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1.
Sci Rep ; 14(1): 7296, 2024 03 27.
Artigo em Inglês | MEDLINE | ID: mdl-38538741

RESUMO

The detection of spontaneous magnetic signals can be used for the non-invasive electrophysiological evaluation of induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs). We report that deep learning with a dataset that combines magnetic signals estimated using numerical simulation and actual noise data is effective in the detection of weak biomagnetic signals. To verify the feasibility of this method, we measured artificially generated magnetic signals that mimic cellular magnetic fields using a superconducting quantum interference device and attempted peak detection using a long short-term memory network. We correctly detected 80.0% of the peaks and the method achieved superior detection performance compared with conventional methods. Next, we attempted peak detection for magnetic signals measured from mouse iPS-CMs. The number of detected peaks was consistent with the spontaneous beats counted using microscopic observation and the average peak waveform achieved good similarity with the prediction. We also observed the synchronization of peak positions between simultaneously measured field potentials and magnetic signals. Furthermore, the magnetic measurements of cell samples treated with isoproterenol showed potential for the detection of chronotropic effects. These results suggest that the proposed method is effective and has potential application in the safety assessment of regenerative medicine and drug screening.


Assuntos
Aprendizado Profundo , Células-Tronco Pluripotentes Induzidas , Animais , Camundongos , Miócitos Cardíacos , Isoproterenol/farmacologia , Avaliação Pré-Clínica de Medicamentos , Diferenciação Celular
2.
J Orthop Case Rep ; 13(7): 14-19, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37521400

RESUMO

Introduction: The purpose of treatment for Legg-Calvé-Perthes disease (LCPD) is to regain the sphericity of the femoral head in childhood and prevent degenerative changes in adulthood. Due to the largely unsatisfactory results of conservative treatment for late-onset LCPD (i.e. patient age >9 years.), surgery is generally indicated. Various surgeries have been applied and the reported short-term results are generally good. However, few reports have described the long-term (approximately 30 years) outcomes of femoral anterior rotational osteotomy (ARO). We herein report the long-term results of late-onset LCPD treated by femoral ARO. Case Report: This report describes a boy and a girl with LCPD who underwent surgical treatment at the ages of 12 and 11 years, respectively. Conservative treatment with a brace had initially been applied, but the patients subsequently developed hinge abduction; therefore, we performed femoral ARO. Five-year postoperatively, the patients' Stulberg classification was Class II and Class III, respectively. The clinical results were satisfactory after 27 years of follow-up. Slight anterior residual deformity was seen, but there were no degenerative changes. Conclusion: In patients with hinge abduction, it is difficult to achieve good containment by conservative treatment, and even by surgical treatment, degenerative changes can occur in the early post-operative period. In severe cases of late-onset LCPD, a femoral ARO is performed, effectively transferring the viable posterior area of the femoral head onto the weight-bearing area. Maintaining good sphericity of the femoral head helps to prevent degenerative change and leads good long-term results. Both patients described in this report were asymptomatic and did not show any signs of degenerative change upon final examination. We did, however, confirm that the anterior head-neck junction exhibited residual deformity. ARO is a proven effective option for treating late-onset severe LCPD.

3.
J Foot Ankle Surg ; 62(5): 820-824, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37160202

RESUMO

Congenital clubfoot is one of the most common deformities in children, and currently, the Ponseti method is used worldwide because of its favorable short-term results. With the Ponseti method, the indication for Achilles tenotomy is traditionally based on only physical examination findings; however, some surgeons have also utilized plain radiographs. Because using physical examinations to determine the degree of hindfoot dorsiflexion for the indication of tenotomy can lead to underestimation. We developed and utilized the effectiveness of the tibio-plantar fascia angle (Ti-P angle) in the lateral maximum dorsiflexion view in determining the need for Achilles tenotomy. A retrospective analysis of consecutive 26 patients with congenital idiopathic clubfeet (37 feet) was performed. Whether Achilles tenotomy was indicated was determined based on physical examination for a former period (Group P). For the latter period, whether tenotomy was indicated was determined by referencing radiographs (Group X). No significant differences were found in any of the background factors or severity between Group P and Group X. Cases with larger tibiocalcaneal and Ti-P angles were more likely to require Achilles tenotomy or additional soft tissue release. An angle of more than 72° of the Ti-P angle demonstrated adequate specificity for the indication of Achilles tenotomy. The radiographic lateral tibio-plantar fascia angle is useful for deciding whether a tenotomy needs to be performed.


