Faecal haemoglobin concentration and colorectal cancer site, stage and grade in a symptomatic cohort.

AIM: Minimal evidence exists regarding faecal immunochemical tests (FITs) for colorectal cancer (CRC) site, stage and grade in symptomatic patients. The primary aim is to determine any association between faecal haemoglobin concentration (f-Hb) (analysed with OC-Sensor™ Pledia) and these prognostic factors. The secondary aim is to determine the association between f-Hb and anaemia, microcytosis and iron deficiency (Hb, mean corpuscular volume [MCV] and ferritin). METHODOLOGY: Symptomatic 2-week wait CRC patients with FIT were included (July 2019-October 2022). Median f-Hb and interquartile range according to sex, stage, grade and site (right-sided, caecum to transverse colon, R-CRC; left-sided, splenic flexure to rectum, L-CRC) were compared using the Mann-Whitney U test. Hb, MCV and ferritin were categorized into two groups and the median f-Hb was compared using the Mann-Whitney U test. RESULTS: In all, 114 patients (57 women, 57 men) were studied; 46 had R-CRC (f-Hb = 113 µg Hb/g) and 68 had L-CRC (f-Hb = 342 µg Hb/g) (P = 0.07). Sixty-nine were moderately differentiated CRC (f-Hb = 183 µg Hb/g) and 29 were poorly differentiated (f-Hb = 866 µg Hb/g) (P = 0.04). By T-stage, 35 were early (T1/2) (f-Hb = 170 µg Hb/g) and 79 were advanced (T3/4) (f-Hb = 200 µg Hb/g) (P = 0.06). The relationship between f-Hb and Hb, MCV and ferritin was not significant. Poorly differentiated (P = 0.04) and later stage (P = 0.02) R-CRC had significantly lower f-Hb compared to L-CRC. CONCLUSIONS: Right-sided CRC is associated with lower f-Hb than left. Poorly differentiated and later staged L-CRC had higher median f-Hb. These data add to existing evidence suggesting that FIT may be less sensitive for right-sided CRC. Strategies to mitigate the potential for missed or FIT-negative right-sided CRC are required.

Notochord segmentation in zebrafish controlled by iterative mechanical signaling.

In bony fishes, patterning of the vertebral column, or spine, is guided by a metameric blueprint established in the notochord sheath. Notochord segmentation begins days after somitogenesis concludes and can occur in its absence. However, somite patterning defects lead to imprecise notochord segmentation, suggesting that these processes are linked. Here, we identify that interactions between the notochord and the axial musculature ensure precise spatiotemporal segmentation of the zebrafish spine. We demonstrate that myoseptum-notochord linkages drive notochord segment initiation by locally deforming the notochord extracellular matrix and recruiting focal adhesion machinery at these contact points. Irregular somite patterning alters this mechanical signaling, causing non-sequential and dysmorphic notochord segmentation, leading to altered spine development. Using a model that captures myoseptum-notochord interactions, we find that a fixed spatial interval is critical for driving sequential segment initiation. Thus, mechanical coupling of axial tissues facilitates spatiotemporal spine patterning.

Association of COVID 19 pneumonitis and acute mesenteric ischemia.

Key Clinical Message: D. dimer could be useful as an indicator in diagnosis of mesenteric ischemia in COVID patients. A two staged damage control emergency laparotomy is of good benefits in such patients. Abstract: Bowel ischemia in COVID 19 patients is extremely rare condition results from migrating thrombus formed by a hypercoagulable inflammatory state that is frequently associated COVID 19 infection. A two staged damage control emergency laparotomy is of good benefits in general especially in those with active COVID 19 infection.

A Model of Stakeholder Engagement with American Indians and Alaska Natives from the Native-CHART Study.

American Indian (AI) and Alaska Native (AN) community stakeholder engagement has the power to transform health research. However, the engagement and dissemination process is challenging in AIAN communities due to the historical and current negative experiences of AIAN populations in health research (Dillard et al., 2018). Whereas there is a paucity of recommendations about how to engage stakeholders in health research, from agenda-setting to proposal development, study design, recruitment, data collection, analysis, results, and dissemination (Concannon et al., 2014), there is limited information about how these recommendations are operationalized within the context of AIAN health research and practice (Concannon et al., 2014; Forsythe et al., 2016). For the purposes of this article, stakeholders are individuals, organizations, or communities who have a direct interest in the process and outcomes of a project, research, or policy effort (Boaz et al., 2018). Stakeholder engagement is a systematic process involving stakeholders, which provides opportunities for consultation, input, reviews, reactions, support, and assistance with dissemination. Dissemination focuses on how, when, by whom, and under what circumstances evidence spreads throughout agencies, organizations, states, counties, communities, tribes, researchers, policy makers, and service organizations.

