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1.
J Psychiatr Ment Health Nurs ; 22(10): 773-83, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26459938

RESUMO

ACCESSIBLE SUMMARY: What is known on the subject? Stress can impact students on mental health nurse training. This can have implications at the individual level (e.g. their own mental health) and at the level of the organization (e.g. sickness absence and attrition). What this paper adds to existing knowledge? We interviewed 12 mental health nursing students regarding the stress they experienced during training. Participants described how the academic demands can at times be unbearable during clinical placements. There were also issues with 'being a student' on some placements, with participants describing negative attitudes towards them from staff. The younger participants reported feeling overwhelmed on their initial placements and described some of the main challenges of mental health work for them. Raising concerns about the quality of care on wards was also described as particularly challenging for the students. What are the implications for practice? This paper can be useful to help training providers support mental health nursing students. Recommendations include reducing academic demands during clinical placements and extending and promoting existing support services beyond normal 9 am-5 pm working hours, even if these services are limited. Younger students could be better supported by being allocated to the more well-resourced placements in the early stages of their training. Raising awareness among staff of the tasks students can and cannot perform can help improve staff/student relations. Finally, students should be educated about the issues around raising concerns on placements to help the government's drive for a more open and transparent National Health Service (NHS). INTRODUCTION: Previous studies investigating stress in nursing students focus on general nursing students or adopt quantitative measures. PURPOSE OF STUDY: A qualitative study focusing specifically on mental health nursing students is required. METHOD: One-to-one interviews were carried out with mental health nursing students (n = 12). Data were thematically analysed. RESULTS: Participants reported unreasonable demands during clinical blocks, and described how control/support is lowest on placements with staff shortages. Negative attitudes towards students from staff and related issues were also discussed. Younger participants described struggling with mental health work during the early stages of training. DISCUSSION: Training providers should strive to provide adequate support to students to help them manage stress during training. Implications for practice Academic demands should be reasonable during clinical blocks and support services outside normal working hours should be available for students, even if these are limited in scope. Greater consideration to the allocation of placements for younger students in the mental health branch could be helpful. Furthermore, staff on placements should be aware of the tasks students can and cannot perform, to help improve staff/student relations. Educating students on the issues of raising concerns can help the government's drive for a more open and transparent National Health Service (NHS).


Assuntos
Bacharelado em Enfermagem , Enfermagem Psiquiátrica/educação , Estresse Psicológico/psicologia , Estudantes de Enfermagem/psicologia , Adulto , Feminino , Humanos , Entrevista Psicológica , Masculino , Pesquisa em Educação em Enfermagem , Pesquisa Qualitativa , Adulto Jovem
2.
Allergy ; 59 Suppl 78: 7-11, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15245350

RESUMO

BACKGROUND: There has been a world-wide increase in the prevalence of atopic diseases. These atopic diseases, including asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis, are common in childhood and create a challenge of management for physicians and parents. METHODS: MEDLINE was searched for articles related to atopy, allergy asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis. RESULTS AND CONCLUSIONS: The conditions of asthma, allergic rhinoconjunctivitis and atopic eczema/dermatitis cause very significant burdens regarding the discomfort to the affected individual, management problems for the parent and physician and the economic cost to the family and the nation.


Assuntos
Dermatite Atópica , Hipersensibilidade Respiratória , Asma/complicações , Asma/economia , Asma/epidemiologia , Criança , Conjuntivite Alérgica/complicações , Conjuntivite Alérgica/economia , Conjuntivite Alérgica/epidemiologia , Efeitos Psicossociais da Doença , Dermatite Atópica/complicações , Dermatite Atópica/economia , Dermatite Atópica/epidemiologia , Humanos , Prevalência , Qualidade de Vida , Hipersensibilidade Respiratória/complicações , Hipersensibilidade Respiratória/economia , Hipersensibilidade Respiratória/epidemiologia , Rinite Alérgica Perene/complicações , Rinite Alérgica Perene/economia , Rinite Alérgica Perene/epidemiologia , Rinite Alérgica Sazonal/complicações , Rinite Alérgica Sazonal/economia , Rinite Alérgica Sazonal/epidemiologia , Estados Unidos/epidemiologia
3.
J Pediatr ; 139(2): 278-83, 2001 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11487757