Assuntos
Tendão do Calcâneo , Pé Torto Equinovaro , Criança , Humanos , Lactente , Pé Torto Equinovaro/diagnóstico por imagem , Pé Torto Equinovaro/cirurgia , Estudos Retrospectivos , Tenotomia/métodos , Moldes Cirúrgicos , Tendão do Calcâneo/diagnóstico por imagem , Tendão do Calcâneo/cirurgia , Fáscia , Resultado do Tratamento
4.
PLoS One ; 16(3): e0247886, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33684119

RESUMO

OBJECTIVES: To investigate the growth velocity-improving effects of vitamin D replacement therapy in pediatric patients diagnosed with vitamin D deficiency and insufficiency. STUDY DESIGN: A retrospective cohort study was conducted in 34 pediatric patients diagnosed with vitamin D deficiency/insufficiency. Based on the clinical findings, the subjects were divided into two groups: a bowed leg (BL) group and a non-bowed leg (non-BL) group. After the initiation of alfacalcidol, the standard deviation score (SDS) of their heights, weights and growth velocities in each group were monitored. RESULTS: The median age at the first visit was significantly lesser in the BL group (1.58 years old [interquartile range (IQR): 1.33, 2.17]) than that in the non-BL group (3.00 years old [IQR: 2.33, 3.67]). On the contrary, the SDS for height was significantly lower in the non-BL group (-2.27 [IQR: -2.63, -1.94]) than that in the BL group (-1.37 [IQR: -1.91, -1.07]). One-year treatment with alfacalcidol showed significant improvements in both height SDSs and growth velocity SDSs not only in the BL group but also in the non-BL group. CONCLUSIONS: The current study revealed that vitamin D replacement therapy improved the growth rate in children with vitamin D deficiency/insufficiency, regardless of the presence of BL. This study emphasizes the importance of assessing the vitamin D status in children with poor growth rates and suggests that alfacalcidol could be a valid option for the treatment of short stature.


Assuntos
Desenvolvimento Infantil/efeitos dos fármacos , Hidroxicolecalciferóis/administração & dosagem , Deficiência de Vitamina D/tratamento farmacológico , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Deficiência de Vitamina D/diagnóstico , Deficiência de Vitamina D/fisiopatologia
5.
Hand (N Y) ; 15(5): 722-726, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32447986

RESUMO

Background: Although cases of impaired long bone growth due to bone and joint infections in childhood are sometimes reported, few cases of growth impairment of the ulna due to septic osteomyelitis have been described. We report herein a case of ulnar partial physeal arrest treated using the Langenskiöld procedure. Materials and Methods: A boy developed septic osteomyelitis of the right distal ulna at age 2 years 6 months. Osteomyelitis subsided after antibiotic treatment and external immobilization. As a result of impaired growth of the ulna along the long axis, shortening and trumpet-shaped deformity of the metaphysis gradually appeared. Computed tomography revealed a bony bridge, and premature epiphyseal closure due to osteomyelitis was diagnosed. The Langenskiöld procedure was performed at 4 years 4 months old. Results: As of 2 years 9 months later, no further ulnar shortening has occurred and morphological remodeling has been confirmed. Conclusions: The treatments employed for ulnar shortening include ulnar lengthening by callotasis as well as stapling of the distal radial epiphyseal line or radial shortening osteotomy. In this case, the Langenskiöld procedure proved effective because the patient was still young with growth potential and the area of the bony bridge after osteomyelitis-induced epiphyseal line damage was <30%.


Assuntos
Osteogênese por Distração , Osteomielite , Pré-Escolar , Humanos , Lactente , Masculino , Osteomielite/diagnóstico por imagem , Osteomielite/etiologia , Osteomielite/cirurgia , Osteotomia , Rádio (Anatomia) , Ulna/diagnóstico por imagem , Ulna/cirurgia
6.
Strategies Trauma Limb Reconstr ; 15(3): 179-183, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-34025800