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer.

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBC that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating TNBC. METHODS: We sought to identify novel therapeutic targets in TNBC by combining genomic and functional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid profile to critical cancer cell properties. Our studies were performed in a large panel of human breast cancer cell lines and patient samples. RESULTS: Comprehensive lipid profiling revealed that phospholipid metabolism is reprogrammed in TNBC cells. We discovered that patatin-like phospholipase domain-containing lipase 8 (PNPLA8) is overexpressed in TNBC cell lines and tissues from breast cancer patients. Silencing of PNPLA8 disrupted phospholipid metabolic reprogramming in TNBC, particularly affecting the levels of phosphatidylglycerol (PG), phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and glycerophosphocholine (GPC). We showed that PNPLA8 is essential in regulating cell viability, migration and antioxidation in TNBC cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3ß and MAPK signaling. CONCLUSIONS: Our study highlights PNPLA8 as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC, which could be further developed as a novel molecular treatment target.

PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.

Dysregulation of the PI3K/AKT pathway is a common occurrence in high-grade serous ovarian carcinoma (HGSOC), with the loss of the tumour suppressor PTEN in HGSOC being associated with poor prognosis. The cellular mechanisms of how PTEN loss contributes to HGSOC are largely unknown. We here utilise time-lapse imaging of HGSOC spheroids coupled to a machine learning approach to classify the phenotype of PTEN loss. PTEN deficiency induces PI(3,4,5)P3 -rich and -dependent membrane protrusions into the extracellular matrix (ECM), resulting in a collective invasion phenotype. We identify the small GTPase ARF6 as a crucial vulnerability of HGSOC cells upon PTEN loss. Through a functional proteomic CRISPR screen of ARF6 interactors, we identify the ARF GTPase-activating protein (GAP) AGAP1 and the ECM receptor ß1-integrin (ITGB1) as key ARF6 interactors in HGSOC regulating PTEN loss-associated invasion. ARF6 functions to promote invasion by controlling the recycling of internalised, active ß1-integrin to maintain invasive activity into the ECM. The expression of the CYTH2-ARF6-AGAP1 complex in HGSOC patients is inversely associated with outcome, allowing the identification of patient groups with improved versus poor outcome. ARF6 may represent a therapeutic vulnerability in PTEN-depleted HGSOC.

Dynamic BMP signaling mediates notochord segmentation in zebrafish.

The vertebrate spine is a metameric structure composed of alternating vertebral bodies (centra) and intervertebral discs.1 Recent studies in zebrafish have shown that the epithelial sheath surrounding the notochord differentiates into alternating cartilage-like (col2a1/col9a2+) and mineralizing (entpd5a+) segments which serve as a blueprint for centra formation.2,3,4,5 This process also defines the trajectories of migrating sclerotomal cells that form the mature vertebral bodies.4 Previous work demonstrated that notochord segmentation is typically sequential and involves the segmented activation of Notch signaling.2 However, it is unclear how Notch is activated in an alternating and sequential fashion. Furthermore, the molecular components that define segment size, regulate segment growth, and produce sharp segment boundaries have not been identified. In this study, we uncover that a BMP signaling wave acts upstream of Notch during zebrafish notochord segmentation. Using genetically encoded reporters of BMP activity and signaling pathway components, we show that BMP signaling is dynamic as axial patterning progresses, leading to the sequential formation of mineralizing domains in the notochord sheath. Genetic manipulations reveal that type I BMP receptor activation is sufficient to ectopically trigger Notch signaling. Moreover, loss of Bmpr1ba and Bmpr1aa or Bmp3 function disrupts ordered segment formation and growth, which is recapitulated by notochord-specific overexpression of the BMP antagonist, Noggin3. Our data suggest that BMP signaling in the notochord sheath precedes Notch activation and instructs segment growth, facilitating proper spine morphogenesis.

Nonconsensual Dissemination of Sexual Images Among Adolescents: Associations With Depression and Self-Esteem.

