Cognitive reserve and brain maintenance in aging and dementia: An integrative review.

This research is an integrative review of scientific evidence differentiating between cognitive reserve (CR) and brain maintenance concepts. Thus, we have examined how CR socio-behavioral proxies (i.e. education, occupational attainment, and leisure activities) may help to cope with age-related cognitive decline and negative consequences of brain pathology. We also analyze lifestyle factors associated with brain maintenance or the relative absence of change in neural resources over time. Medline and Web of Science databases were used for the bibliographic search in the last 20 years. Observational cohort studies were selected to analyze the effect of different CR proxies on cognitive decline, including dementia incidence, whereas studies employing functional neuroimaging (fMRI) were used to display the existence of compensation mechanisms. Besides, structural MRI studies were used to test the association between lifestyle factors and neural changes. Our findings suggest that education, leisure activities, and occupational activity are protective factors against cognitive decline and dementia. Moreover, functional neuroimaging studies have verified the existence of brain networks that may underlie CR. Therefore, CR may be expressed either through a more efficient utilization (neural reserve) of brain networks or the recruitment of additional brain regions (compensation). Finally, lifestyle factors such as abstaining from smoking, lower alcohol consumption, and physical activity contributed to brain maintenance and were associated with the preservation of cognitive function. Advances in multimodal neuroimaging studies, preferably longitudinal design, will allow a better understanding of the neural mechanisms associated with the prevention of cognitive decline and preservation of neural resources in aging.

Cultural Adaptation of Cognitive Stimulation Therapy (CST) for Portuguese People with Dementia.

OBJECTIVES: Portugal is one of the most aged countries in the world and dementia is increasing among the Portuguese population. It is estimated to affect around 200,000 people in Portugal. There is a clear need for non-pharmacological interventions to ameliorate the symptoms of dementia and improve the quality of life. Cognitive Stimulation Therapy (CST), a worldwide well-known program developed in the United Kingdom (UK), is recognized as a cost-effective intervention, with benefits both in cognitive function and quality of life of people with mild to moderate dementia. We tested the feasibility and cultural appropriateness and adapted CST to Portuguese people with dementia. METHODS: The Formative Method for Adapting Psychotherapy (FMAP) model for cultural adaptation was used. A focus group discussion with health professionals and caregivers provided the basis for cultural adaptation, as well as feedback from participants, caregivers, and facilitators after a pilot study. RESULTS: Some modifications were required, especially related to linguistic issues, in 11 of the 14 CST sessions. The adapted program was found to be acceptable and enjoyable in a small sample of people with dementia in a rehabilitation context. CONCLUSIONS: CST seems feasible and culturally appropriate in Portugal. A systematically developed and culturally adapted manual is ready to be used in a large-scale implementation and validation of CST in Portugal. CLINICAL IMPLICATIONS: CST is a valid program for the Portuguese culture, contributes to the availability of a structured and effective clinical intervention for PwD in Portugal and to the possibility of comparing programs across countries.

The influence of cognitive reserve in the protection of the cognitive status after an acquired brain injury: A systematic review.

BACKGROUND: Cognitive Reserve (CR) hypothesis was introduced to account for the variability in cognitive performance of patients with similar degrees of brain injury or pathology. The individual variability of CR is modulated by the interaction of innate capacities and exposures throughout life, which can act as protectors against neuropathology's clinical effects. Individuals with higher CR appear to have better cognitive performance after a brain injury. The present review aimed to identify and map the scientific evidence available in literature regarding CR's influence in protecting the cognitive status after an Acquired Brain Injury (ABI). METHOD: A systematic review was performed for published studies until October 2020 in PubMed, Scopus, and CINAHL electronic databases. Studies regarding CR's influence in protecting the cognitive status after an ABI were included in this review. The Newcastle-Ottawa Scale was used to assess risk of bias in the included studies. This systematic review was recorded in the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42021236594. RESULTS: Twenty-one studies published between 2003 and 2020 were selected and analyzed. The literature analysis showed that CR has a positive effect on cognitive status after an ABI. Various proxies were used to estimate CR, including estimated premorbid IQ, education, occupation attainment, socioeconomic status, leisure activities, bilingualism, and social integration. CR proxies constitute a set of variables that may have a significant influence on cognitive status. Higher CR levels were associated with lower cognitive impairment after an ABI. CONCLUSIONS: Although more research is necessary for a complete understanding of CR's impact on cognition, the synthesis of these studies confirmed that there is evidence on the beneficial impact of CR on cognitive status after an ABI. These findings support CR's cognitive status role following an ABI and may provide additional information for prognosis and rehabilitation plans.

