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1.
J Obstet Gynaecol Res ; 41(4): 540-50, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25370989

RESUMO

AIM: Diminished vasodilator activity during pregnancy, which augments vascular responses to vasoconstrictors, is one reason for the onset of pre-eclampsia and superimposed pre-eclampsia. It is known that Dahl salt-sensitive (Dahl-S) rats develop salt-sensitive hypertension like African-Americans. The present study attempted to assess the changes and the interactions of the NOS-NO-sGC-cGMP and NP-NPR-cGMP systems in the hypertensive placenta using Dahl-S rats as an animal model of superimposed pre-eclampsia. MATERIAL AND METHODS: Pregnant Dahl-S rats were fed a high-salt diet to induce the development of hypertension and fetal growth restriction. Using these rats, we investigated the regulation of these two vasodilatation systems, including the kinetics of cyclic guanosine monophosphate (cGMP), soluble guanylate cyclase (sGC), endothelial nitric oxide synthase (NOS), cytokine-inducible NOS, natriuretic peptides (NP) (atrial NP, brain NP and C-type NP), and NP receptors (NPR) (NPR-A, NPR-B, NPR-C). RESULTS: Dahl-S rats fed a high-salt diet exhibited hypertension, fetal growth restriction and thickening of the walls in decidual vessels. The placental cGMP level in the rats fed the high-salt diet was significantly decreased compared with that in controls. The expression levels of endothelial NOS and cytokine-inducible NOS mRNA increased significantly, while that of sGCα2-sunbnit declined significantly. Messenger RNA levels of NPR-C, a clearance-type receptor of NP, declined significantly, whereas those of NP and their functional receptors NPR-A and NPR-B were unchanged. CONCLUSIONS: As Dahl-S rats with excess salt-loading during pregnancy exhibited pathological changes similar to those observed in female humans with pre-eclampsia/superimposed pre-eclampsia, this rat could be useful as an animal model of superimposed pre-eclampsia. In the placentas of hypertensive Dahl-S rats, vasodilatation seemed to be disturbed by the deregulation of both the NO-sGC-cGMP and NP-NPR-cGMP systems.


Assuntos
GMP Cíclico/metabolismo , Óxido Nítrico/metabolismo , Placenta/metabolismo , Guanilil Ciclase Solúvel/metabolismo , Animais , Feminino , Retardo do Crescimento Fetal/metabolismo , Hipertensão/metabolismo , Gravidez , Ratos , Ratos Endogâmicos Dahl
2.
Kurume Med J ; 50(3-4): 173-5, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14768484

RESUMO

Uterine intravenous leiomyomatosis a rather rare pathologic condition, and a total of 139 cases have appeared in the English literature. Although two proposals for the histologic origin, uterine lyomyoma itself and/or vascular smooth muscle, have been widely accepted, the precise histogenesis still remains unclear. The additional 140th case of intravenous leiomyomatosis is described, and a third postulation for the histogenesis is proposed.


Assuntos
Endometriose/patologia , Leiomiomatose/patologia , Neoplasias Uterinas/patologia , Adulto , Endometriose/etiologia , Feminino , Humanos , Leiomioma/etiologia , Leiomioma/patologia , Leiomiomatose/irrigação sanguínea , Leiomiomatose/etiologia , Neoplasias Uterinas/irrigação sanguínea , Neoplasias Uterinas/etiologia , Útero/irrigação sanguínea
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