[Regional differentiation of demographic dynamics in Russia and the role of healthcare].

The article examines the role of the processes of natural and migration movement of the population in changing the total population of the regions of Russia for more than two decades of the XXI century. Six possible combinations of these processes are proposed, which result in either an overall increase in the population or a reduction. During the period under review, various scenarios in a number of regions had fairly stable trends - a constant decline in the population or a stable increase in it. Moreover, such stability was determined either by a stable natural increase exceeding the migration decline, or by a stable decrease in the population as a result of a stable natural decline or migration outflow. But many regions experienced both the turbulence of reproduction and migration processes, as a result of which the overall result for population dynamics also changed. For the first time, a typology of Russian regions was carried out according to the frequency of the influence of natural and migration growth on the total population of the regions. This allowed further studies to consider the role of migration processes on the demographic aging of the population of the regions.

[The demographic aging of population: regional trends in Russia].

The article considers evolution of research and views on challenges and menaces of demographic aging process in the works of national and foreign scientists. The characteristics of this process in regions of the Russian Federation consist in special diversity of social economic, climatic, geographical and mental conditions in which demographic processes proceed. This determined availability of various types and stages of demographic aging in regions of the Russian Federation as well as opportunities to temper negative consequences of this process.

KNOWLEDGE RELATED TO THE NOVEL CORONAVIRUS (SARS-COV-2) AMONG GEORGIAN POPULATION.

Georgia confirmed its first case of SARS-COV-2 infection on February 26, 2020. Despite the government's proactive measures during the early stages of the epidemic, number of new infections of SARS-COV-2 is increasing and by March 31, a total of 110 cases have been reported. Limited understanding about epidemics can lead to panic and disrupt public health efforts to contain transmission. Thus, it is very important to understand the perceptions of the population regarding the disease and perceived level of government preparedness to fight against the spread of infection. This study reports results of a survey designed to understand attitudes and knowledge regarding SARS-COV-2 virus among Georgian population, including health care workers (HCWs). The online survey was conducted using a Facebook advertisement. The target was the whole country and the language used was Georgian. We collected information on demographic data, knowledge of symptoms and transmission modes of coronavirus, perceived differences between coronavirus and influenza, availability of antiviral medication and vaccination. We also included questions to capture the Georgian population's perceptions about government preparedness to combat the new coronavirus. The survey was open for three days (March 2-4, 2020). 5228 participants completed the survey. Of these, 40.3% were 25-45 years old and 58.2% were female. 20.7% of respondents had university degree and 10.3% were HCWs. For 25.8% of respondents, COVID-19 and influenza are the same diseases; 10.9% did not know if they are different. The majority correctly identified the transmission route and symptoms (96.9% and 98.0%, respectively). Regarding physical distancing, 13.2% indicated they would attend public events if needed even if they had COVID-19 symptoms. 19.1% think that Georgia is ready for COVID 19 epidemic, while according to 55% the county is not ready, but HCWs are trying hard to respond to this challenge properly. For 18% response is inadequate. There was no difference in knowledge between HCWs, non-HCWs and unemployed. 20% of HCWs as well as other study subjects believe that SARS-COV-2 vaccine and medications do exist but are simply not available in Georgia. One in five Georgians believe that there is a vaccine and medication to treat coronavirus, but that it is not available in the country. Given that information regarding coronavirus is changing very rapidly, the need to reach people with time-sensitive educational messages as well as prevention strategies is vital. Three months have elapsed since discovery of the novel coronavirus causing severe acute respiratory syndrome and classified as SARS-COV-2.

[Efficiency of treatment methods of the patients with small-cell lung carcinoma].

With the use of multivariational statistical analysis of 185 patients with small cell lung carcinoma has been established that median survival (in months), and 1-year and 3-year survival rates (in percentage) of the patients are 9.4+/-2.6, 41.6+/-2.4 and 41.6+/-2.4, respectively. Most of patients died within the year from clinical manifestation of the disease. It has been ascertained that individual treatment methods in many aspects define prognosis of the disease. After combined treatment (radio-chemotherapy) prognosis is better. 1-year survival rate in percentage is 58.6+/-4.8 in such cases, 3-year survival rate is equal to 12.3+/-7.2 and median survival is 11.2+/-4.7 months (p<0.05). It has been shown that of all chemotherapy schemes CDE (cisplatin, doxorubicin, etoposide) is more effective. 1-year and 3-year survival rates of the patients treated with the use of this scheme were statistically reliably better in comparison with those treated with the use of other chemotherapy schemes (p<0.05). Thus, at the resistance of a tumor to chemotherapy drugs and in case of development of a recurrent tumor, in order to reach complete remission or its consolidation it is reasonable to use combination of these preparations. Results of observation should be taken into account for the evaluation of the prognosis and the choice of most effective treatment method.