RESUMO
Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized. We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides for exacerbations of Pseudomonas aeruginosa infection. Three additional cases have also been observed. Investigations in two patients have revealed excessive renal loss of magnesium. It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.
Assuntos
Antibacterianos/efeitos adversos , Fibrose Cística/complicações , Deficiência de Magnésio/induzido quimicamente , Infecções por Pseudomonas/complicações , Infecções por Pseudomonas/tratamento farmacológico , Tobramicina/efeitos adversos , Doença Aguda , Pré-Escolar , Feminino , Humanos , Túbulos Renais/efeitos dos fármacos , Magnésio/sangue , Pseudomonas aeruginosaRESUMO
Confronted with a child deteriorating during treatment of diabetic ketoacidosis, Godfrey Nyamugunduru and Helen Roper describe how the child's management was complicated by gross hyperlipidaemia. At the point where the child's condition was deteriorating despite conventional management we invited two experts-Gilbert R Thompson and J I Mann-to suggest a course of action. The original authors then describe how they did manage the case, and our experts comment again.
