Clinical response to nonsurgical periodontal therapy is associated with decreased serum leukocyte count and uric acid levels in kidney transplant recipients.

OBJECTIVE: This study sought to investigate the relationship between clinical response to nonsurgical periodontal therapy (NSPT) and serum changes in leukocyte count, fasting blood glucose, hemoglobin, hematocrit, creatinine, and uric acid in kidney transplant recipients (KTR). METHODOLOGY: A prospective study was performed on 20 KTRs. Periodontal and serum data were collected before and 90 days after NSPT, and delta values (Δ = after NSPT - before) were calculated. Periodontal assessment included periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP). Patients were classified based on the presence of periodontitis and then categorized into stages. RESULTS: Patients showed a reduction in the percentage of sites with PPD≥3mm, PPD≥4 mm and BOP, after NSPT. There was a direct correlation between the deltas of leukocyte count and CAL ≥3 mm (r=0.645, P=0.002) and BOP (r=0.663, P=0.001), and the deltas of uric acid and CAL ≥3 mm (r=0.562, P=0.010). CONCLUSION: A good clinical response to NSPT may affect the reduction of serum levels of leukocyte count and uric acid, suggesting a beneficial effect on systemic health in KTR.

Clinical response to nonsurgical periodontal therapy is associated with decreased serum leukocyte count and uric acid levels in kidney transplant recipients

Abstract Objective: This study sought to investigate the relationship between clinical response to nonsurgical periodontal therapy (NSPT) and serum changes in leukocyte count, fasting blood glucose, hemoglobin, hematocrit, creatinine, and uric acid in kidney transplant recipients (KTR). Methodology: A prospective study was performed on 20 KTRs. Periodontal and serum data were collected before and 90 days after NSPT, and delta values (Δ = after NSPT - before) were calculated. Periodontal assessment included periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP). Patients were classified based on the presence of periodontitis and then categorized into stages. Results: Patients showed a reduction in the percentage of sites with PPD≥3mm, PPD≥4 mm and BOP, after NSPT. There was a direct correlation between the deltas of leukocyte count and CAL ≥3 mm (r=0.645, P=0.002) and BOP (r=0.663, P=0.001), and the deltas of uric acid and CAL ≥3 mm (r=0.562, P=0.010). Conclusion: A good clinical response to NSPT may affect the reduction of serum levels of leukocyte count and uric acid, suggesting a beneficial effect on systemic health in KTR.

A Cross-Sectional Study of the Association Between Chronic Oral Disease Burden and Serum Biomarkers in Kidney Transplant Recipients.

INTRODUCTION: Poor oral health can negatively affect general health and quality of life of kidney transplant recipients. The study aimed to investigate the association between chronic oral disease burden, serum biomarkers, and comorbidities in kidney transplant recipients. DESIGN: A cross-sectional comparative study was conducted with 44 patients after kidney transplant. The burden of chronic oral disease was composed of the following observable variables: moderate periodontitis and presence of dental caries. Serum biomarkers and comorbidities data were collected. The chi-square or Fisher's exact tests for categorical variables and Student's t-test or Mann-Whitney test for continuous variables were used. Robust Poisson regression was used to model the association. RESULTS: Higher levels of mean uric acid (P = .01) and creatinine (P = .03) were observed in the group of patients with oral disease burden, while the highest level of high-density lipoprotein was observed in the group without oral disease. Higher values of uric acid were associated with the occurrence of chronic oral disease burden (Adjusted PR = 1.24, 95% CI: 1.03-1.48, P = .019). There was no statistical difference between the groups with and without oral disease burden in comorbidities present. CONCLUSION: The findings suggest that chronic oral diseases burden can be associated with uric acid and creatinine levels in kidney transplant recipients.

[Epidemiological surveillance of dental fluorosis in a city with a tropical climate with a fluoridated public drinking water supply]. / Vigilância epidemiológica da fluorose dentária em município de clima tropical com água de abastecimento público fluoretada.

The scope of this study was to evaluate the prevalence and severity of dental fluorosis among 11 to 14-year-old schoolchildren in Teresina, Piauí, Brazil, which is a tropical city with a fluoridated public drinking water supply. It involved a cross-sectional observational study on a sample of 571 students in public and private schools. Informed Consent forms were approved for the data collection and the exams were conducted at the schools. Data were recorded on a questionnaire answered by the parents, regarding the socioeconomic and demographic characteristics and oral hygiene habits of the sample. The dental exam was performed qualified dental sugeons. The Thylstrup-Fejerskov (TF) index was used. The prevalence of fluorosis was 77.9%, and only 12.5% of the affected children had TF ≥ grade 3 (with aesthetic damage). The premolars were the teeth most affected by fluorosis. Among the students with the highest severity of fluorosis, 98.6% belonged to the lowest social bracket (> B2), 91.5% were born and had always lived in Teresina, 94.4% consumed water from the fluoridated public supply, 76% used toothpaste for children and 64% of mothers reported that they swallowed toothpaste. The prevalence of fluorosis was high, though the severity was low in individuals exposed to fluoridation since birth.