The nonconsensual dissemination of sexual images is a form of image-based sexual abuse that is relatively common among adolescents. However, literature on this issue with adolescent samples is relatively scarce. Therefore, this study is aimed at investigating how this phenomenon varies based on gender and sexual orientation, along with its association with depression and self-esteem. Participants were 728 secondary school students in Sweden (50.4% girls and 46.4% boys; 14.4% lesbian, gay, bisexual [LGB+]) aged from 12 to 19 years (M = 14.35, SD = 1.29). A survey was administered during school hours, including a measure assessing the nonconsensual dissemination of sexual images, the short version of the Moods and Feelings Questionnaire, and the Rosenberg's Self-Esteem Scale. Results showed that LGB+ participants were more likely to indicate that they were victimized compared to their heterosexual peers, while no differences were observed for gender. Being the target of nonconsensual dissemination of sexual images was positively associated with depression, whereas no significant associations were yielded for self-esteem. Based on the findings from this study, we suggest raising adolescent awareness in relation to the nonconsensual dissemination of sexual images as a form of sexual abuse that can have detrimental effects on those who are targeted. Such educational programs should be inclusive of sexual minority adolescents, as they are at a particular risk of being the target of nonconsensual dissemination of sexual images. Psychological support should be provided to the targets of this form of abuse, through both school and online counseling. Future research should adopt longitudinal designs while recruiting diverse samples.

Axial segmentation by iterative mechanical signaling.

In bony fishes, formation of the vertebral column, or spine, is guided by a metameric blueprint established in the epithelial sheath of the notochord. Generation of the notochord template begins days after somitogenesis and even occurs in the absence of somite segmentation. However, patterning defects in the somites lead to imprecise notochord segmentation, suggesting these processes are linked. Here, we reveal that spatial coordination between the notochord and the axial musculature is necessary to ensure segmentation of the zebrafish spine both in time and space. We find that the connective tissues that anchor the axial skeletal musculature, known as the myosepta in zebrafish, transmit spatial patterning cues necessary to initiate notochord segment formation, a critical pre-patterning step in spine morphogenesis. When an irregular pattern of muscle segments and myosepta interact with the notochord sheath, segments form non-sequentially, initiate at atypical locations, and eventually display altered morphology later in development. We determine that locations of myoseptum-notochord connections are hubs for mechanical signal transmission, which are characterized by localized sites of deformation of the extracellular matrix (ECM) layer encasing the notochord. The notochord sheath responds to the external mechanical changes by locally augmenting focal adhesion machinery to define the initiation site for segmentation. Using a coarse-grained mathematical model that captures the spatial patterns of myoseptum-notochord interactions, we find that a fixed-length scale of external cues is critical for driving sequential segment patterning in the notochord. Together, this work identifies a robust segmentation mechanism that hinges upon mechanical coupling of adjacent tissues to control patterning dynamics.

Dublin Anti-Bullying Self-Efficacy Scales: Bifactor and Item Response Theory Models.

Dublin Anti-Bullying Self-Efficacy Scales aim to measure the effectiveness of school anti-bullying programs in promoting five steps that victims and bystanders take against online and offline bullying behaviors. These steps are anti-bullying self-efficacy beliefs to recognize bullying behaviors, comprehend emergency, take responsibility, know what to do, and intervene. However, when an anti-bullying program is very effective for the majority of participants who give high scores, a considerable number of participants who give low scores are very likely to be detected as outliers. This raises two measurement issues. First, high scores create highly negatively skewed data and lead to measuring a unidimensional rather than multidimensional construct. This could be one reason why recent research has been unclear about the extent to which the scales measure a unidimensional, multidimensional, or bifactor construct. Second, should outliers be removed or be considered as participants for whom the program was ineffective? If the scales had measurement invariance across the group of outliers and non-outliers or low and high self-efficacy, it could be concluded that the anti-bullying program was ineffective for some participants. The current research aims to address these issues by testing both measurement invariance as well as unidimensional and bifactor models of anti-bullying self-efficacy. Results of Pure Exploratory Bifactor (PEBI) Analyses and Item Response Theory (IRT) with Two-Parameter-Logistic (2PL) Models of data from a convenience sample of 14-year-old students in Ireland (N = 1,222) indicated sufficient psychometric properties of both unidimensional and multidimensional scales for victim offline, victim online, bystander offline, and bystander online. Further research can use these scales for measuring the bifactor model of anti-bullying self-efficacy as well as the cut-off score for distinguishing between low and high anti-bullying self-efficacy.

The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda.

