The value of publicly engaged podcasting in human biology.

Podcasting about science may be popular, but does it motivate engagement? The Human Biology Association and American Journal of Human Biology (AJHB) cosponsor a podcast that highlights recent articles. We hypothesized that AJHB articles discussed on the podcast (n = 42) receive more online views than other articles from the same issues. We used Student's t-tests to compare mean article views and found podcasted articles received more views, but the difference was not significant. When extreme outliers were removed, podcasted articles had over twice the views of control articles (p = .04), indicating that journal-affiliated podcasting can increase science engagement.

Human cold adaptation: An unfinished agenda v2.0.

BACKGROUND: Research on human extreme cold climate adaptations has benefitted from a recent resurgence since Ted Steegmann laid out his Human Cold Adaptation Agenda in 2007. Human biologists have drastically expanded our knowledge in this area during the last 15 years, but we still have a great deal more work to do to fulfill the cold climate adaptation agenda. METHODS: Here, I follow Steegmann's example by providing a review of cold climate adaptations and setting forth a new, expanded agenda. RESULTS: I review the foundational work on cold climate adaptations including classic Bergmann, Allen, and Thomson rules as well as early work assessing metabolic differences among Indigenous cold climate populations. From there, I discuss some of the groundbreaking work currently taking place on cold climate adaptations such as brown adipose tissue (a heat generating organ), physical activity levels, metabolic rates, and behavioral/cultural mechanisms. Finally, I present a path forward for future research with a focus on some of the basic extreme cold adaptations as well as how human biologists should approach the effects of climate change on human health and well-being, particularly within a cold climate context. CONCLUSION: The Arctic has felt the dramatic effects of climate change sooner and more acutely than other parts of the world, making it an ideal location for studying both cold climate adaptations and climate change resilience. Human biologists have a great deal to contribute to the conversation on not only adaptations to extreme cold, but also the ways in which climate change is being embodied by cold climate populations.

When the cold gets under your skin: Evidence for brown adipose tissue activity in Samoan adults.

OBJECTIVES: Brown adipose tissue (BAT) is a heat-producing organ aiding nonshivering thermogenesis (NST) during cold stress. Due to its potential cold-adaptive role BAT has been predominantly studied in cold and temperate climate populations, but not among warm-climate adults. This work explores if BAT activity can be inferred in Samoans. MATERIALS AND METHODS: We inferred BAT activity by comparing metabolic rate and surface heat dissipation using indirect calorimetry and thermal imaging between room temperature and cold exposure among Samoans (N = 61, females: n = 38) from 'Upolu Island, Samoa. BAT activity was inferred using ANOVA linear regression models with the variables measured at cold exposure as outcomes. T-tests were used to compare changes in surface temperature between room temperature and cold exposure. RESULTS: Metabolic rate significantly increased after cooling. In both the supraclavicular area, a known BAT location, and the sternum, a non-BAT location, temperatures decreased significantly upon cold exposure. Differences in supraclavicular temperatures between room temperature and cold were significantly smaller than differences in sternum temperatures between exposures. These results suggest that BAT thermogenesis occurred in known BAT-locations and thus contributed to NST during cooling. CONCLUSIONS: This study adds to our understanding of BAT activity across different populations and climates. Further study may illuminate whether the cold-adaptive properties of BAT may have played a role in the successful expansion of populations across the globe, including warm-climate groups.

Indication of mixed glucose and fatty acid use by inferred brown adipose tissue activity in Samoans.

OBJECTIVES: Despite the growing rates of global obesity and the known positive associations between brown adipose tissue (BAT) and cardiovascular health, little is known about the metabolic effects of BAT activity in Samoans, a population at high risk of obesity and type II diabetes. Here we assessed the potential effects of inferred BAT activity on metabolic health markers in Samoan adults exposed to mild cold. METHODS: Using point-of-care finger prick technology we measured fasting glucose, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels before and after 30 min of cold exposure among 61 individuals (38 females, 23 males, ages 31-54) from 'Upolu Island, Samoa. Respiratory quotient was measured by indirect calorimetry to determine substrate metabolism at room temperature and cold exposure. RESULTS: Fasting glucose levels decreased significantly (p < .001) after cold exposure while neither total cholesterol (p = .88), HDL (p = .312), nor LDL (p = .089) changed. Respiratory quotient decreased significantly (p = .009) between exposures, suggesting an increased preference for lipid metabolism as a response to cold. CONCLUSIONS: The observed effects of inferred BAT activity on biomarkers suggest BAT activity utilizes both glucose and lipid-derived fatty acids as fuel for thermogenesis. Our work provides evidence for the beneficial metabolic effects of BAT and emphasizes the need for the population-specific development of metabolic treatments involving BAT to ensure the successful and equitable minimization of extreme consequences of obesity and metabolic health.

