[The assessment of the course of an infectious process by the membrane status of the peripheral blood lymphocytes]. / Otsenka techeniia infektsionnogo protsessa po sostoianiiu membran limfotsitov perifericheskoi krovi.

Lipid peroxidation in lymphocyte membranes is studied in patients with acute viral hepatitis B and B + C and in chronic alcoholics with Flexner's dysentery and with uneventful premorbid history. The intensity of lipid peroxidation in lymphocytes was increased, corresponding to the severity and period of infection. The premorbid background and therapy influenced the lymphocyte membrane status, which can serve as an integral indicator of immunological reactivity of the organism.

[Intensity of the peroxidation of membrane lipids and metabolism of lymphocytes in viral hepatitis patients]. / Intensivnost' perekisnogo okisleniia lipidov membran i metabolizm limfotsitov u bol'nykh virusnymi gepatitami.

Patients with acute viral hepatitis B were found to have an increase in the processes of peroxidization of lymphocyte membrane lipids and in the activity of superoxide dismutase, an antioxidant enzyme, depending on the period of the disease and its severity. Patients with a severe form of the disease were found to have specific features of the intracellular metabolism of lymphocytes in comparison with patients having moderate forms of the disease. To a lesser degree, the characteristics of lymphocytes in hepatitis cases depended of the etiology of the disease, caused by hepatitis virus B, C or the combination of both. The properties of lymphocytes were found to reflect the immune reactiveness of the body and could be used for evaluating the severity of the disease, prognostication and the achievement of convalescence.

[Characteristics of viral hepatitis in addicts with consideration of lymphocyte membrane condition]. / Kharakteristika virusnykh gepatitiov u narkomanov s uchetom sostoianiiamembran limfotsitov.

AIM: To study changes in the condition of lymphocyte membranes of patients with acute viral hepatitis B (AVHB) in narcotic addicts. MATERIALS AND METHODS: 136 patients with AVHB have been examined for endogenic intoxication (plasma levels of middle-size molecular peptides, urine levels of red cells). 74% of the examinees had practiced parenteral injections of opium substitutes. Measurements were made of lymphocyte levels of malonic dialdehyde and superoxide dismutase activity characterizing free radical lipid peroxidation, enzymes of the main metabolic cycles. RESULTS: AVHB addicts often display antibodies to hepatitis C virus, high indices of endogenic intoxication. CONCLUSION: Viral hepatitis was associated with enhanced intensity of lymphocyte membrane lipid peroxidation correlating with the disease severity and duration irrespective of concomitant drug addiction. Early convalescence in drug addicts ran with persisting metabolic disturbances in the immunocompetent cells. This is a pathogenetic sign of the disease transformation to the chronic form.