RESUMO

AIM: To describe the novel hybrid fixation technique for paediatric femoral supracondylar fracture during circular external fixation of the lower limb. BACKGROUND: The Ilizarov external fixator is commonly used for various orthopaedic conditions. Difficulties associated with external fixation have previously been described. A fall while using a circular external fixator can cause ipsilateral fracture. Such fractures are ideally treated conservatively, but it is difficult to fix the frame itself. No study has reported the treatment of paediatric femoral supracondylar fracture during circular external fixation. Herein, we describe a novel hybrid fixation technique that was successfully used to treat paediatric femoral supracondylar fracture in three paediatric patients with circular external fixators. TECHNIQUE: The fracture was manually manipulated and reduced by slight hyperextension of the lower extremity under general anaesthesia. After confirmation of good reduction, a stockinette, a cast padding, and a thin core cast were applied to the ipsilateral thigh. The hinge parts were attached to the medial and lateral sides of the proximal ring. The rods were connected to the medial and lateral hinges, and the half ring was connected to the ventral side of the proximal end. Under fluoroscopic confirmation, the thin core cast of the thigh and rods were connected by cast rolled in a figure-of-eight manner. The hinges were locked with the knee joint slightly flexed. CONCLUSION: The minimally invasive hybrid fixation technique enables conservative treatment of paediatric femoral supracondylar fracture during circular external fixation of the lower limb with no complications, and early exercise and recovery. CLINICAL SIGNIFICANCE: This novel hybrid fixation technique will be an effective method for paediatric femoral supracondylar fracture in patients with a circular external fixator. HOW TO CITE THIS ARTICLE: Oka Y, Kim W-C, Yoshida T, et al. Hybrid Fixation for Paediatric Femoral Supracondylar Fracture during Circular External Fixation of the Lower Limb. Strategies Trauma Limb Reconstr 2020;15(3):179-183.

7.
J Magn Reson Imaging ; 51(1): 133-143, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31044458

RESUMO

BACKGROUND: Growth plate injuries and disorders cause premature closure, resulting in shortened or deformed limbs. Quantitative assessment by MRI might monitor the status of the growth plate and may assist in the prediction of these deformations. PURPOSE: To investigate whether the status of the growth plate can be monitored by quantitative evaluation using MRI of the noninjured region of the growth plate in a physeal injury model. STUDY TYPE: Prospective, longitudinal. ANIMAL MODEL: A 3.0-mm drill was used to create an injury to the central region of the right proximal tibial growth plate in 5-week-old male Japanese white rabbits (N = 18). The left tibia served as the control. FIELD STRENGTH/SEQUENCE: 7.04T, T2 -weighted imaging, diffusion-weighted imaging. ASSESSMENT: Eight of 18 rabbits underwent MRI, proton density-weighted imaging, and T2 -weighted and diffusion-weighted imaging. T2 and apparent diffusion coefficient (ADC) maps were generated for each image. The growth plate height and the T2 and ADC values of the noninjured region were measured. Two rabbits were sacrificed at 2, 4, 6, 8, and 10 weeks postinjury. Proximal tibial bones were evaluated using microcomputed tomography, histological, and immunohistological methods. STATISTICAL TESTS: Data were compared using repeated-measures analysis of variance followed by Tukey post-hoc multiple comparison. RESULTS: Growth plate height decreased at 10 weeks postinjury (P = 0.018) on the injured side. T2 values were greater at 2 weeks postinjury (P = 0.0478) and decreased at 8 and 10 weeks (P = 0.0226, P = 0.0470, respectively) on the injured side. ADC values increased at 6 weeks on the lateral side (P = 0.0304) and decreased at 8 weeks and 10 weeks postinjury (P < 0.01) on the medial and injured sides, respectively. DATA CONCLUSION: Quantitative MRI can help monitor the status of the growth plate and capture its changes early. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:133-143.


Assuntos
Imageamento por Ressonância Magnética/métodos , Fraturas Salter-Harris/diagnóstico por imagem , Animais , Modelos Animais de Doenças , Lâmina de Crescimento/diagnóstico por imagem , Estudos Longitudinais , Masculino , Estudos Prospectivos , Coelhos
8.
Turk J Phys Med Rehabil ; 65(1): 9-15, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31453539

RESUMO

OBJECTIVES: This study aims to investigate the effectiveness of orthosis therapy using a medial-wedge insole (MWI) with a height of 5 mm and an arch support for children with intoeing gait who are prone to falling. PATIENTS AND METHODS: Between January 1997 and July 2014, a total of 51 children (24 males, 27 females; mean age 5.0 years; range, 3 to 8 years) who were treated for an intoeing gait symptom of easily falling using the MWI (toe-in gait group) were included. The effectiveness of the MWI was evaluated based on the scores reported by children and their parents on a scale. Physical findings of the study group were also compared with a control group consisting of seven healthy children (4 males, 3 females; mean age 5.2 years; range, 3 to 6.2 years). Foot stability with and without MWI were assessed. RESULTS: The MWI was found to be effective in 80.8% of the toe-in gait group. Bilateral sum of the internal rotation angle of the hip (IRAB) was significantly higher (136±17°) (p=0.007) and bilateral sum of thigh foot angle (TFAB) significantly lower (-27±21°) (p<0.001) before using MWI in the toe-in gait group, compared to the control group. The maximum range of motion of the foot in six children in the toe-in gait group significantly decreased from 14.1±5.0° without MWI to 8.2±3.0° with MWI (p=0.002) in the gait analysis. CONCLUSION: These study results suggest that MWI is effective in reducing the risk of falling in children with intoeing gait, mainly due to the internal torsion of the tibia or femur. In addition, it appears to be effective in improving the maximum range of motion of the foot.