An exploration of prospective memory components and subtasks of the Memory for Intentions Test (MIST).

Introduction: Prospective Memory (PM), the ability to execute future intentions, decreases with age and memory-related disorders and may be an early predictor of dementia. The Memory for Intentions Test (MIST) allows the assessment of multiple aspects of PM using a range of subtasks. The current study evaluated and explored a Portuguese version of the MIST and its subtasks.Method: Forty-one patients with Mild Cognitive Impairment (MCI) and forty healthy participants performed the MIST, neuropsychological tests and questionnaires. Analyses were performed testing relationships between MCI and PM components of the MIST, and differences between subtasks of the test were explored.Results: Reliability of the PM component was acceptable within the patient group, but not within the control group. PM components were significantly lower in the MCI patients, but this effect was dependent on subtasks. Groups differed most strongly at shorter intervals. PM scores predicted MCI status. Correlations were found between PM components and cognitive functioning scales.Conclusions: The Portuguese version of the MIST seems suitable for use in clinical practice and research. MCI is differentially related to different PM components and subtasks of the MIST.

Unisensory and multisensory Self-referential stimulation of the lower limb: An exploratory fMRI study on healthy subjects.

BACKGROUND: The holistic view of the person is the essence of the physiotherapy. Knowledge of approaches that develop the whole person promotes better patient outcomes. Multisensory Self-referential stimulation, more than a unisensory one, seems to produce a holistic experience of the Self ("Core-Self"). OBJECTIVES: (1) To analyze the somatotopic brain activation during unisensory and multisensorial Self-referential stimulus; and (2) to understand if the areas activated by multisensorial Self-referential stimulation are the ones responsible for the "Core-Self." METHODS: An exploratory functional magnetic resonance imaging (fMRI) study was performed with 10 healthy subjects, under the stimulation of the lower limbs with three Self-referential stimuli: unisensory auditory-verbal, unisensory tactile-manual, and multisensory, applying the unisensory stimuli simultaneously. RESULTS: Unisensory stimulation elicits bilateral activations of the temporoparietal junction (TPJ), of the primary somatosensory cortex (S1), of the primary motor cortex (BA4), of the premotor cortex (BA6) and of BA44; multisensory stimulation also elicits activity in TPJ, BA4, and BA6, and when compared with unisensory stimuli, activations were found in: (1) Cortical and subcortical midline structures-BA7 (precuneus), BA9 (medial prefrontal cortex), BA30 (posterior cingulated), superior colliculum and posterior cerebellum; and (2) Posterior lateral cortex-TPJ, posterior BA13 (insula), BA19, and BA37. Bilateral TPJ is the one that showed the biggest activation volume. CONCLUSION: This specific multisensory stimulation produces a brain activation map in regions that are responsible for multisensory Self-processing and may represent the Core-Self. We recommend the use of this specific multisensory stimulation as a physiotherapy intervention strategy that might promote the Self-reorganization.

Disentangling Linguistic Modality Effects in Semantic Processing.

