (FRAP) assay.


Assuntos
Antibacterianos/farmacologia , Antifúngicos/farmacologia , Antioxidantes/farmacologia , Nanopartículas Metálicas , Extratos Vegetais , Plantago/química , Prata , Antibacterianos/química , Antifúngicos/química , Antioxidantes/química , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Concentração de Íons de Hidrogênio , Nanopartículas Metálicas/química , Nanopartículas Metálicas/ultraestrutura , Microscopia Eletrônica de Varredura , Microscopia Eletrônica de Transmissão , Sementes/química , Ressonância de Plasmônio de Superfície , Temperatura
3.
Nanomedicine (Lond) ; 15(15): 1501-1512, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32378459

RESUMO

Nanotechnology and nanomedicine have excellent potential in dealing with a range of different health problems, including viruses, which are considered to be a serious challenge in the medical field. Application of nanobiotechnology could represent a new avenue for the treatment or disinfection of viruses. There is increasing concern regarding the control of coronaviruses, among these, Middle East respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus-2 are well known and dangerous examples. This article aims to provide an overview of recent studies on the effectiveness of nanoparticles as diagnostic or antiviral tools against coronaviruses. The possibilities of effectively using nanomaterials as vaccines and nanosensors in this field are also presented.


Assuntos
Antivirais/uso terapêutico , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/terapia , Nanopartículas/uso terapêutico , Animais , Antivirais/análise , Técnicas Biossensoriais/métodos , COVID-19 , Coronavirus/efeitos dos fármacos , Coronavirus/isolamento & purificação , Infecções por Coronavirus/prevenção & controle , Humanos , Nanomedicina/métodos , Nanopartículas/análise , Nanotecnologia/métodos , Pandemias/prevenção & controle , Pneumonia Viral/diagnóstico , Pneumonia Viral/prevenção & controle , Pneumonia Viral/terapia
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