Total Energy Expenditure and Nutritional Intake in Continuous Multiday Ultramarathon Events.

Continuous multiday ultramarathon competitions are increasingly popular and impose extreme energetic and nutritional demands on competitors. However, few data have been published on energy expenditure during these events. Here, we report doubly labeled water-derived measures of total energy expenditure (in kilocalories per day) and estimated physical activity level (PAL: total energy expenditure/basal metabolic rate) collected from five elite and subelite finishers (four males and one female, age 34.6 ± 4.9 years)-and nutritional intake data from the winner-of the Cocodona 250, a ∼402-km race in Arizona, and from a fastest-known-time record (one male, age 30 years) on the ∼1,315-km Arizona Trail. PAL during these events exceeded four times basal metabolic rate (Cocodona range: 4.34-6.94; Arizona Trail: 5.63). Combining the results with other doubly labeled water-derived total energy expenditure data from ultraendurance events show a strong inverse relationship between event duration and PAL (r2 = .68, p < .0001). Cocodona race duration was inversely, though not significantly, associated with PAL (r2 = .70, p = .08). Water turnover varied widely between athletes and was not explained by PAL or body mass. The Cocodona race winner met ∼53% of energy demand via dietary intake, 85.6% of which was carbohydrate, while ∼47% of energy demand was met via catabolism of body energy stores. Together, these results illustrate the energetic deficits incurred during competitive continuous multiday ultramarathon efforts and implicate macronutrient absorption and/or storage as key factors in ultramarathon performance.

To the extreme! How biological anthropology can inform exercise physiology in extreme environments.

The fields of biological anthropology and exercise physiology are closely related and can provide mutually beneficial insights into human performance. These fields often use similar methods and are both interested in how humans function, perform, and respond in extreme environments. However, these two fields have different perspectives, ask different questions, and work within different theoretical frameworks and timescales. Biological anthropologists and exercise physiologists can greatly benefit from working together when examining human adaptation, acclimatization, and athletic performance in the extremes of heat, cold, and high-altitude. Here we review the adaptations and acclimatizations in these three different extreme environments. We then examine how this work has informed and built upon exercise physiology research on human performance. Finally, we present an agenda for moving forward, hopefully, with these two fields working more closely together to produce innovative research that improves our holistic understanding of human performance capacities informed by evolutionary theory, modern human acclimatization, and the desire to produce immediate and direct benefits.

Estimated energetic demands of thermoregulation during ancient canoe passages from Tahiti to Hawaii and New Zealand, a simulation analysis.

Prehistoric colonization of East Polynesia represents the last and most extensive of human migrations into regions previously uninhabited. Although much of East Polynesia is tropical, the southern third, dominated by New Zealand-by far the largest Polynesian landmass-ranges from a warm- to cool-temperate climate with some islands extending into the Subantarctic. The substantial latitudinal variation implies questions about biocultural adaptations of tropical people to conditions in which most of their familiar resources were absent and their agriculture marginal. Perhaps the most basic question, but one which has never been explored, is the extent to which sailing out of the tropics on long-distance colonizing voyages imposed physiological stress on canoe crews and passengers. In this paper we use trajectories of simulated voyages from Tahiti to New Zealand and Tahiti to Hawaii to obtain along-trip environmental parameters which are then used to model the energy expenditure of these long overseas journeys. Results show that travelers to New Zealand are exposed to much harsher environmental conditions, leading to significantly greater in-trip thermoregulatory demands. For both destinations, travelers with larger body sizes exhibit lower modeled heat loss and hence obtain an energetic advantage, with greater gains for females. Such physiological features, notably of Samoans who probably formed the founding population in East Polynesia, may help explain successful voyaging to temperate latitudes.

The impact of winter warming and more frequent icing events on reindeer herder occupational safety, health, and wellbeing.