Sensory systems are essential for perceiving and conceptualizing our semantic knowledge about the world and the way we interact with it. Despite studies reporting neural changes to compensate for the absence of a given sensory modality, studies focusing on the assessment of semantic processing reveal poor performances by deaf individuals when compared with hearing individuals. However, the majority of those studies were not performed in the linguistic modality considered the most adequate to their sensory capabilities (i.e., sign language). Therefore, this exploratory study was developed focusing on linguistic modality effects during semantic retrieval in deaf individuals in comparison with their hearing peers through a category fluency task. Results show a difference in performance between the two linguistic modalities by deaf individuals as well as in the type of linguistic clusters most chosen by participants, suggesting a complex clustering tendency by deaf individuals.

Reliability and Validity of the European Portuguese Version of the Social Touch Questionnaire.

Social touch is essential for physical and emotional well-being. However, different meanings can be attributed to physical contact during social interactions and may generate bonding or avoidant behaviors. This personal and unique experience is not usually taken into account in health and social care services. The aim of this study is to produce a valid and reliable European Portuguese version of the Social Touch Questionnaire (STQ, Wilhelm et al. in Biol Psychol 58:181-202, 2001. doi:10.1016/S0301-0511(01)00113-2). The STQ is a self-report questionnaire for adolescents and adults measuring behaviors and attitudes towards social touch. The original version was translated into European Portuguese using a forward-back translation process and its feasibility was examined. To evaluate the psychometric properties, a total of 242 Portuguese university students participated in the study (21.3 ± 3.8 years). The STQ was considered feasible, showed adequate internal consistency (Cronbach's α = .734), and the test-retest correlation with the STQ items demonstrated a high concordance between the tests over a two-week interval (ICC = .990; n = 50). Validity tests were performed, comparing the total score of the STQ with that of the anxiety and avoidance subscales of the Social Interaction and Performance Anxiety and Avoidance Scale (SIPAAS). A very significant conceptual convergence was confirmed between the STQ and with the SIPAAS-Anxiety (r = .64; p < .0001) and with the SIPAAS-Avoidance (r = .59; p < .0001). The exploratory factor analysis, with Promax rotation, revealed 3 factors: dislike of physical touch, liking of familiar physical touch and liking of public physical touch (Cronbach's alphas ranged from .68 to .75). Psychometric properties confirmed the adaptation of the STQ to the Portuguese culture. It is a reliable and valid self-report questionnaire and it appears to be a useful tool to assess behaviors and attitudes towards social touch.

Cognitive output of a neuropsychological stimulation program in an elderly day care center with low educated participants: an observational study / Desfecho cognitivo de um programa de estimulação neuropsicológica em um centro dia para idosos com participantes de baixa escolaridade: um estudo observacional

OBJECTIVE: In the present paper we present an observational study of the implementation of a Neuropsychological Stimulation Program at an Elderly Day Care Center in low-educated participants with very similar backgrounds concerning social economic status. METHODS: The implemented program tackled several dimensions, including daily orientation sessions, cognitive stimulation sessions twice a week, followed by movement sessions, and structured sessions conducted every two weeks. Cognitive Evaluation was performed before and after implementation of the program. RESULTS: Results are discussed taking into consideration cognitive outputs as well as non-cognitive outputs and the specificities of community-based intervention. CONCLUSION: It was concluded that community-based intervention is set to become vital in promoting dementia prevention.

OBJETIVO: No presente artigo, apresentamos um estudo observacional sobre a implementação de um Programa de Estimulação Neuropsicológica em um Centro Dia para idosos, envolvendo idosos de baixa escolaridade com perfil socioeconômico homogêneo. MÉTODOS: O programa implementado abordou várias dimensões, incluindo sessões diárias de orientação, sessões de estimulação cognitiva duas vezes por semana, seguidas de sessões de atividade motora, e sessões estruturadas que foram conduzidas a cada duas semanas. A avaliação cognitiva foi conduzida antes e depois da implementação do programa. RESULTADOS: Os resultados são discutidos levando em consideração desfechos cognitivos e não-cognitivos e as especificidades da intervenção de base comunitária. CONCLUSÃO: Concluiu-se que a intervenção com base na comunidade será vital para a prevenção das demências.