Hepatitis B virus (HBV) infection represents a significant global health threat, accounting for 300 million chronic infections and up to 1 million deaths each year. HBV disproportionately affects people who are under-served by health systems due to social exclusion, and can further amplify inequities through its impact on physical and mental health, relationship with stigma and discrimination, and economic costs. The 'inclusion health' agenda focuses on excluded and vulnerable populations, who often experience barriers to accessing healthcare, and are under-represented by research, resources, interventions, advocacy, and policy. In this article, we assimilate evidence to establish HBV on the inclusion health agenda, and consider how this view can inform provision of better approaches to diagnosis, treatment, and prevention. We suggest approaches to redress the unmet need for HBV interventions among excluded populations as an imperative to progress the global goal for the elimination of viral hepatitis as a public health threat.

Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.

The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types. How PODXL presents this duality in effect remains unknown. We identify an unexpected function of PODXL as a decoy receptor for galectin-3 (GAL3), whereby the PODXL-GAL3 interaction releases GAL3 repression of integrin-based invasion. Differential cortical targeting of PODXL, regulated by ubiquitination, is the molecular mechanism controlling alternate fates. Both PODXL high and low surface levels occur in parallel subpopulations within cancer cells. Orthotopic intraprostatic xenograft of PODXL-manipulated cells or those with different surface levels of PODXL define that this axis controls metastasis in vivo. Clinically, interplay between PODXL-GAL3 stratifies prostate cancer patients with poor outcome. Our studies define the molecular mechanisms and context in which PODXL promotes invasion and metastasis.

Dublin Anti-Bullying Self-Efficacy Models and Scales: Development and Validation.

Literature on anti-bullying programs shows a growing consensus about promoting victims and bystanders' self-efficacy against bullying, but provides no theoretical model nor measurement scale to assess the extent of achieving this aim. The current research aims to address these theoretical and empirical gaps by proposing the Dublin Anti-Bullying Self-Efficacy Models and Scales, using a convenience sample of 14-year-old students in Ireland (N = 1,100). After establishing both content and face validity, four separate scales were tested to measure anti-bullying self-efficacy beliefs among offline victims (20-item), online victims (20-item), offline bystanders (20-item), and online bystanders (20-item). Thereafter, four separate exploratory factor analyses of the scale items were followed by reflective measurement analyses of their internal consistency and construct (convergent and discriminant) validity. Results indicated sufficient psychometric properties of each scale measuring five dimensions of anti-bullying self-efficacy: recognition, emergency comprehension, responsibility, knowledge, and intervention. Further research is needed to test the proposed model and scale for assessing effectiveness of an anti-bullying program in promoting self-efficacy beliefs.

Rhombencephalitis in Pregnancy-A Challenging Case of Probable Listeria Infection.

Rhombencephalitis refers to inflammation of the brainstem and cerebellum, and can be caused by infections, autoimmune disorders or paraneoplastic syndromes. The most common infective cause is the bacterium Listeria monocytogenes. Listeria monocytogenes is the predominant species to cause human listeriosis, and is commonly due to the ingestion of contaminated foods. Symptoms include a mild gastroenteritis, fever (often with extreme temperature variations), headache, and myalgia. In more severe cases, invasive disease may lead to bacteraemia and neurolisteriosis. Pregnant women are more susceptible to listeriosis, which is believed to be due to pregnancy-related immune modulation. Maternal-neonatal infection with adverse pregnancy outcomes include neonatal listeriosis, spontaneous miscarriage and intrauterine fetal demise. Diagnosis may be challenging due to initial nonspecific symptoms and low sensitivity and specificity of confirmatory diagnostic laboratory tests. Here, we describe a case of rhombencephalitis in pregnancy, attributed to Listeria, and review the clinical features, diagnosis and multidisciplinary management. Lastly, we describe the immunological response to Listeria monocytogenes and show in vitro pro-inflammatory effects of Listeria monocytogenes on peripheral blood mononuclear cells and placental explants.

Human Amnion/Chorion Membrane May Reduce Transient Recurrent Laryngeal Nerve Injury During Thyroid Surgery.

