Knowledge and Attitudes About HIV/AIDS Among Adolescent Students in 15-19 Years Age Group Based on the Adolescent Education Programme: A Cross-Sectional Study Conducted in Kamrup (Metro), Assam.

INTRODUCTION: There has been a rising trend in human immunodeficiency virus (HIV) cases globally as well as regionally. To combat the rising cases, it is very crucial to understand the perception of knowledge and attitude among the adolescent age group, as they constitute a majority of the population in India. The adolescent age group is quite vulnerable; hence, special attention has to be given to this particular age group to prevent them from acquiring high-risk behaviours. The Government of India initiated the Adolescent Education Programme to help adolescents cultivate a positive attitude and learn life skills to live a better and dignified life. Educational institutions have a significant role in imparting effective sex education to adolescents. This programme focuses on making the students aware of the dangers, stigma, and discrimination associated with HIV/acquired immunodeficiency syndrome (AIDS) as well as modes of transmission of HIV/AIDS, helping them to acquire the necessary life skills to enable them to avoid risky situations and to develop healthy and responsible behaviour. The study aims to assess the knowledge and attitude about HIV/AIDS among adolescent students aged 15-19 years and help them achieve a healthy attitude and responsible behaviour towards HIV/AIDS. METHODS: A cross-sectional study was conducted in the educational institutions of Kamrup (Metro), Assam, catering to the adolescent age group of 15-19 years for two months, beginning on March 15, 2024, and ending on May 15, 2024. Simple random sampling was done to select seven schools, and students were selected via systematic random sampling. The knowledge and attitude about HIV were assessed using a self-designed questionnaire that was pilot-tested; Cronbach's alpha was used to check the internal consistency of the questionnaire; and content validation was done by a group of four experts on the subject matter. The survey questionnaire was administered to the participants in their classrooms after obtaining prior permission from the school authorities. Fisher's exact test and Chi-square tests were done to test the associations, taking a p-value <0.05 as statistically significant. A binary logistic regression model was put up to show the influence of certain socio-demographic variables on knowledge and attitude about HIV/AIDS, taking a p-value <0.05 as statistically significant. A two-factor analysis of variance with measurement repetition was also performed. RESULTS: The majority, 165 (52.5%) of the participants, had good knowledge and attitudes regarding HIV/AIDS. The socio-demographic variables such as age, institution, grade, and religion were significantly associated with knowledge and attitude about HIV/AIDS (p-value <0.05). Regarding sources of knowledge about HIV/AIDS, the majority, 178 (56.7%) of the participants, mentioned it being taught in school or college as a part of the curriculum. CONCLUSION: It is critical to address the current lack of information and unfavourable attitudes regarding HIV/AIDS among adolescents through school-based health programmes. This should be accomplished through proactive campaigns by educators, community leaders, non-governmental organizations (NGOs), and other groups in partnership with the government.

Baseline findings of a multicentric ambispective cohort study (2021-2022) among hospitalised mucormycosis patients in India.

In India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with the COVID-19 pandemic. In response to this, we established a multicentric ambispective cohort of patients hospitalised with mucormycosis across India. In this paper, we report their baseline profile, clinical characteristics and outcomes at discharge. Patients hospitalized for mucormycosis during March-July 2021 were included. Mucormycosis was diagnosed based on mycological confirmation on direct microscopy (KOH/Calcofluor white stain), culture, histopathology, or supportive evidence from endoscopy or imaging. After consent, trained data collectors used medical records and telephonic interviews to capture data in a pre-tested structured questionnaire. At baseline, we recruited 686 patients from 26 study hospitals, of whom 72.3% were males, 78% had a prior history of diabetes, 53.2% had a history of corticosteroid treatment, and 80% were associated with COVID-19. Pain, numbness or swelling of the face were the commonest symptoms (73.3%). Liposomal Amphotericin B was the commonest drug formulation used (67.1%), and endoscopic sinus surgery was the most common surgical procedure (73.6%). At discharge, the disease was stable in 43.3%, in regression for 29.9% but 9.6% died during hospitalization. Among survivors, commonly reported disabilities included facial disfigurement (18.4%) and difficulties in chewing/swallowing (17.8%). Though the risk of mortality was only 1 in 10, the disability due to the disease was very high. This cohort study could enhance our understanding of the disease's clinical progression and help frame standard treatment guidelines.

Factors associated with unexplained sudden deaths among adults aged 18-45 years in India - A multicentric matched case-control study.

BACKGROUND OBJECTIVES: In view of anecdotal reports of sudden unexplained deaths in India's apparently healthy young adults, linking to coronavirus disease 2019 (COVID-19) infection or vaccination, we determined the factors associated with such deaths in individuals aged 18-45 years through a multicentric matched case-control study. METHODS: This study was conducted through participation of 47 tertiary care hospitals across India. Cases were apparently healthy individuals aged 18-45 years without any known co-morbidity, who suddenly (<24 h of hospitalization or seen apparently healthy 24 h before death) died of unexplained causes during 1 st October 2021-31 st March 2023. Four controls were included per case matched for age, gender and neighborhood. We interviewed/perused records to collect data on COVID-19 vaccination/infection and post-COVID-19 conditions, family history of sudden death, smoking, recreational drug use, alcohol frequency and binge drinking and vigorous-intensity physical activity two days before death/interviews. We developed regression models considering COVID-19 vaccination ≤42 days before outcome, any vaccine received anytime and vaccine doses to compute an adjusted matched odds ratio (aOR) with 95 per cent confidence interval (CI). RESULTS: Seven hundred twenty nine cases and 2916 controls were included in the analysis. Receipt of at least one dose of COVID-19 vaccine lowered the odds [aOR (95% CI)] for unexplained sudden death [0.58 (0.37, 0.92)], whereas past COVID-19 hospitalization [3.8 (1.36, 10.61)], family history of sudden death [2.53 (1.52, 4.21)], binge drinking 48 h before death/interview [5.29 (2.57, 10.89)], use of recreational drug/substance [2.92 (1.1, 7.71)] and performing vigorous-intensity physical activity 48 h before death/interview [3.7 (1.36, 10.05)] were positively associated. Two doses lowered the odds of unexplained sudden death [0.51 (0.28, 0.91)], whereas single dose did not. INTERPRETATION CONCLUSIONS: COVID-19 vaccination did not increase the risk of unexplained sudden death among young adults in India. Past COVID-19 hospitalization, family history of sudden death and certain lifestyle behaviors increased the likelihood of unexplained sudden death.