RESUMO

OBJECTIVE: To analyze school attendance and school achievement as outcomes of the care of children with asthma. METHODS: A previously identified Rochester, Minnesota, cohort of children with asthma and age- and sex-matched children without asthma were studied. School attendance, standardized achievement test scores, grade point average, grade promotion, and class rank of graduating students for children with asthma and control subjects were obtained from the Rochester Public School system. RESULTS: Children with asthma (n = 92) and age- and sex-matched non-asthmatic control subjects with 640 school-years of observation were studied. Children with asthma had 2.21 (95% CI, 1.41 to 3.01) more days absent than children without asthma. There was no significant difference in standardized achievement test scores (reading percentile difference 1.22% [95% CI, -3.68 to 6.12], mathematics percentile difference 2.36% [95% CI, -2.89 to 7.60], language percentile difference 2.96% [95% CI, -4.03 to 7.15]). There was no significant difference in grade point average, grade promotion, or class rank of graduating students. CONCLUSION: In this community, although children with asthma had 2 excess days of absenteeism, the school performance of children with asthma was similar to that of children without asthma.


Assuntos
Absenteísmo , Asma , Avaliação Educacional , Estudos de Casos e Controles , Criança , Pré-Escolar , Coleta de Dados , Família , Feminino , Humanos , Masculino , Minnesota
5.
Ann Allergy Asthma Immunol ; 82(1): 29-32, 1999 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-9988203

RESUMO

BACKGROUND: Glucocorticoids have been used to treat asthma since the 1950s; however, their adverse systemic effects have limited their duration of use and dosage. Unfortunately, many patients with severe asthma often require oral glucocorticoids in addition to inhaled glucocorticoids. Alternatives to glucocorticoids have been sought with mixed success. Recently, lidocaine has been added to the list of potent glucocorticoid sparing agents for the treatment of severe asthma. OBJECTIVE: We report the first group of pediatric patients with severe asthma treated with nebulized lidocaine. METHODS: The study was performed in an open manner with 6 severely asthmatic patients followed in the Pediatric Allergy and Immunology Section, Mayo Clinic. The only intervention was the institution of nebulized lidocaine (0.8 mg/kg/dose to 2.5 mg/kg/dose t.i.d to q.i.d). The average daily steroid requirement was followed during the administration of the nebulized lidocaine. RESULTS: During a mean of 11.2 months of therapy (range 7 to 16 months) 5 of the 6 patients completely discontinued their oral glucocorticoids within an average time of 3.4 months (range 1 to 7 months). CONCLUSIONS: After further study, lidocaine may prove to be the first non-toxic, steroid alternative to patients with severe steroid-dependent asthma.


Assuntos
Asma/tratamento farmacológico , Lidocaína/administração & dosagem , Administração por Inalação , Adolescente , Hiperfunção Adrenocortical/tratamento farmacológico , Criança , Feminino , Glucocorticoides/efeitos adversos , Glucocorticoides/uso terapêutico , Humanos , Masculino , Nebulizadores e Vaporizadores , Projetos Piloto
6.
Postgrad Med ; 104(3): 127-36, 139, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9742908

RESUMO

Anti-inflammatory agents are the first-line treatment for controlling mild persistent, moderate persistent, and severe persistent asthma. The choice of drug and dosage must be individualized to the patient. In general, the glucocorticoids are widely accepted as the most potent and preferred asthma treatment in most adults and some children. Cromolyn, because of its safety and availability in a nebulized form, is the first-line treatment in most young children. The leukotriene inhibitors appear to be effective in mild asthma, but further clinical studies are needed to determine their role more precisely. As the mechanisms of inflammation in asthma are further defined, new pharmaceutical products will be developed to aid in arresting this process.