Cognitive output of a neuropsychological stimulation program in an elderly day care center with low educated participants: An observational study.

OBJECTIVE: In the present paper we present an observational study of the implementation of a Neuropsychological Stimulation Program at an Elderly Day Care Center in low-educated participants with very similar backgrounds concerning social economic status. METHODS: The implemented program tackled several dimensions, including daily orientation sessions, cognitive stimulation sessions twice a week, followed by movement sessions, and structured sessions conducted every two weeks. Cognitive Evaluation was performed before and after implementation of the program. RESULTS: Results are discussed taking into consideration cognitive outputs as well as non-cognitive outputs and the specificities of community-based intervention. CONCLUSION: It was concluded that community-based intervention is set to become vital in promoting dementia prevention.

OBJETIVO: No presente artigo, apresentamos um estudo observacional sobre a implementação de um Programa de Estimulação Neuropsicológica em um Centro Dia para idosos, envolvendo idosos de baixa escolaridade com perfil socioeconômico homogêneo. MÉTODOS: O programa implementado abordou várias dimensões, incluindo sessões diárias de orientação, sessões de estimulação cognitiva duas vezes por semana, seguidas de sessões de atividade motora, e sessões estruturadas que foram conduzidas a cada duas semanas. A avaliação cognitiva foi conduzida antes e depois da implementação do programa. RESULTADOS: Os resultados são discutidos levando em consideração desfechos cognitivos e não-cognitivos e as especificidades da intervenção de base comunitária. CONCLUSÃO: Concluiu-se que a intervenção com base na comunidade será vital para a prevenção das demências.

The ex-illiterate brain: the critical period, cognitive reserve and HAROLD model / O cérebro ex-analfabeto: o período crítico, reserva cognitiva e o modelo HAROLD

Abstract ? The lifelong acquisition of cognitive skills shapes the biology of the brain. However, there are critical periods for the best use of the brain to process the acquired information. Objectives: To discuss the critical period of cognitive acquisition, the concept of cognitive reserve and the HAROLD (Hemispheric Asymmetry Reduction in Older adults) model. Methods: Seven women who learned how to read and to write after the age of 50 (ex-illiterates) and five women with 10 years of regular schooling (controls) were submitted to a language recognition test while brain activity was being recorded using magnetoencephalography. Spoken words were delivered binaurally via two plastic tubs terminating in ear inserts, and recordings were made with a whole head magnetometer consisting of 148 magnetometer coils. Results: Both groups performed similarly on the task of identifying target words. Analysis of the number of sources of activity in the left and right hemispheres revealed significant differences between the two groups, showing that ex-illiterate subjects exhibited less brain functional asymmetry during the language task. Conclusions: These results should be interpreted with caution because the groups were small. However, these findings reinforce the concept that poorly educated subjects tend to use the brain for information processing in a different way to subjects with a high educational level or who were schooled at the regular time. Finally, the recruiting of both hemispheres to tackle the language recognition test occurred to a greater degree in the ex-illiterate group where this can be interpreted as a sign of difficulty performing the task.

Resumo ? A aquisição ao longo da vida de competências cognitivas moldam a biologia do cérebro. No entanto, existem períodos críticos para o cérebro processar melhor as informações adquiridas. Objetivos: Discutir o período crítico de aquisição cognitiva, o conceito de reserva cognitiva e o modelo HAROLD (Redução da Assimetria Hemisférica em Idosos). Métodos: Sete mulheres que aprenderam a ler e escrever após a idade de 50 anos (ex-analfabetos) e cinco mulheres com 10 anos de escolaridade regular (controles) foram submetidas a um teste de reconhecimento de palavras enquanto a atividade cerebral estava sendo registrada mediante magnetoencefalografia. As palavras foram ouvidas com o emprego de dois tubos plásticos conectados a cada orelha e as gravações foram feitas com um magnetômetro de cabeça inteira com 148 bobinas de registro. Resultados: Ambos os grupos tiveram desempenho semelhante na identificação das palavras-alvo. Análise do número de fontes de atividade no hemisfério esquerdo e no hemisfério direito revelou diferenças significativas entre os dois grupos, mostrando que os ex-analfabetos tiveram menor assimetria cerebral funcional no desempenho da tarefa. Conclusões: Estes resultados devem ser interpretados com cautela, pois os grupos são pequenos. No entanto, reforçam o conceito que os indivíduos com baixa escolaridade tendem a usar o cérebro para processar informações de uma forma diferente do que indivíduos com nível educacional elevado ou que tenham o adquirido na época regular. Finalmente, o recrutamento de ambos os hemisférios para reconhecer as palavras ocorreu mais intensamente no grupo de ex-analfabetos e pode ser interpretado como um sinal de maior dificuldade na tarefa.