BACKGROUND: Northern Finland, like the rest of the Arctic, has experienced increases in mean annual temperature, the number of winter rains, the number of thaw-freeze days, the number of extremely warm weather events, and a shortened snow season. These changes have produced numerous problems for reindeer herders whose livelihoods rely on a healthy ecosystem with predictable weather patterns. METHODS: We performed a scoping literature review to assess how climate change induced extreme weather has negatively impacted reindeer herding as well as the health and wellbeing of reindeer herders. RESULTS: Late snow cover negatively impacts reindeer herding through a more widely dispersed herd that increases the work to gather reindeer, leads to reduced calf weight, and results in less meat for sale. This increased labor, especially in extreme cold conditions, can also negatively impact reindeer herder health. Icing due to thaw-freeze and rain-on-snow events makes it impossible for reindeer to dig through the snow to access lichens, increasing the need for reindeer herders to keep the herd in winter enclosures and provide supplemental feed. CONCLUSION: Climate change induced weather events such as late snow cover and icing increase reindeer herder efforts and expenses, put their livelihood at risk, and put their health at risk.

Commentary-fat but fit and cold? Potential evolutionary and environmental drivers of metabolically healthy obesity.

As global obesity rates continue to rise, it is important to understand the origin, role and range of human variation of body mass index (BMI) in assessing health and healthcare. A growing body of evidence suggests that BMI is a poor indicator of health across populations, and that there may be a metabolically healthy obese phenotype. Here, we review the reasons why BMI is an inadequate tool for assessing cardiometabolic health. We then suggest that cold climate adaptations may also render BMI an uninformative metric. Underlying evolutionary and environmental drivers may allow for heat conserving larger body sizes without necessarily increasing metabolic health risks. However, there may also be a potential mismatch between modern obesogenic environments and adaptations to cold climates, highlighting the need to further investigate the potential for metabolically healthy obese phenotypes among circumpolar and other populations as well as the broader meaning for metabolic health.

Brown adipose tissue thermogenesis among a small sample of reindeer herders from sub-Arctic Finland.

INTRODUCTION: Interest in human physiological responses to cold stress have seen a resurgence in recent years with a focus on brown adipose tissue (BAT), a mitochondria dense fat specialized for heat production. However, a majority of the work examining BAT has been conducted among temperate climate populations. METHODS: To expand our understanding of BAT thermogenesis in a cold climate population, we measured, using indirect calorimetry and thermal imaging, metabolic rate and body surface temperatures of BAT-positive and BAT-negative regions at room temperature, and mild cold exposure of resting participants from a small sample of reindeer herders (N = 22, 6 females) from sub-Arctic Finland. RESULTS: We found that most herders experienced a significant mean 8.7% increase in metabolic rates, preferentially metabolized fatty acids, and maintained relatively warmer body surface temperatures at the supraclavicular region (known BAT location) compared to the sternum, which has no associated BAT. These results indicate that the herders in this sample exhibit active BAT thermogenesis in response to mild cold exposure. CONCLUSIONS: This study adds to the rapidly growing body of work looking at the physiological and thermoregulatory significance of BAT and the important role it may play among cold stressed populations.

No association of BMI and body adiposity with cardiometabolic biomarkers among a small sample of reindeer herders of sub-Arctic Finland.

The rising global obesity rate is alarming due to its real health and socioeconomic consequences. Finland, like other circumpolar regions, is also experiencing a rise in obesity . Here we assess BMI, body adiposity, and measures of cardiometabolic health among a small population of reindeer herders in sub-Arctic Finland. We collected anthropometric and biomarker measures at two different time points: October 2018 (N = 20) and January 2019 (N = 21) with a total of 25 unique individuals across the data collection periods (ages 20-64). Anthropometric measures included height, weight, age, and body composition. Biomarkers included measures of cholesterol, fasting glucose, HDL cholesterol, LDL cholesterol, and triglyceride levels. Over 70% of this sample was classified as "overweight" and "obese" as categorised by BMI and 64% classified as "overfat" based on body fat percentage. However, there was no significant relationship between BMI and body fat percentage with any of the measured biomarkers. Although the sample size is small, the results of this study suggest there might not be a strong correlation between BMI, body adiposity, and cardiometabolic health indices within this population - a pattern that has been documented elsewhere. However, further study is needed to confirm this lack of a correlation.

Reindeer herders from subarctic Finland exhibit high total energy expenditure and low energy intake during the autumn herd roundup.