Assuntos
Antiasmáticos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Asma/tratamento farmacológico , Adulto , Asma/classificação , Asma/fisiopatologia , Criança , Cromolina Sódica/uso terapêutico , Glucocorticoides/uso terapêutico , Humanos , Indóis , Inflamação/etiologia , Fenilcarbamatos , Sulfonamidas , Compostos de Tosil/uso terapêutico
7.
Mayo Clin Proc ; 73(3): 225-9, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9511779

RESUMO

OBJECTIVE: To reassess airborne pollen counts and to study spore counts by volumetric collection in Rochester, Minnesota. MATERIAL AND METHODS: Samples of pollen and spores were collected from the top of a six-story building in downtown Rochester by use of a rotational rod sampler, which was activated for 30 seconds every 10 minutes for 24 hours a day, 5 days a week, from mid-April to mid-October 1992 through 1995. Particles were stained with Calberla's fluid and viewed microscopically by transmitted light. Identifications were substantiated by comparison with field-collected "known" materials and standard reference guides. Data were expressed as "particles retained/cubic meter of air sampled." RESULTS: Because the methods of collection varied, only qualitative comparisons could be made with a study done in Rochester more than 3 1/2 decades earlier. For tree pollens, a similar progression of appearance and seasonal duration were noted for most species. Alder (Alnus), willow (Salix), and hickory-pecan (Carya), however, were found to have distinctly longer seasons, and walnut (Julgans) was detected 2 weeks earlier in the season. The most frequently detected tree pollen had changed from oak (Quercus) to apple and crab apple (Malus), which was not reported at all previously. Ragweed (Ambrosia) was still found to peak at the end of August and had a similar duration. Study of grass and nettle pollen as well as the Amaranthaceae-Chenopodiaceae complex yielded findings similar to those in the prior investigation. Fungal spores were detected from April through October and represented a substantial percentage of the airborne allergens; Cladosporium, ascospores, and basidiospores were the most common. CONCLUSION: Volumetric assessment of airborne pollen and spore levels in Rochester, Minnesota, yielded useful information for clinicians in southern Minnesota that could help direct skin test selection.


Assuntos
Ar/análise , Pólen , Esporos , Minnesota
8.
Ann Allergy Asthma Immunol ; 79(2): 91-9; quiz 99-101, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9291412

RESUMO

LEARNING OBJECTIVES: Reading this article will enable health care providers to recognize and to diagnose paroxysmal sneezing, sighing dyspnea, habit cough, and vocal cord dysfunction and to reinforce their knowledge of the epidemiology, etiopathology, clinical features, and treatment of these disorders. DATA SOURCES: The literature was reviewed using a MEDLINE search for information relating to the above-mentioned disorders. Indexing terms used included psychogenic wheezing, vocal cord dysfunction, functional respiratory disorders, sighing dyspnea, paroxysmal sneezing, habit cough, and psychogenic stridor. Review was restricted to English language articles from 1966 onward, with cross-referencing to obtain older references. STUDY SELECTION: All human studies that clearly identified the above-mentioned disorders as being nonorganic on the basis of historic and appropriate laboratory evaluation were reviewed. No studies were rejected on the basis of subject age, although special emphasis was given to articles concerning children and adolescents (<18 years old). Of all initially identified studies, 95% fulfilled the inclusion criteria. RESULTS: Functional respiratory disorders are common and affect mostly children, adolescents, and young adults, resulting in considerable morbidity and contributing significantly to patient and physician cost and frustration. A history of a psychiatric disorder with temporally related psychogenic stressors is frequently found. Professionals disagree on the technical classification of some of these conditions (ie, psychosomatic versus somatoform), but there is agreement that treatment directed toward underlying stressors should be the cornerstone of therapy. CONCLUSIONS: Functional respiratory disorders must be considered in patients with atypical symptoms, especially those resistant to conventional therapy. Possible psychogenic stressors must be inquired into and, when identified, treated in a multidisciplinary manner. This may involve reassurance regarding the absence of significant organic abnormality, counseling, and occasional recourse to formal psychiatric intervention.