Recurrent laryngeal nerve (RLN) damage is a significant and prevalent complication of thyroid surgery. Based on the beneficial role of a human amnion/chorion membrane (HACM) allograft in wound management and nerve regeneration, we investigated whether placement of a commercially available HACM allograft on dissected RLN could reduce the occurrence and/or duration of RLN injury during thyroidectomy. Among 67 patients undergoing thyroidectomy, 100 at-risk nerves (exposure of at least 3 cm of RLN) received intraoperative placement of HACM; 205 at-risk RLNs without HACM in 134 matched patients served as controls. Patient-reported vocal analysis, physician-assessed vocal analysis, and laryngoscopic assessment of vocal-fold dysfunction were performed before and after surgery. At 24 h after surgery, 17 patients in the control group (12.5%) had documented voice changes; these changes persisted for at least 3 weeks in seven patients (5%). Only one patient (1.5%) in the HACM group had vocal changes at 24 h after surgery, which resolved within 1 week (P < 0.01). Intraoperative placement of the HACM allograft over at-risk RLNs during thyroidectomy may reduce the incidence, severity, and/or duration of intraoperative RLN injury, which could address a significant complication of head and neck surgery. A larger prospectively designed clinical study is warranted to further investigate a possible benefit of the HACM allograft in thyroid surgery and to begin to understand the mechanisms through which a clinical benefit might be mediated.

Parental mediation in pandemic: Predictors and relationship with children's digital skills and time spent online in Ireland.

During the COVID-19 pandemic, an increasing reliance on digital technology to carry out social, entertainment, work and school activities increased, which may have affected the ways in which parents mediated their children's digital technology use. Given the prominent role that digital technology will have in the future, it is important to investigate parent and child characteristics which impacted parental mediation of children's digital technology use. Therefore, the present study aimed at analysing the frequency of parental mediation strategies (i.e. active and restrictive) during lockdown, their determinants, and how the two strategies affected children's digital skills and time spent online. Data were collected from 461 parent and 461 child participants. Results showed that almost half of parents (46%) practiced parental mediation with the same frequency, while the 42.6% applied it more often. Active mediation was predicted by parental worries about online risks, while restrictive mediation was predicted by time spent online by children, parental worries about online risks, parental negative attitudes towards digital technology and parents' digital skills. Children developed more digital skills when their parents applied higher levels of both active and restrictive mediation, and they spent the lowest amount of time online when their parents employed higher levels of restrictive and lower levels of active mediation. Practical implications for families and children's wellbeing are discussed.

Sex Differences in Adolescent Bullying Behaviours / Las diferencias de sexo en las conductas de acoso de los adolescentes

In recent decades there has been a progressive increase in concern and research into the problems of peer aggression, both in the educational setting and more recently, online. The present study sought to explore sex differences in traditional bullying and cyberbullying, since current literature has not reached a consensus in how bullying involvement could be moderated by sex. The sample consisted of 3,174 adolescents aged 12-17 years old who completed a paper survey which included the European Bullying Intervention Project Questionnaire and the European Cyberbullying Intervention Project Questionnaire. The main results found no differences in cyberbullying rates for boys and girls. In the case of bullying, there were more bully-victims among the boys, but no differences were found in the pure victims or pure perpetrators. When analysing the specific bullying behaviours suffered or perpetrated, several differences were found. However, said differences were discrete and it seems that there are not distinctly differentiated bullying patterns, which discourages the use of clearly differentiated preventive strategies for boys and girls. (AU)

En las últimas décadas ha ido creciendo la preocupación por las agresiones entre iguales y su investigación, tanto en el propio entorno escolar como, más recientemente, a través de la red. El presente estudio se planteó con el objetivo de explorar las diferencias de sexo tanto en el acoso tradicional como en el ciberacoso, pues la bibliografía existente no llega a un consenso sobre la forma en que la implicación en el acoso puede estar siendo moderada por el sexo o el género. La muestra constó de 3,174 adolescentes de 12 a 17 años que cumplimentaron por escrito una encuesta que incluía el European Bullying Intervention Project Questionnaire y el European Cyberbullying Intervention Project Questionnaire. Los principales resultados no mostraron diferencias en las tasas de ciberacoso de chicas y chicos. Respecto al acoso tradicional, aunque se han hallado más víctimas-agresoras en los chicos, no se han encontrado diferencias en la tasa de víctimas y agresores puros. Al analizar las conductas específicas sufridas o perpetradas, se encontraron varias diferencias entre chicas y chicos. Sin embargo, esas diferencias eran pequeñas y no parece que haya un patrón de acoso claramente diferenciado, lo que desaconseja emplear estrategias preventivas claramente diferenciadas para chicas y para chicos. (AU)

Cyberbullies, the Cyberbullied, and Problematic Internet Use: Some Reasonable Similarities.