OBJECTIVE: High levels of total energy expenditure (TEE, kcal/day) have been documented among numerous human populations such as tropical climate horticulturalists and high-altitude agriculturalists. However, less work has been conducted among highly physically active cold climate populations. METHODS: In October 2018, TEE was measured using the doubly labeled water (TEEDLW , N = 10) and flex-heart rate methods (TEEHR , N = 24) for 6-14 days among reindeer herders (20-62 years) in northern Finland during an especially physically demanding, but not seasonally representative, period of the year for herders-the annual reindeer herd roundup. Self-reported dietary intake was also collected during TEE measurement periods. TEE was then compared to that of hunter gatherer, farming, and market economies. RESULTS: During the herd roundup, herders expended a mean of 4183 ± 949 kcal/day as measured by the DLW method, which was not significantly different from TEEHR . Mean caloric intake was 1718 ± 709 kcal/day, and was significantly lower than TEEDLW and TEEHR (p < .001). Herder TEEDLW was significantly higher than that of hunter gatherer (p = .0014) and market (p < .0014) economy populations; however, herder TEEDLW was not different from that of farming populations (p = .91). CONCLUSION: High TEE and low caloric intake among herders reflect the extreme demands placed on herders during the annual herd round up. Although TEEDLW was similar between cold climate herders and hot climate farming populations, there are likely differences in how that TEE is comprised, reflecting the local ecologies of these populations.

Demystifying mentorship: Tips for successfully navigating the mentor-mentee journey.

BACKGROUND: Quality mentorship is crucial for long-term success in academia and overall job satisfaction. Unfortunately, formal mentorship training is lacking, and there is little recourse for failed mentor-mentee relationships. METHODS: We performed a literature review to understand the current state of mentorship research with a focus on: (1) what mentorship is and why it is important for success; (2) establishing mentor-mentee relationships; and (3) the role of diversity, equity, and inclusion. RESULTS: From the literature review, we compiled a number of mentorship recommendations for individuals, departments, institutions, and professional associations. These recommendations focus on building a mentorship network, establishing formalized mentorship training, how to build a productive and mutually beneficial mentor-mentee relationship, and instituting a system of mentorship accountability. CONCLUSION: We hope that by centralizing this information and providing a list of resources and actionable recommendations we inspire and encourage others to make meaningful changes in their approach to mentorship to create a more kind, caring, and equitable environment in which to conduct our work.

#Hackademics: Hacks toward success in academia.

OBJECTIVE: The Sausage of Science is a podcast for the Human Biology Association and the American Journal of Human Biology through which we introduced a special series called #Hackademics. The podcast was initially used to highlight the scholarship and humanity of fellow human biologists through interviews about "how the sausage is made" in research-that is, the nuts and bolts that go into our publications. However, we soon realized there is much more a weekly podcast can do to help colleagues in our interrelated fields. METHODS: Here we introduce the different contributions to this #Hackdemics special issue. Through #Hackademics, we address under-discussed topics in academia such as work-life integration, hostile academic environments, decolonization of research and teaching, and science communication, among others. RESULTS: The feedback received from listeners for the #Hackademics series reinforced a need for more tools for navigating the academic side of our disciplines. Furthermore, there was a need to decentralize what is often termed "institutional knowledge" by sharing it in a more authoritative medium-a special issue of peer-reviewed articles in our Association's esteemed journal. This special issue's contributions also elevate diverse voices with multiple authors at different career stages. CONCLUSIONS: Using the institutional credibility of peer-review to legitimize these topics, this issue's articles can be a resource for those looking to initiate conversations or change within their departments or institutions with the hope of creating a kinder, more respectful, collaborative, equitable, and accessible academic environment.

Sex differences and shifts in body composition, physical activity, and total energy expenditure across a 3-month expedition.

OBJECTIVES: An energetically demanding environment like a wilderness expedition can lead to potent stressors on human physiology and homeostatic balance causing shifts in energy expenditure and body composition. These shifts likely have consequences on overall health and performance and may potentially differ by sex. It is therefore critical to understand the potential differential body composition and energy expenditure changes in response to a novel and challenging environment in both males and female bodies. METHODS: Data were collected from 75 healthy individuals (female = 41; ages 18-53) throughout a 3-month long expedition in the American Rockies. Body mass, body fat, and lean muscle mass were measured before, during, and after the course. Physical activity intensity and energy expenditure were also measured in a subset of participants using the wGT3X-BT Actigraph wrist monitor and an accompanying Bluetooth heart rate monitor. RESULTS: Over the 3-month period, individuals initially experienced declines in body mass, body fat percentage, and lean muscle mass. Participants partially rebounded from these deficits to maintain overall body mass with a slight recomposition of body fat and lean muscle mass. Our data also demonstrated that sex moderated total energy expenditure, where females experienced a modest decline whereas males experienced an increase in energy expenditure from the beginning to the end of the course. CONCLUSIONS: Understanding changes in energy storage in the body and variation in energy expenditure between sexes during a 3-month expedition has critical implications for maintaining health and performance in an energetically demanding environment where resources may be scarce.

Weather permitting: Increased seasonal efficiency of nonshivering thermogenesis through brown adipose tissue activation in the winter.