Assuntos
Transtornos Respiratórios/fisiopatologia , Transtornos Respiratórios/psicologia , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Transtornos Psicofisiológicos
9.
Pediatr Pulmonol ; 23(1): 55-61, 1997 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-9035199

RESUMO

We describe a male infant with biopsy-confirmed interstitial lung disease (ILD) who responded to chloroquine, after he failed to improve on oral corticosteroids or cyclophosphamide. The infant presented at 8 days of age with respiratory distress and cyanosis. Lung biopsy at 8 weeks of age was consistent with desquamative interstitial pneumonitis (DIP). He was treated with corticosteroids at 2 weeks of age because of a family history of two siblings who died during infancy and who had DIP on postmortem examination. At 8.5 months, our patient was treated with cyclophosphamide because of lack of response to corticosteroids therapy. At 14 months of age, he began treatment with chloroquine in addition to corticosteroids and had a dramatic response within 3 weeks. The patient has been maintained successfully on continuous treatment with chloroquine alone for more than 9 years since this treatment was started.


Assuntos
Cloroquina/uso terapêutico , Doenças Pulmonares Intersticiais/tratamento farmacológico , Humanos , Recém-Nascido , Doenças Pulmonares Intersticiais/genética , Masculino
10.
Ann Allergy Asthma Immunol ; 76(1): 1-13; quiz 13-5, 1996 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8564622

RESUMO

OBJECTIVE: The purpose of this article is to review the medical history and physical examination of the asthmatic patient. DATA SOURCES: English references identified from relevant articles and book chapters, experts, and MEDLINE search, using "asthma," "physical diagnosis," and "medical history." STUDY SELECTION: Clinical studies of the medical history or physical examination in subjects with respiratory disease were selected for review. RESULTS: Symptoms such as wheezing, chest tightness and difficulty in taking a deep breath suggest asthma, while symptoms such as gasping, smothering or air hunger suggest alternative diagnoses. Symptoms of asthma correlate poorly with airway obstruction in one-third to one-half of asthmatic patients. Respiratory signs such as wheezing, breath sound intensity, forced expiratory time, accessory muscle use, respiratory rate and pulsus paradoxus correlate roughly with airway obstruction. However, clinicians disagree on the presence or absence of respiratory signs 55% to 89% of the time. Furthermore, physicians correctly predict pulmonary function based on history and physical examination only about half the time, and correctly diagnose asthma based on the clinical examination 63% to 74% of the time. CONCLUSIONS: The medical history and physical examination are moderately effective in diagnosing asthma and estimating its severity. Objective measures of lung function are necessary for the accurate diagnosis of asthma.


Assuntos
Asma/diagnóstico , Humanos , Anamnese , Exame Físico , Testes de Função Respiratória
11.
N Engl J Med ; 331(23): 1537-41, 1994 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-7969322

