Surfactant for the treatment of respiratory distress syndrome in very low birth weight infants at a level 2 hospital: A descriptive retrospective cohort study - safety and efficacy.

Respiratory distress syndrome (RDS) is common and is a leading cause of death in pre-term infants. The purpose of our study is to describe the demographics and incidence of adverse events in very low birth weight (VLBW) pre-term infants with RDS treated with surfactant at George, a level 2 Hospital in the Western Cape Province of South Africa. This was a retrospective observational study. We conducted an electronic folder review of infants with a birth weight of 800-1200 g treated during the study period 2017-2019 at George Regional Hospital. Outborn infants and those with congenital abnormalities were excluded. The total number of patients included in the study was 66. The mortality rate was 25.8% (17/66). The incidence of bronchopulmonary dysplasia was 6% (4/66). Our study showed that the outcomes of VLBW infants treated with surfactant at level 2 hospitals are comparable to South African central hospitals.

An assessment of safe injection practices in health facilities in Swaziland.

OBJECTIVES: To determine the magnitude and causes of unsafe injection practices in Swaziland. DESIGN: A safe injection practices questionnaire was administered and injection practice was observed. SETTING: A selected variety of health facilities in Swaziland. SUBJECTS: Health workers in each facility. OUTCOME MEASURES: Unsafe injection and collection for disposal practices. RESULTS: All injections observed involved disposable syringes. Although all injections were given at the correct site, using the correct dosage and equipment, unsafe injection technique was observed. Needles were changed on the same syringe at 8 facilities (31%) and syringes and needles were reused at 2 facilities (8%). Recapping of needles after use occurred at 8 facilities (31%). More than one-quarter of nurses reported having pricked their finger in the previous 6 months; in almost half of these cases this was after administration of an injection. Seven nurses (25%) recalled seeing a case of an abscess or a mild adverse event following an injection in the previous 12 months. Interviewers observed used syringes and needles being placed in a safe container in three-quarters of facilities. Almost all respondents reported that syringes and needles were buried or burned. CONCLUSIONS: Auto-disable syringes should be used for all routine and supplemental vaccination. The increased cost of auto-disable syringes represents only a small increase in the national Expanded Programme on Immunisation (EPI) budget.

Adolescents' views on decision-making regarding risky sexual behaviour.

PURPOSE: To explore adolescents' views regarding risky sexual behaviour who were aged between 13 and 19 years. METHODS: A purposive sample was drawn from adolescents who were participating in workshops, organized by the Ministry of Health and Social Welfare. The sample consisted of a mix of in-school and out-of-school adolescents aged between 13 and 19 years. The overall aim of the workshops was to explore adolescents' views on decision-making regarding risky sexual behaviour. The educational status of participants lay between grades 0 and 12. A total of 24 focus group discussions were conducted, six in each of the four regions of Swaziland (Manzini, Hhohho, Lubombo and Shiselweni). Each group consisted of 6-12 participants. All focus group discussions were audiotaped and later transcribed. FINDINGS: The following four major themes emerged from content analysis: sexual behaviour, age at first intercourse, peer pressure and trust in the relationship. These were all found to be important factors in decision-making for risky sexual behaviours. CONCLUSIONS: Obtaining a sexual history, motivation to use condoms, guidance and counselling on ways to reduce adolescents' risk of sexual exploitation, and peer education programmes, are all of importance when aiming to reduce risky sexual behaviour. RECOMMENDATION: Adolescents should receive positive reinforcement for responsible sexual behaviour including abstinence and, where appropriate, use of active birth control.

Missed opportunities for vaccination in health facilities in Swaziland.

OBJECTIVES: To determine whether potential exists to increase vaccination coverage in Swaziland by reducing missed opportunities. DESIGN: The standard World Health Organisation Expanded Programme on Immunisation (WHO EPI) protocol for assessing missed opportunities for vaccination was used to conduct this study. It involved client exit interviews and review of health cards. SETTING: Selected variety of health facilities in Swaziland. SUBJECTS: Children less than 2 years of age and women of child-bearing age exiting each facility. OUTCOME MEASURES: Children and women eligible for vaccination exiting sampled health facilities. RESULTS: Fifty-four per cent of eligible children less than 2 years of age were missed for vaccination. This constitutes 26% of all children less than 2 years old leaving the facilities studied. Almost 100% of eligible women of childbearing age were missed for vaccination, constituting 88% of women leaving the study facilities. The distribution of the proportion of missed opportunities varied considerably between regions and health facility types. Missed opportunities occurred more frequently among those children requiring the first dose of all antigens and this may be linked to the high proportion of children missed for vaccination who did not possess a health card. Missed opportunities were more likely to occur in facilities providing integrated services. CONCLUSIONS: The frequent attendance at health facilities of the target group presents a valuable opportunity to increase vaccination coverage through avoidance of missed opportunities. All regions need to set vaccination coverage targets and develop plans to increase coverage, which should include strategies to ensure that all health workers routinely screen all clients for eligibility and vaccinate as required.

Targeted intervention research studies on sexually transmitted diseases (STD): methodology, selected findings and implications for STD service delivery and communications.

OBJECTIVE: To report the findings of qualitative studies designed for use in improving sexually transmitted disease (STD) programs. The studies explore illness conceptions and treatment behaviors for STD in five African countries. These targeted intervention research (TIR) studies were performed on clinic-based and community-based samples in representative communities and utilized a variety of qualitative research methods (e.g. in-depth and key informant interviews, focus group discussions). FINDINGS: Study findings revealed that community members' explanations of symptoms, classification of illnesses, and perceptions of whether symptoms are pathological or serious influence individual health-care-seeking behaviors. Data also showed that local terms for STD are often disparaging and do not fit into biomedical designations. STD patient care-seeking frequently reflects an ordered, albeit loosely constructed, process of elimination in pursuit of symptom relief, wherein alternative treatments are tried and proven effective or abandoned. CONCLUSIONS: The TIR studies highlight the importance of community-specific strategies aimed at increasing prompt care seeking at qualified biomedical facilities. Information from study data should lead programs to sensitize health professionals to community understanding about STD and to design services and communication programs that are meaningful and appropriate to local contexts.

PIP: Targeted intervention research (TIR) studies were performed in five African countries (Senegal, Ethiopia, Benin, Morocco, and Swaziland) to improve the utilization of a community perspective in sexually transmitted disease (STD) programs. TIR, conducted by program managers with the aid of a multidisciplinary technical advisory group, examines factors at five levels of analysis (individual, social network, organization, community, and policy) through a variety of qualitative methods. The TIR studies indicated that patients' conceptions of normal versus abnormal health are fundamental to the process of interpreting symptoms and subsequently seeking care. The interpretation of STD symptoms varied across settings (e.g., vaginal lesions and discharge were considered signs of healing in Morocco and Benin), but increasing pain and discomfort were key triggers to seeking treatment. The concept of sexual transmission was blended with other causes such as violation of religious or moral codes, consumption of certain foods, and supernatural forces. Care-seeking tended to reflect an ordered yet loosely constructed process of elimination in pursuit of symptom relief, beginning with alternative regimens. Barriers to biomedical STD care included the need for husband's permission, costs, confidentiality concerns, long waits in public clinics, and fear of judgmental health provider attitudes. Overall, the findings highlight the importance of location-specific strategies aimed at increasing prompt care-seeking at qualified biomedical facilities.