OBJECTIVES: We investigated seasonal changes in brown adipose tissue (BAT) activation and metabolism in a temperate-climate Albany, NY population. METHODS: Data were collected among 58 participants (21 males, 37 females, ages: 18-51) in the summer and 59 participants (23 males, 36 females, ages: 18-63) in the winter in Albany, New York. BAT activity was inferred by comparing metabolic rate, heat dissipation in the supraclavicular area, and respiratory quotient at room temperature and cold exposure. Seasonal variation in BAT was determined by comparing these measurements from summer and winter. RESULTS: At mild cold exposure, heat dissipation of the supraclavicular area was significantly greater in the winter compared to summer (p < .001); however, no significant differences were found between seasons in metabolic rate measurements. This suggests BAT activation may be metabolically more efficient in the winter, due to prolonged lower seasonal temperatures relative to summer. Respiratory quotient significantly increased upon mild cold exposure in the winter compared to summer (p < .001). While carbohydrate utilization increased in the winter, fat remained the primary metabolic substrate for BAT activity across both seasons. CONCLUSION: The seasonal variations in the effects of nonshivering thermogenesis on metabolic rate and substrate metabolism suggest a buffering of energy expenditure and an increased use of glucose as fuel by BAT as a result of acclimatization to cold in the winter. These findings point towards a potential role of BAT in human whole-body mediated glucose disposal and cold adaptation.

"I feel terrible and need to exercise to find any sort of joy": What COVID stay-at-home orders tell us about exercise as vitality politics and entertainment in the United States.

During COVID-19 stay-at-home orders (SaHOs), people faced drastic shifts in their work and home lives. These shifts, in combination with the temporary closure of gyms and fitness centers, led to exercise-routine disruption. We conducted a survey to assess how people were affected by SaHOs in terms of exercise-routine change, feelings about exercise, perceived physical and mental health, as well as exercise-routine plans once SaHOs were lifted. In this article, we examine why affluent white American women exercised before and during COVID-19 SaHOs. The article focuses on the role of pleasure and entertainment as key components of exercise practices for these women. We found that changes in motivation reveal that exercise regimens are part of contemporary vitality politics, or current cultural and subjective desires and abilities to manipulate and optimize biological human processes, that include both health and entertainment. Therefore, we argue that exercise is a meaningful cultural, entertainment, and biopolitical activity.

Feasibility of using infrared thermal imaging to examine brown adipose tissue in infants aged 18 to 25 months.

BACKGROUND: Recent studies in adults indicate that cold-induced temperature change of supraclavicular skin corresponds with brown adipose tissue (BAT) thermogenesis. AIM: This study examined the feasibility of using thermography to assess temperature changes in infants aged 18-25 months after mild cooling. Further, this study sought to evaluate whether cold exposure induces a thermal response suggestive of BAT activity underlying the supraclavicular region. SUBJECTS AND METHODS: Changes in maximum skin temperature at the supraclavicular and interscapular regions were determined using thermal imaging following a mild 5-minute cooling condition (by removal of clothes in a climate-controlled room) in 67 Samoan infants. Temperature changes of the forehead and hand, known BAT-free regions, served as indicators of cooling efficacy. RESULTS: Infants with increased hand and forehead temperatures after cold exposure were excluded from analysis, reducing the effective sample size to 19 infants. On average, forehead (p < 0.001), hand (p < 0.001) and back (0.029) temperatures dropped significantly while supraclavicular temperatures remained constant. Participants with greater decreases in forehead temperature tended to exhibit greater supraclavicular thermogenesis (p = 0.084), suggesting potential BAT activity in this region. CONCLUSIONS: While further work is necessary to develop a reliable cooling condition, this study provides proof-of-concept for non-invasive assessment of BAT activity in infants.

Between a rock and a cold place: Neanderthal biocultural cold adaptations.

A large body of work focuses on the unique aspects of Neanderthal anatomy, inferred physiology, and behavior to test the assumption that Neanderthals were hyper-adapted to living in cold environments. This research has expanded over the years to include previously unexplored and potentially adaptive features such as brown adipose tissue and fire-usage. Here we review the current state of knowledge of Neanderthal cold adaptations along morphological, physiological, and behavioral lines. While highlighting foundational as well as recent work, we also emphasize key areas for future research. Despite thriving in a variety of climates, it is well-accepted that Neanderthals appear to be the most cold-adapted of known fossil hominin groups; however, there are still many unknowns. There is a great deal yet to be uncovered about the nature and manifestation of Neanderthal adaptation and how the synergy of biology and culture helped buffer them against extreme and variable environments.