RESUMO

BACKGROUND: Reports of an increase in asthma-related mortality have been based on studies of death certificates from the general U.S. population on which asthma was listed as an underlying cause of death. We addressed the issue in a different way by analyzing long-term survival in a defined, population-based cohort of patients with asthma. METHODS: We identified all residents of Rochester, Minnesota, in whom asthma was diagnosed from January 1, 1964, through December 31, 1983, by reviewing the medical records of all patients with asthma and associated diagnoses, using explicit predefined criteria. The patients' vital status at last follow-up was ascertained. Medical records, death certificates, and autopsy reports were reviewed to classify deaths as due either to asthma or to other conditions. RESULTS: We identified 2499 patients with definite or probable asthma. The mean duration of follow-up was 14 years (range, 0 to 29). There were 140 deaths during 32,605 person-years of follow-up. Overall survival was not significantly different from the survival that was expected for residents of Rochester. Survival was less than expected in patients who were 35 years of age or older when their asthma was diagnosed and who also had another lung disease (predominantly chronic obstructive pulmonary disease). Four percent of all deaths in the study cohort were due to asthma, and all were among adults. Survival was not related to the year of onset of asthma. CONCLUSIONS: Survival among patients with asthma but no other lung disease was not significantly different from expected survival. However, patients 35 or older who had asthma associated with chronic obstructive pulmonary disease did have worse than expected survival. Asthma was classified as the cause of death in only 4 percent of the patients, and there was no evidence of an increased risk of death among patients with a more recent diagnosis of asthma. These results provide assurance that community-based patients with asthma usually have a good prognosis.


Assuntos
Asma/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Asma/complicações , Asma/mortalidade , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Seguimentos , Humanos , Pneumopatias Obstrutivas/complicações , Pneumopatias Obstrutivas/epidemiologia , Pneumopatias Obstrutivas/mortalidade , Masculino , Pessoa de Meia-Idade , Minnesota/epidemiologia , Análise Multivariada , Prognóstico , Risco , Taxa de Sobrevida
12.
Minn Med ; 76(9): 31-3, 1993 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8413087

RESUMO

Asthma is currently considered by many to be a disease out of control. The prevalence and severity of asthma have increased in recent years, especially in children. Asthma is a very diagnosable condition. Better methods for treatment and monitoring now exist. It is hoped that with the implementation of expanded knowledge of asthma, this very common condition in childhood can be brought under better control.


Assuntos
Asma/etiologia , Asma/diagnóstico , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Criança , Pré-Escolar , Terapia Combinada , Exposição Ambiental/efeitos adversos , Humanos , Lactente , Fatores de Risco
13.
JAMA ; 269(15): 1947-52, 1993 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-8464126

RESUMO

OBJECTIVE: To quantify the reliability of death certificate data concerning asthma. DESIGN: The complete medical records of decedents were reviewed by a physician certified in allergy and pulmonology who determined the cause of death without having access to the original death certificate. Disagreements between the death certificate and the reviewer were adjudicated by an expert panel. SETTING: The community of Rochester, Minn. PATIENTS: The mortality cohort included 339 deaths from a larger cohort of 5241 Rochester residents who received medical treatment for asthma between 1964 and 1983. MAIN OUTCOME MEASURES: Kappa coefficients were used to measure agreement beyond that expected by chance between the reviewer and the death certificate. The sensitivity and specificity of the death certificate diagnosis of asthma were calculated against the standard of the reviewer/panel diagnosis. RESULTS: Death certificates reported asthma as an immediate or underlying cause of death in 22 instances (6%), whereas the reviewer/panel identified asthma in 53 cases (16%). In four cases, the death certificate listed asthma and the panel identified another cause of death. The death certificate had a sensitivity of 42% and a specificity of 99% compared with the reviewer/panel. Agreement between death certificates and the reviewer was not influenced by whether an autopsy was performed. CONCLUSIONS: Death certificate diagnosis of asthma as an underlying cause of death had a low sensitivity but a high specificity. Increases in mortality due to asthma are not likely caused by false-positive diagnoses of asthma as an underlying cause of death. Asthma mortality rates, determined from death certificate data, may indeed underestimate actual asthma-related mortality.


