Resistance training maintains physical function but does not prevent changes in body composition and biochemical markers after detraining in aging adults.

OBJECTIVE: The objective of the present study was to analyze the effects of 10 weeks of resistance training (RT) and subsequent 4 weeks of detraining on physical function, body composition, and biochemical markers in aging adults. METHODS: The study sample was selected by convenience and consisted of 12 women with a mean age of 58 ± 7 years. Physical function [Latin-American Group of Development for Maturity (GDLAM) general index], body composition, total and fractional cholesterol, triglycerides, and glycemia were assessed before and after RT (10 weeks) and detraining (4 weeks). RESULTS: After 10 weeks of RT, there were improvements in fat-free mass (39.1 ± 4.2 vs. 39.9 ± 4.4 kg; p < 0.05 and d = 0.2), fat mass (39.9 ± 6.3% vs. 38.7 ± 6.4%; p < 0.05 and d = -0.2), conicity index (1.47 ± 0.07 vs. 1.43 ± 0.06; p = 0.001 and d = -0.6), and physical function (GDLAM index [27.2 ± 5.5 vs. 25.0 ± 4.7; p = 0.001 and d = -0.4]). Significant improvements were also found in total cholesterol (271.8 ± 75.7 vs. 217.2 ± 52.2 mg/dL; p < 0.01 and d = -0.8), LDL-cholesterol (196.5 ± 61.6 vs. 159.3 ± 38.5 mg/dL; p < 0.01 and d = -0.7), HDL-cholesterol (53.1 ± 7.3 vs. 64.3 ± 23.7 mg/dL; p < 0.05 and d = 0.7), and triglycerides (165.8 ± 32.6 vs. 139.9 ± 46.6 mg/dL; p = 0.001 and d = -0.6). After the detraining period, all benefits in physical function were successfully maintained. CONCLUSION: RT provided benefits in physical function, body composition, and biochemical markers in aging adults. However, 4-week detraining impaired body composition and biochemical markers in the investigated sample.

Antimicrobial action of ozonated water and photodynamic therapy with sonic activation in root canals infected with Enterococcus faecalis.

Background: New protocols are constantly being tested in the search for complete disinfection of root canals without the undesirable effects of sodium hypochlorite. This study evaluated the antimicrobial effect of ozonated water and photodynamic therapy (PDT) with sonic activation in root canals infected with Enterococcus faecalis. Material and Methods: Seventy single-rooted canals of human teeth were prepared and contaminated with E. faecalis for 21 days. The teeth were divided into six experimental groups (n=10): ozonized water without (O + S-) and with sonic activation (O + S +); PDT without (PDT + S-) and with sonic activation (PDT + S +); PDT + ozonized water without (PDT + O + S-) and with sonic activation (PDT + O + S +); and two control groups, one positive (n = 5) and one negative (n = 5). Microbial collections were performed before and shortly after treatment, counted in the log of colony-forming units and tested for significant difference between these counts, if any (Student's t-test). The ANOVA two-way test was applied to evaluate whether the Treatment factor (Ozone, PDT and Ozone + PDT) and the Sonic factor (With and without sonic activation) had any effect on microbial reduction. Results: In all protocols, there was a significant microbial reduction (p=0.025), whereas in the groups in which sonic activation was used, the microbial reduction was significantly greater (p=0.001). Conclusions: The treatments significantly reduced the number of microorganisms in the root canals. Sonic activation helped to increase the microbial reduction in infected root canals. Key words:Endodontics, ozone, photodynamic therapy, enterococcus faecalis.

A validation study of a smartphone application for heart rate variability assessment in asymptomatic adults.

BACKGROUND: Assessment of heart rate variability (HRV) is an effective non-invasive tool to obtain data on cardiac autonomic modulation and may be assessed by a range of devices, including mobile applications. Objective: This study aimed to validate a smartphone application by comparing the R-R intervals (RRi) obtained by the app with a classic electrocardiogram (ECG)-derived reference condition Methods: Fifteen asymptomatic adults (24.9±3.4 years) underwent an orthostatic challenge during which RRi were simultaneously recorded by a freeware smartphone application and by an ECG recorder. Pearson correlation coefficients (r) and coefficients of determination (r 2) were calculated to determine the degree of association between the two electronic devices. Two-way repeated measures analysis of variance and Bland-Altman analysis were used to calculate the measurement consistency and agreement, respectively, between the two methods. Effect size was also used to estimate the magnitude of the differences. RESULTS: The number of RRi from asymptomatic adults recorded by the ECG and by the free smartphone application was similar at rest in supine position (13,149 vs. 13,157; P = 0.432) and during orthostatic challenge (10,666 vs. 10,664 P = 0.532). RRi in milliseconds from both devices presented a near perfect correlation in the supine position (r = 0.999; Confidence Interval [CI] at 95%: 0.999-0.999; P < 0.0001) and during orthostatic challenge (r = 0.988; 95% CI: 0.988-0.989; P < 0.0001). A negative bias of -0.526 milliseconds (95% limits of agreement [LoA] from -4.319 to 3.266 milliseconds) was observed in supine position between ECG and the smartphone application. On the other hand, a positive bias of 0.077 milliseconds (95% LoA from -10.090 to 10.240 milliseconds) during the orthostatic challenge was observed. CONCLUSIONS: Our results cross-validated a freeware smartphone application with the ECG-derived reference condition for asymptomatic adults at rest in the supine position and during orthostatic challenge.

