[Persistent form of bovine viral diarrhea].

The review provides an analysis of literature data on the persistent form of Bovine Viral diarrhea/Mucosal disease (BVD) and is focused on virus and host factors, including those related to immune response, that contribute the persistence of the virus. BVD is a cattle disease widespread throughout the world that causes significant economic damage to dairy and beef cattle. The disease is characterized by a variety of clinical signs, including damage to the digestive and respiratory organs, abortions, stillbirths and other failures of reproductive functions.

[Substantion of the reference Values of SCFA in saliva in ratients without upper respiratory tract diseases.]

Biochemical indicators of saliva were studied in 47 patients of the intensive care unit and intensive care unit of a neurosurgical hospital with varying degrees of severity of the disease. The method of gas-liquid chromatography of the acidified substrate of the saliva filtrate determined the concentrations of short-chain fatty acids (SCFA) and their reference values for patients without respiratory tract diseases. The threshold values of the concentrations of SCFA and the values of their calculated indices were determined by ROC analysis with the construction of the ROC curve, calculation of the area under the curve (AUC) and the cutoff threshold CutOff. The method of determining reference values of HFA in saliva developed as a result of the study makes it possible to assess the risks of developing an unfavorable course of the disease, optimize treatment tactics and improve the prognosis of the disease.

[Rationale of the method of complex treatment for localized breast cancer with the use of methodology of intraoperative radiation therapy after neoadjuvant systemic drug therapy and sentinel lymph node biopsy].

Surgery remains the primary step in the localized forms of breast cancer. To date a growing number of women in the world could be provided with organ-preserving operations (OPO). At large tumor size in relation to the volume of the breast mastectomy is needed. Neoadjuvant therapy can allow a surgeon to perform OPO. However considering the original size of tumor and the knowledge that the greatest number of local recurrences of breast cancer occur within the bed of primary tumor it is logical to settle additional radiation dose to the bed in addition to the standard external beam radiotherapy. In patients with cN- prior neoadjuvant therapy it is possible to perform sentinel lymph node biopsy in order to improve functional results.

African swine fever in the Russian Federation: spatio-temporal analysis and epidemiological overview.

African swine fever is viral disease of domestic and wild pigs which leads to almost total mortality and causes great economic losses due to absence of vaccine. Having been introduced into the Russian Federation in 2007 the disease has spread widely in the southern region of the country and since 2011 has demonstrated a tendency to form a secondary endemic zone in the central part of the country. In the present study spatio-temporal patterns of ASF diffusion in the populations of wild and domestic pigs are analyzed. The structure of the domestic swine population is conventionally divided into a sub-population at low biosecurity (77% of the total number of outbreaks in domestic pigs) and a population at high biosecurity (23%). The statistics of ASF cases registered in each of these sub-populations is presented. The possible causes of ASF diffusion across the country are discussed. The use of geo-information technologies (GIS) enabled confirmation of the conclusion that an epidemic center has shifted into the central part of Russia. The main conclusions of this study are that: (1) anthropogenic factors play the leading role in the spread of ASF across the territory of the RF; (2) small-scale private holdings (low biosecurity population) are more exposed to ASF virus introduction; (3) there is a high risk of diffusion of ASFV from the secondary endemic zone in the central part of the RF to neighboring regions.