Vigilância epidemiológica da fluorose dentária em município de clima tropical com água de abastecimento público fluoretada / Epidemiological surveillance of dental fluorosis in a city with a tropical climate with a fluoridated public drinking water supply

Resumo O objetivo deste estudo foi avaliar a prevalência e a severidade de fluorose dentária em escolares de 11 a 14 anos de idade em Teresina (PI) Brasil, município de clima tropical com água de abastecimento público fluoretada. Estudo do tipo observacional transversal no qual foram avaliadas 571 crianças distribuídas nas redes pública e particular de ensino. A coleta de dados foi realizada nas unidades escolares, após recolhimento do Termo de Consentimento Livre e Esclarecido (TCLE) e questionário respondido pelos pais referentes às condições socioeconômicas e demográficas e aos hábitos de higiene bucal. O exame dentário foi realizado por um cirurgião-dentista calibrado. O índice aplicado foi o Thylstrup e Fejerskov (TF). A prevalência de fluorose foi de 77,9%, e apenas 12,5% das crianças acometidas apresentaram TF ≥ 3, grau com comprometimento estético. Os pré-molares foram os dentes mais afetados pela fluorose. Dentre os escolares com maior severidade de fluorose, 98,6% dos pertenciam à classe social mais baixa (>B2), 91,5% nasceram e sempre moraram em Teresina, 94,4% consumiam água de abastecimento fluoretada, 76% usaram dentifrício infantil e 64% as mães relataram que engoliam dentifrício. A prevalência de fluorose foi elevada, mas com baixa severidade, em indivíduos expostos à fluoretação desde o nascimento.

Abstract The scope of this study was to evaluate the prevalence and severity of dental fluorosis among 11 to 14-year-old schoolchildren in Teresina, Piauí, Brazil, which is a tropical city with a fluoridated public drinking water supply. It involved a cross-sectional observational study on a sample of 571 students in public and private schools. Informed Consent forms were approved for the data collection and the exams were conducted at the schools. Data were recorded on a questionnaire answered by the parents, regarding the socioeconomic and demographic characteristics and oral hygiene habits of the sample. The dental exam was performed qualified dental sugeons. The Thylstrup-Fejerskov (TF) index was used. The prevalence of fluorosis was 77.9%, and only 12.5% of the affected children had TF ≥ grade 3 (with aesthetic damage). The premolars were the teeth most affected by fluorosis. Among the students with the highest severity of fluorosis, 98.6% belonged to the lowest social bracket (> B2), 91.5% were born and had always lived in Teresina, 94.4% consumed water from the fluoridated public supply, 76% used toothpaste for children and 64% of mothers reported that they swallowed toothpaste. The prevalence of fluorosis was high, though the severity was low in individuals exposed to fluoridation since birth.

Odontoma complexo extenso causando assimetria facial: relato de caso / Large complex odontoma with facial asymmetry: a case report

Odontoma é um tumor de malformação, em que esmalte e dentina e, às vezes, o cemento estão presentes. É o tumor odontogênico mais comum, representando 67% de todos os tumores odontogênicos. Ocorre em crianças, adolescentes e adultos jovens. Clinicamente, são frequentemente associados a lesões assintomáticas e a alterações na erupção da dentição decídua ou permanente. O objetivo deste trabalho é relatar um caso de odontoma complexo na região posterior de maxila que atingiu grande extensão, tendo como consequência assimetria facial. Paciente de iniciais JLD, gênero masculino, 25 anos de idade, procurou atendimento no serviço de cirurgia e traumatologia buco-maxilo-facial do Hospital Getúlio Vargas em Teresina - PI, apresentando queixa de assimetria facial no lado esquerdo. Ao exame clínico observou-se uma massa gengival hiperplasiada de consistência endurecida, com coloração normal. A radiografia panorâmica mostrou uma área mista radiolúcida - radiopaca, de forma oval, provocando reabsorções de raízes dos 2º e 3º molares esquerdos superiores. Na tomografia computadorizada, observou-se lesão mista de contorno parcialmente delimitado. A exérese da lesão foi realizada por meio da biópsia excisional. Os cortes histológicos revelaram fragmentos de neoplasia benigna odontogênica, confirmando o diagnóstico como Odontoma complexo. A obtenção do resultado cirúrgico satisfatório com o mínimo de complicações é o objetivo.

The odontoma is a tumor of malformation in which enamel, dentin, and sometimes cementum are present. It is the most common odontogenic tumor, accounting for 67% of all odontogenic tumors. It occurs in children, adolescents and young adults. Clinically, these lesions are often asymptomatic and associated with changes in the eruption of the deciduous or permanent teeth. The objective of this study was to report a case of a complex odontoma of substantial proportions in the posterior maxilla with the resulting facial asymmetry. JLD, a 25-year-old male sought treatment in the Department of Traumatology and Maxillofacial Surgery at Getulio Vargas Hospital in Teresina-PI, complaining of facial asymmetry on the left side. The clinical examination revealed a hardened gingival hyperplastic mass with a normal color. The panoramic radiograph showed an oval mixed radiolucent/radiopaque area, causing resorption of roots of the second and third upper left molars. Computed tomography revealed a mixed lesion with partially defined contours. The removal of the tumor was performed by excision biopsy. The histological sections revealed fragments of a benign odontogenic neoplasia, confirming the diagnosis of complex odontoma. The goal is to obtain a satisfactory surgical result with a minimum of complications.