Assuntos
Asma/mortalidade , Atestado de Óbito , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Asma/diagnóstico , Causas de Morte , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Lactente , Masculino , Prontuários Médicos/estatística & dados numéricos , Pessoa de Meia-Idade , Minnesota/epidemiologia , Controle de Qualidade , Sensibilidade e Especificidade
15.
Am Rev Respir Dis ; 146(4): 888-94, 1992 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-1416415

RESUMO

To determine whether the incidence of asthma had increased in Rochester, Minnesota, from January 1, 1964 through December 31, 1983, we used a population-based computer-linked medical diagnosis system to identify individual medical records with diagnosis of asthma or other conditions mimicking asthma. All records were reviewed using explicit predetermined diagnostic criteria; we identified 3,622 incident cases of asthma, including definite asthma (n = 1,547), probable asthma (n = 952), and single wheezing episodes (n = 1,123). The annual age- and sex-adjusted incidence of definite + probable asthma rose from 183 per 100,000 in 1964 to 284 per 100,000 in 1983. This rise was entirely accounted for by increased incidence rates in children and adolescents (age range, 1 to 14 yr); incidence rates for infants younger than 1 yr of age and for adults remained constant. For definite + probable asthma cases, the incidence rates for males were higher than for females from infancy through 9 yr of age and for persons older than 50; incidence rates for females were higher than for males from 15 through 49 yr of age. The median age at onset was 3 yr for males and 8 yr for females. We conclude that asthma begins in early childhood, with a higher incidence and earlier onset in males, and that the increase in incidence rates seen from 1964 to 1983 occurred only in children and in adolescents.


Assuntos
Asma/epidemiologia , Fatores Etários , Estudos de Coortes , Feminino , Humanos , Incidência , Masculino , Registro Médico Coordenado , Minnesota/epidemiologia , Estudos Retrospectivos , Fatores Sexuais
16.
J Clin Epidemiol ; 45(9): 1013-20, 1992 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-1432015

RESUMO

Interobserver variability during the data collection for a large retrospective study of asthma was assessed. After extensive training by three physician investigators, two nurses collected study data from existing medical records using an explicit protocol. At four time intervals, samples of records already abstracted by one nurse were reviewed and re-abstracted by another nurse assigned to the project. The unweighted kappa coefficient was used to evaluate observer reliability. Most of the kappa coefficients were > or = 0.6, suggesting good to excellent agreement. Agreement was highest for demographic, clinical and medication variables, while judgement variables had the lowest kappa coefficients. The well known dependence of kappa on the prevalence of the variable studied was evident in these data. We strongly recommend periodic monitoring of observer reliability in any study using more than one individual to collect data to ensure reliable data collection.


Assuntos
Asma/epidemiologia , Coleta de Dados/normas , Prontuários Médicos/estatística & dados numéricos , Variações Dependentes do Observador , Feminino , Humanos , Masculino , Minnesota/epidemiologia , Estudos Retrospectivos
17.
Mayo Clin Proc ; 66(12): 1238-47, 1991 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-1749292

RESUMO

Childhood sinusitis is difficult to diagnose. It is classified on the basis of duration of inflammation--acute or chronic--and cause of inflammation--infectious or noninfectious. Infectious sinusitis is often a result of obstruction of the osteomeatal complex. Inflammation in noninfectious sinusitis is similar to the inflammatory changes detected in respiratory mucosa of patients with asthma. Acute sinusitis is primarily an infectious process similar to a prolonged infection of the upper respiratory tract. Plain radiography has limited value for the diagnosis of acute sinusitis in children. The most effective treatment of acute sinusitis is administration of a beta-lactamase-resistant antibiotic. Chronic sinusitis may be infectious, noninfectious, or both. Coronal computed tomography of the sinuses and nasal endoscopy are the preferred methods for determining the presence of chronic sinusitis. When physicians prescribe therapy for chronic sinusitis, they need to consider whether the underlying cause is infectious, noninfectious, or both. Treatment of chronic infectious sinusitis is most effective when a beta-lactamase-resistant antibiotic is administered. Chronic noninfectious sinusitis may respond to topically intranasally applied corticosteroids. If medical treatment fails to resolve the disease within 3 months, surgical intervention may be necessary. Finally, although an association between asthma and sinusitis exists, a cause-and-effect relationship has not been established.