Effects of Exercise Training on Cardiovascular and Autonomic Parameters in Stroke Survivors: A Systematic Review

Negative changes in cardiovascular and autonomic variables in stroke survivors have encouraged the global scientific community to focus on investigating therapeutic strategies to mitigate stroke damage. The objective of the present study was to describe the effects of exercise training on cardiovascular and autonomic variables in stroke survivors. We used the PICO (population, intervention, control/comparison, and outcome variables) model for the search of articles in PubMed and Physiotherapy Evidence Databases from 2009 to December 2018. The following data were also recorded: type of study, author, year of publication, participants (time after stroke, sample size, and age) and benefits of exercise training. A total of 544 articles were initially selected, of which nine peer-reviewed articles met the search criteria. These nine studies enrolled 611 participants (middle-aged or elderly), and pointed to positive effects of training on maximal oxygen uptake, peak aerobic capacity, 6-minute walk test and resting heart rate. However, more well-controlled studies are needed to confirm the benefits of exercise training on cardiovascular and autonomic variables in this population

Novel Combined Training Approach Improves Sleep Quality but Does Not Change Body Composition in Healthy Elderly Women: A Preliminary Study.

The aim of this study was to investigate the effects of a novel combined training protocol on sleep quality and body composition of healthy elderly women. The study sample consisted of 8 sedentary elderly individuals with mean (±SD) of 67 (±8) years of age, 96.0 (±7.8) mg/dL fasting blood glucose, 94.4 (±36.1) mg/dL triglycerides, 179.1 (±22.4) mg/dL total cholesterol, 57.2 (±15.7) mg/dL high-density lipoprotein (HDL), 103.1 (±25.2) mg/dL low-density lipoprotein (LDL), 125.3 (±8.4) mmHg systolic blood pressure, and 72.6 (±10.1) mmHg diastolic blood pressure. The training protocol consisted of resistance training exercises (approximately 18-minute duration) combined with aerobic exercises (approximately 26-minute duration), performed interspersed in the same session, for 8 weeks (3 times a week), with a 24-hour interval rest between each session. Continuous variables were expressed as the mean (±standard deviation) and the paired sample t-test compares baseline with final measurement. The results showed a significant improvement (p = 0.01) in quality of sleep (4.9 ± 1.5 versus 3.8 ± 1.8 for total PSQI index) without body significant improvements in the fat-free mass (59.9 ± 4.0 versus 60.5 ± 4.4; p = 0.20) and fat mass (40.1 ± 4.0 versus 39.5 ± 4.4; p = 0.20) in healthy elderly women. In this sense, the novel combined training proposed may be an effective alternative or adjunct to present therapies aimed at improving the sleep quality in this population.

Efeito antimicrobiano in vitro de diferentes medicações endodônticas e própolis sobre Enterococcus faecalis / In vitro antimicrobial effect of different endodontic materials and propolis on Enterococus faecalis

Objetivos: Comparar a eficácia de três irrigantes utilizados no tratamento de canais radiculares e do extrato de própolis frente à Enterococcusfaecalis. Métodos: Foram utilizadas em teste de difusão em Agar as seguintes substâncias: extrato de própolis produzido pelas abelhas Scaptotrigona sp., hipoclorito de sódio 5%, hidróxido de cálcio e gel de clorexidina 2%. O diâmetro da zona de inibição bacteriana foi medidodepois de 24 horas e os dados foram analisados estatisticamente através do teste Kruskal Wallis. A amostra de extrato de própolis tambémfoi submetida ao teste de diluição para determinar a concentração inibitória mínima. Resultados: Os valores, em milímetros, das médias dos halos de inibição produzidos por difusão das amostras testadas foram: 21,3 (gelde clorexidina); 16,2 (hidróxido de cálcio); 10,9 (extrato de própolis); 7,2 (hipoclorito de sódio). Houve diferença estatística significante entre todas as substâncias testadas (p<0,001). O extrato de própolis apresentou a concentração inibitória mínima de 1mg/mL. Conclusão: O extrato de própolis apresentou uma boa atividade antimicrobiana, sendo maior que hipoclorito de sódio a 5%, entretanto, o gel de clorexidina foi o mais efetivo contra E. faecalis.

Objetivos: To compare the efficacy of three irrigants used in root canal treatment and of propolis extract against Enterococcus faecalis. Methods: The Agar diffusion test was used on the following substances: extract of propolis produced by Scaptotrigona sp., bees; 5% sodium hypochlorite, calcium hydroxide and 2% chlorhexidine gel. The diameter of the bacterial zone of inhibition was measured after 24 hours and the data were statistically analyzed by the Kruskal Wallis test. The propolis extract sample was also submitted to the dilution test to determine the minimum inhibitory concentration. Results: The values, in millimeters, of the inhibition haloes produced by diffusion of the tested samples were as follows: 21.3 (chlorhexidine gel); 16.2 (calcium hydroxide); 10.9 (propolis extract); 7.2 (sodium hypochlorite). There was statistically significant difference among all the substances tested. (p<0.001). Propolis extract presented a minimum inhibitory concentration of 1mg/mL. Conclusion: Propolis extract presented good antimicrobial activity, being more active than 5% sodium hypochlorite, however, the chlorhexidine was the most effective agent.