Effects of body position on thermal, cardiorespiratory and metabolic activity in low birth weight infants.

BACKGROUND: Low birth weight (LBW) infants sleeping prone are known to exhibit many physiological differences from those sleeping supine, including lower energy expenditure (heat production) and higher surface temperature. This apparent increase in heat storage suggests that heat loss may be inhibited in the prone position which, in turn, might influence cardiorespiratory activity. AIMS: To determine the effects of body position (prone vs. supine) on absolute surface temperature profile (heat storage), central-peripheral (C-P) thermal gradients (vasomotor response), cardiorespiratory activity and metabolic gas exchange in growing LBW infants. METHODS: Six-hour continuous recordings of absolute surface temperature profiles, cardiorespiratory activity and O2 and CO2 exchange, along with minute-to-minute assessment of behavioral sleep states were performed in 32 healthy growing LBW infants (birth weight 805-1590 g, gestational age 26-35 weeks and postconceptional age at study 33-38 weeks). Each infant was randomly assigned to the prone or supine position for the first 3 h of the study and then reversed for the second 3 h. Surface temperatures were recorded from 4 sites (forehead, flank, forearm and leg) and averaged each minute. Central (forehead and flank)-to-peripheral (forearm and leg) and forehead-to-environment (H-E) thermal gradients were calculated from the surface temperatures. Corresponding sleep states were aligned with minute averages obtained from the temperature and cardiorespiratory measurements. Data were then sorted for prone and supine positions during quiet (QS) and active sleep (AS) and compared using paired t-tests. RESULTS: In the prone position during both AS and QS, infants had higher forehead, flank, forearm and leg surface temperatures, narrower C-P gradients, higher heart rates and respiratory frequency, and lower heart rate and respiratory variability. Despite similar environmental temperatures, the H-E gradient was higher in the prone position. In the prone position infants demonstrated lower O2 consumption and CO2 production and a higher respiratory quotient. CONCLUSIONS: Despite thermoregulatory adjustments in cardiorespiratory function, infants sleeping prone have relatively higher body temperature. The cardiorespiratory responses to this modest increase in temperature indicate that thermal and metabolic control of cardiac and respiratory pumps seem to work in opposition. The consequences of any attendant changes in blood gas activity (e.g. hypocapnia and/or increased mixed venous oxygen concentration) due to this override of metabolic control remains speculative.

Interactions between sleeping position and feeding on cardiorespiratory activity in preterm infants.

Infants sleeping in the prone position are at greater risk for sudden infant death syndrome (SIDS). Sleep position-dependent changes in cardiorespiratory activity may contribute to this increased risk. Cardiorespiratory activity is also affected by feeding. Twenty prematurely-born infants were studied at 31-36 weeks postconceptional age while sleeping in the prone and supine positions. Heart rate, respiratory rate, and patterns of variability were recorded during interfeed intervals, and effects of position and time after feeding were analyzed by repeated measures analyses of variance. There were significant effects of both sleeping position and time after feeding. Heart rate is higher and heart period variability is lower in the prone position, and the effects of sleeping position on cardiac functioning are more pronounced during the middle of the intrafeed interval. In preterm infants, autonomic responses to nutrient processing modulate the cardiorespiratory effects of sleeping position. Prone sleeping risk may vary with time after feeding.

Is the new definition of bronchopulmonary dysplasia more useful?

OBJECTIVE: To determine the incidence of bronchopulmonary dysplasia (BPD) in low birth weight (LBW) infants <1251 g managed with early bubble nasal continuous positive airway pressure (NCPAP) and a gentle ventilation strategy using the newly proposed definition for BPD and the previous definitions. METHODS: Needs for supplemental oxygen and positive pressure (positive pressure ventilation or NCPAP) during initial hospitalization were evaluated in 266 inborn LBW infants (birth weight <1251 g). The data were categorized in three weight groups, <751, 751 to 1000 and 1001 to 1250 g and the incidence of BPD was computed in survivors based on oxygen need at 28 days, 36 weeks postmenstrual age (PMA) and the new severity of BPD criteria, that is, mild BPD: need for supplemental oxygen > or =28 days, but not at 36 weeks PMA; moderate BPD: need for supplemental oxygen > or =28 days and <30% at 36 weeks PMA and severe BPD: need for supplemental oxygen > or =28 days, and >30% at 36 weeks PMA and/or positive pressure at 36 weeks PMA. Further, BPD-associated comorbidities and short-term outcome data during hospitalization were compared among the groups, defined by severity of BPD. RESULTS: Among LBW infants <1251 g, the incidences of BPD at 28 days and 36 weeks PMA were 21.1 and 7.4% respectively. Using the newly defined criteria, the incidences of mild, moderate and severe BPD were 13.5, 4.8 and 2.6%, respectively. In total, 64.6% of these infants had mild BPD and 70.8% weighed <751 g at birth. Associated comorbidities correlated significantly with grades of underlying pulmonary disease. Also, significantly longer hospital stay, discharge at a higher PMA and lower growth velocity was observed with increasing grades of BPD. CONCLUSIONS: The new system for grading the severity of BPD offers a better description of underlying pulmonary disease and correlates with the infant's maturity, growth and overall severity of illness. Whether it will have a role in predicting long-term outcome remains to be determined.

Quality of diet, body position, and time after feeding influence behavioral states in low birth weight infants.

The effects of variations in carbohydrate and fat intake and body position on behavioral activity states were evaluated in 64 healthy, growing low birth weight infants (birth weight, 750-1600 g). The infants, enrolled in a prospective, randomized, double-blind, controlled study of effects of quality of dietary energy, were fed one of the five formulas. These formulas contained fixed intakes of protein (4 g/kg per day) but different intakes of carbohydrate (9.1 to 20.4 g/kg per day) and fat (4.3 to 9.5 g/kg per day). Six-hour daytime sleep studies were performed at 2-wk intervals from time of full enteral intake until discharge (mean postconceptional age at first study, 33.2 +/- 1.8 wk). Infants were randomly assigned to the prone or supine position for the first 3-h postprandial period; the position was reversed during the second 3 h. Behavioral activity state, i.e. quiet sleep (QS), active sleep, indeterminate sleep, awake, or crying was coded each minute throughout the postprandial period. The overall incidence of QS was almost double in the prone position versus the supine (p < 0.0001). In contrast, the probability of being in either of the two wakeful states (awake and crying) was increased when infants were placed in supine position (p < 0.0001). Increased likelihood of being in QS while prone was found only during the 30 min after and before feeding in a 150-min prandial cycle. In contrast, increased amounts of awake and crying in supine position were observed throughout the feeding interval. As carbohydrate intake increased, time spent in QS in supine position increased (from 8.6% to 12.5%, p < 0.02), and a trend in the same direction was noted for the prone position (p = 0.06). However, during postprandial minutes 10-100, when QS is likely to be entrained by the nutrient intake, enhancement of QS was found in the prone position only (p < 0.02). Carbohydrate intake influences the total time spent and the distribution of behavioral activity states within the postprandial period in low birth weight infants. The effect of nutrient intake on sleep profile is dependent on body position and time after feed. Mechanistic hypotheses relating sudden infant death syndrome to sleeping position may need to take these observations into account.