Assuntos
Pediatria/métodos , Sinusite , Doença Aguda , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Doença Crônica , Endoscopia , Humanos , Lactamas , Sinusite/classificação , Sinusite/diagnóstico , Sinusite/terapia , Tomografia Computadorizada por Raios X
18.
Chest ; 100(2): 556-60, 1991 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1864138

RESUMO

We describe a 4-year-old boy who died of an unusual generalized pulmonary lymphatic proliferation. His condition cannot clearly be categorized with any of the previously described pulmonary lymphatic disorders.


Assuntos
Pneumopatias/patologia , Transtornos Linfoproliferativos/patologia , Pré-Escolar , Seguimentos , Humanos , Neoplasias Pulmonares/patologia , Linfangiectasia/patologia , Linfangioma/patologia , Sistema Linfático/patologia , Masculino , Músculo Liso/patologia
19.
Ann Allergy ; 66(4): 278-82, 285, 1991 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-1901691

RESUMO

Cough-type asthma is a well-defined entity. The patients typically have a chronic, nonproductive cough that is exacerbated by exercise and upper respiratory tract infections. Bronchial provocation maneuvers are helpful in diagnosing cough-type asthma in older children and adults. Bronchodilators are the mainstay of therapy, although some patients may require cromolyn sodium or inhaled corticosteroids. The natural history of this process suggests that approximately a third to a half of these patients may progress to "classical" asthma with wheezing.


Assuntos
Asma/complicações , Tosse/complicações , Corticosteroides/uso terapêutico , Asma/diagnóstico , Asma/tratamento farmacológico , Asma/patologia , Tosse/diagnóstico , Tosse/tratamento farmacológico , Tosse/patologia , Cromolina Sódica/uso terapêutico , Humanos
20.
N Engl J Med ; 324(6): 359-63, 1991 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-1987459

RESUMO

BACKGROUND: Exposure to airborne spores of the common mold Alternaria alternata has been implicated in asthma attacks. Such exposure is particularly frequent in the Midwest during the summer and fall months. To determine the role of A. alternata in triggering severe asthma attacks, we investigated the cases of 11 patients with asthma who had sudden respiratory arrest and determined the frequency of sensitivity to this allergen in these patients. METHODS: The 11 patients (age range, 11 to 25 years) with initial episodes of respiratory arrest, which was fatal in 2 patients, were identified in the course of their care in our pediatric and adult clinical allergy practice and by a retrospective review of all Mayo Clinic records of patients with severe asthma cared for between 1980 and 1989. Skin-test reactivity to A. alternata and levels of IgE antibody against this mold in the 11 patients were compared with those in 99 matched controls with asthma who had no history of respiratory arrest. RESULTS: All the patients came from the upper Midwest, and the episodes of respiratory arrest occurred in the summer or early fall. Ten of the 11 patients with asthma who had respiratory arrest (91 percent) had positive skin-puncture tests for sensitivity to alternaria, as compared with 31 percent of the controls (P less than 0.001), and the serum levels of IgE antibodies to alternaria were elevated in all 9 patients tested. Among the covariates we examined (age, sex, and distance from the Mayo Clinic), only age was a significant confounder. After adjustment for age, alternaria skin-test reactivity was found to be associated with an increase of approximately 200-fold in the risk of respiratory arrest (adjusted odds ratio, 189.5; 95 percent confidence interval, 6.5 to 5535.8). CONCLUSIONS: Exposure to the aeroallergen A. alternata is a risk factor for respiratory arrest in children and young adults with asthma.


Assuntos
Alérgenos , Alternaria/imunologia , Asma/fisiopatologia , Adolescente , Adulto , Anticorpos Antifúngicos/análise , Criança , Exposição Ambiental , Feminino , Humanos , Imunoglobulina E/análise , Masculino , Insuficiência Respiratória/imunologia , Fatores de Risco , Estações do Ano , Testes Cutâneos , Esporos Fúngicos/imunologia
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