10.
BMC Cancer ; 18(1): 503, 2018 05 02.
Artigo em Inglês | MEDLINE | ID: mdl-29716532

RESUMO

BACKGROUND: Ewing's sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing's sarcoma at the distal end of the tibia. Reconstruction after wide resection is especially difficult in children, as it is necessary to consider the growth and activity of the lower limbs. CASE PRESENTATION: A 12-year-old Japanese boy had presented with right lower leg pain at age 8 years. Imaging examination showed a bone tumor accompanied by a large extra-skeletal mass in the distal part of his tibia. The tumor was histologically diagnosed as Ewing's sarcoma. The patient received chemotherapy, followed by wide resection. Reconstruction consisted of a bone transport method involving external fixation of Taylor Spatial Frame. To prevent infection after surgery, the external fixation pin was coated with iodine. One year after surgery, the patient showed poor consolidation of bone, so iliac bone transplantation was performed on the extended bones and docking site of the distal tibia. After 20 months, tibia formation was good. Three years after surgery, there was no evidence of tumor recurrence or metastases; bone fusion was good, and he was able to run. CONCLUSIONS: The bone transport method is an effective surgical method of reconstruction after wide resection of a bone tumor at the distal end of the tibia, if a pin can be inserted into the distal bone fragment. Coating external fixation pins with iodine may prevent postoperative infection.


Assuntos
Tratamentos com Preservação do Órgão , Sarcoma de Ewing/cirurgia , Tíbia/patologia , Tíbia/cirurgia , Transplante Ósseo , Criança , Extremidades , Humanos , Imageamento por Ressonância Magnética , Masculino , Radiografia , Sarcoma de Ewing/diagnóstico , Fatores de Tempo , Resultado do Tratamento
11.
Orthopedics ; 41(1): 54-58, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-29257188

RESUMO

Evaluation of callus maturation and the decision to remove an external fixator depend on radiographic and clinical findings, which are subjective. Callus fracture or recurrent deformity may occur after premature removal of a fixator. The authors applied a technique to measure bioelectrical impedance to assess callus maturation. This study included 27 limbs that underwent deformity correction or callus distraction using a fixator. Mean patient age at the time of surgery was 17.2 years. Overall impedance during callus maturation was measured from after completion of correction or distraction to removal of the fixator. Temporal changes in impedance values were measured, and maximum and final values were compared with initial values. The resistance rates were compared by age (<15 or ≥15 years), correction site (femur or tibia), and treatment method (noncontact or contact). Mean overall impedance increased gradually. Compared with initial values, maximum and final impedance values were 1.21 times and 1.15 times higher, respectively. Resistance rates by age, correction site, and treatment method were significantly higher in patients 15 years and older, in the tibia, and in the contact group, respectively. Overall impedance tended to increase during callus maturation but varied among patients. Therefore, resistance rates were calculated to classify differences for individual patients. Age and treatment method were important predictors of resistance rates. These data by age, correction site, and treatment method, which assume overall impedance from after completion of correction or distraction, can serve as a useful index to determine when a fixator should be removed. [Orthopedics. 2018; 41(1):54-58.].


Assuntos
Calo Ósseo/fisiologia , Fixadores Externos , Fêmur/cirurgia , Fixação de Fratura , Fraturas Ósseas/cirurgia , Tíbia/cirurgia , Adolescente , Adulto , Calosidades , Criança , Impedância Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteogênese por Distração , Adulto Jovem
12.
J Orthop ; 14(4): 515-519, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28860685

RESUMO

Multiple epiphyseal dysplasia (MED) may be complicated by osteochondritis dissecans (OCD), most commonly reported in the knee, but involvement of the elbow is very rare. Optimal treatment for MED-associated elbow OCD and treatment outcome have not been established. This report describes the case of an adolescent male patient with elbow OCD treated by arthroscopic drilling at a previous clinic. Progression of osteoarthritis and radial head subluxation were observed. Resection of the osteophytes and modified wedge osteotomy of the lateral condyle were then performed, and a favorable result was obtained by decompression and sufficient congruency of the radiohumeral joint.