The ex-illiterate brain: The critical period, cognitive reserve and HAROLD model.

The lifelong acquisition of cognitive skills shapes the biology of the brain. However, there are critical periods for the best use of the brain to process the acquired information. OBJECTIVES: To discuss the critical period of cognitive acquisition, the concept of cognitive reserve and the HAROLD (Hemispheric Asymmetry Reduction in Older adults) model. METHODS: Seven women who learned how to read and to write after the age of 50 (ex-illiterates) and five women with 10 years of regular schooling (controls) were submitted to a language recognition test while brain activity was being recorded using magnetoencephalography. Spoken words were delivered binaurally via two plastic tubs terminating in ear inserts, and recordings were made with a whole head magnetometer consisting of 148 magnetometer coils. RESULTS: Both groups performed similarly on the task of identifying target words. Analysis of the number of sources of activity in the left and right hemispheres revealed significant differences between the two groups, showing that ex-illiterate subjects exhibited less brain functional asymmetry during the language task. CONCLUSIONS: These results should be interpreted with caution because the groups were small. However, these findings reinforce the concept that poorly educated subjects tend to use the brain for information processing in a different way to subjects with a high educational level or who were schooled at the regular time. Finally, the recruiting of both hemispheres to tackle the language recognition test occurred to a greater degree in the ex-illiterate group where this can be interpreted as a sign of difficulty performing the task.

A aquisição ao longo da vida de competências cognitivas moldam a biologia do cérebro. No entanto, existem períodos críticos para o cérebro processar melhor as informações adquiridas. OBJETIVOS: Discutir o período crítico de aquisição cognitiva, o conceito de reserva cognitiva e o modelo HAROLD (Redução da Assimetria Hemisférica em Idosos). MÉTODOS: Sete mulheres que aprenderam a ler e escrever após a idade de 50 anos (ex-analfabetos) e cinco mulheres com 10 anos de escolaridade regular (controles) foram submetidas a um teste de reconhecimento de palavras enquanto a atividade cerebral estava sendo registrada mediante magnetoencefalografia. As palavras foram ouvidas com o emprego de dois tubos plásticos conectados a cada orelha e as gravações foram feitas com um magnetômetro de cabeça inteira com 148 bobinas de registro. RESULTADOS: Ambos os grupos tiveram desempenho semelhante na identificação das palavras-alvo. Análise do número de fontes de atividade no hemisfério esquerdo e no hemisfério direito revelou diferenças significativas entre os dois grupos, mostrando que os ex-analfabetos tiveram menor assimetria cerebral funcional no desempenho da tarefa. CONCLUSÕES: Estes resultados devem ser interpretados com cautela, pois os grupos são pequenos. No entanto, reforçam o conceito que os indivíduos com baixa escolaridade tendem a usar o cérebro para processar informações de uma forma diferente do que indivíduos com nível educacional elevado ou que tenham o adquirido na época regular. Finalmente, o recrutamento de ambos os hemisférios para reconhecer as palavras ocorreu mais intensamente no grupo de ex-analfabetos e pode ser interpretado como um sinal de maior dificuldade na tarefa.