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Trans R Soc Trop Med Hyg ; 116(8): 745-749, 2022 08 05.
Artigo em Inglês | MEDLINE | ID: mdl-35394038

RESUMO

Loa loa microfilariae were found on thick blood smears (TBSs) from 8 of 300 (2.7%) residents of Bioko Island, Equatorial Guinea, during a Plasmodium falciparum sporozoite malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites were not discovered in the other seven until subsequent TBSs were performed, at times many weeks into the study. All infected individuals were asymptomatic, and were offered treatment with diethylcarbamazine, per national guidelines. L. loa microfilaraemia complicated the enrolment or continued participation of these eight trial subjects, and only one was able to complete all study procedures. If ruling out loiasis is deemed to be important during clinical trials, tests that are more sensitive than TBSs should be performed.


Assuntos
Vacinas Antimaláricas , Malária Falciparum , Animais , Guiné Equatorial , Humanos , Loa , Vacinas Antimaláricas/uso terapêutico , Malária Falciparum/prevenção & controle , Sujeitos da Pesquisa , Esporozoítos
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