BACKGROUND: The spread of the internet and Information and Communications Technologies (ICT) have completely changed society in the last few decades. The transfer of traditional face-to-face bullying to the virtual environment is one of the risks adolescents face in this new reality. The present study sought to explore the relationship between involvement in cyberbullying and behaviours such as internet and mobile usage and other risky online behaviours. METHOD: The sample consisted of 3,188 adolescents aged 12-17 years old (Mean= 14.44; SD= 1.67). RESULTS: The application of the European Cyberbullying Intervention Project Questionnaire (ECIPQ) found that 5.2% were victims, 4.5% perpetrators and 4.3% bully-victims. CONCLUSIONS: Results also showed that cyberbullying seems to be associated with both Problematic Internet Use and behaviours such as sexting, gambling and contacting strangers, which suggests a need for a comprehensive approach for preventing all these issues. Moreover, parental monitoring could serve as a modulating factor, which should also be taken into account in the development of appropriate prevention strategies.

Cyberbullies, the Cyberbullied, and Problematic Internet Use: Some Reasonable Similarities / Ciberacosados, Ciberacosadores y Uso Problemático de Internet: Algunos Parecidos Razonables

Background: The spread of the internet and Information and Communications Technologies (ICT) have completely changed society inthe last few decades. The transfer of traditional face-to-face bullying to the virtual environment is one of the risks adolescents face in this new reality. The present study sought to explore the relationship between involvement in cyberbullying and behaviours such as internet and mobile usage and other risky online behaviours. Method: The sample consisted of 3,188 adolescents aged 12-17 years old (Mean= 14.44; SD= 1.67). Results: The application of the European Cyberbullying Intervention Project Questionnaire (ECIPQ) found that 5.2% were victims, 4.5% perpetrators and 4.3% bully-victims. Conclusions: Results also showed that cyberbullying seems to be associated with both Problematic Internet Use and behaviours such as sexting, gambling and contacting strangers, which suggests a need for a comprehensive approach for preventing all these issues. Moreover, parental monitoring could serve as a modulating factor, which should also be taken into account in the development of appropriate prevention strategies. (AU)

Antecedentes: el uso generalizado de Internet y de las Tecnologías de la Información y las Comunicaciones (TIC) ha cambiado completamente la sociedad en las últimas décadas. La transferencia del tradicional acoso escolar al entorno virtual es uno de los riesgos a los que se enfrentan los adolescentes en esta nueva realidad. El presente estudio se planteó como objetivo explorar la relación entre ciberacoso y uso de Internet y teléfono móvil y otras conductas de riesgo en línea. Método: la muestra estuvo compuesta por 3.188 adolescentes de entre 12 y 17 años (Media= 14,44; DT= 1,67). Resultados: tras aplicar el European Cyberbullying Intervention Project Questionnaire (ECIPQ) se encontró que el 5,2% eran víctimas, 4,5% agresores y el 4,3% víctimasagresoras. Conclusiones: el ciberacoso parece estar asociado tanto al uso problemático de Internet como a comportamientos como el sexting, el juego online o el contacto con desconocidos a través de la Red, lo que sugiere la necesidad de un enfoque integral a nivel de prevención. Además, la supervisión parental constituiría un importante elemento modulador, lo cual debe ser tenido en cuenta para la elaboración de estrategias preventivas efi caces. (AU)

Children's Internet Use, Self-Reported Life Satisfaction, and Parental Mediation in Europe: An Analysis of the EU Kids Online Dataset.

The present research examines how children's time spent online is associated with their perceived life satisfaction accounting for their age, gender, socio-economic status (SES), emotional problems, country, and family environmental factors. This article is based on the data of the large scale cross-sectional EU Kids Online survey from 16 European countries with nationally representative samples of children aged 9-17 (N = 11,200, M age = 13.3, SD = 2.36; 50.6% boys, 49.4% girls). The results indicated that the time children spent online appeared to have no considerable negative effect on their self-reported life satisfaction (SRLS). Comparatively, the positive effects of children's SES and family environment accounted for 43% of the overall 50% of the variance in children's SRLS scores. Considering that children's SES alone accounted for 42% of the variance, children's emotional problems, country of residence, and enabling parental mediation accounted for the remaining 3, 4, and 1% of the variance, respectively. In line with previous studies that urge caution when discussing the negative influence of time spent online on children's mental health and overall wellbeing, the current findings suggest that social-ecological characteristics and how children use the Internet, need to be examined further.