13.
Case Rep Orthop ; 2017: 8981250, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28154765

RESUMO

Slipped capital femoral epiphysis (SCFE) is a common disease of adolescent and the epiphysis is positioned more posteromedially in relation to the femoral neck shaft with varus SCFE; however, posterolateral displacement of the capital epiphysis, valgus SCFE, occurs less frequently. We report a case of valgus SCFE in a 17-year-old boy with hypopituitarism. After falling down, he experienced difficulty in walking. The radiographs were inconclusive; however three-dimensional computed tomography images showed lateral displacement of the epiphysis on the right femoral head. Valgus SCFE was diagnosed. The patient underwent in situ pinning of both sides. In situ pinning on the left side was performed as a prophylactic pinning because of endocrine abnormalities. At the 1-year follow-up, he could walk without any difficulty and there were no signs of pain. The epiphysis is commonly positioned more posteromedially in relation to the femoral neck shaft with most SCFE, but, in this case, the epiphysis slipped laterally. Differential diagnosis included femoral neck fracture (Delbet-Colonna type 1); however, this was less likely due to the absence of other clinical signs. Therefore, we diagnosed the patient as SCFE. When children complain of leg pain and limp, valgus SCFE that may not be visualized on anteroposterior radiographs needs to be considered.

14.
J Foot Ankle Surg ; 56(2): 298-303, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28117255

RESUMO

Pedography provides excellent visualization of the footprint. However, the correlation between the footprint images and radiographic measures has not been thoroughly evaluated. Therefore, the objectives of our study were to examine the correlation between the pedography-based measures of foot morphology and radiographic measurements and to propose reference values for the diagnosis of flatfoot using footprint imaging. The plantar footprints of 100 right feet were photographed using a pedography standing platform. The sole and arch areas were measured to calculate the footprint index (FPI). The lateral talar-first metatarsal angle (LTM) and calcaneal pitch angle (CP) were measured on standing lateral radiographs, and the talonavicular coverage angle was measured on frontal radiographs. The Pearson moment correlation between the FPI and radiography-based measures was calculated. The area under the receiver operating characteristic curve was calculated using an LTM of <-4° as the identifying criterion of flatfoot. The sensitivity and specificity of FPI were calculated for LTM values <-4°. The FPI correlated with the LTM (y = -17.964 ± 52.644x, R = 0.588) and CP (y = 9.2304 ± 27.739x, R = 0.659) but not with the talonavicular coverage angle (y = 26.01 ± 15.78x, R = 0.207). The area under the receiver operating characteristic curve was 0.753, with a cutoff FPI of 0.208, yielding a sensitivity of 0.462 and specificity of 0.934 for flatfoot identification. Pedography could provide an easy screening tool for flatfoot, with an FPI cutoff of 0.208, yielding a specificity of 93.4%.


Assuntos
Pé Chato/diagnóstico , Pé/anatomia & histologia , Pé/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Antropometria , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia , Valores de Referência , Sensibilidade e Especificidade , Adulto Jovem
15.
J Orthop ; 13(4): 410-3, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27621557

RESUMO

OBJECTIVE: This study aimed to assess acetabular anteversion angle (AAA) from the early stage of Perthes disease to adolescence. METHODS: Twenty-five patients treated conservatively were examined. Changes in AAA from initial to final measurement were compared between the two groups (G-group: Stulberg classes I and II; P-group: classes III and IV). RESULTS: In the G-group, AAA decreased significantly in the affected hip compared with the unaffected hip, whereas AAA decreased in both hips in the P-group. CONCLUSION: Acetabular retroversion may occur only in the affected hip or in both hips; in the latter case, the treatment outcome may be poor.

16.
Clin Cases Miner Bone Metab ; 13(1): 19-24, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27252738

RESUMO

BACKGROUND: The incidence of femoral neck and trochanteric fractures reportedly differ by age and regionality. We investigated differences in monthly variations of the occurrence of femoral neck and trochanteric fractures as well as place and cause of injury in the Kyoto prefecture over a 6-year period. METHODS: Fracture type (neck or trochanteric fracture), age, sex, place of injury, and cause of injury were surveyed among patients aged ≥ 65 years with hip fractures that occurred between 2008 and 2013 who were treated in 1 of 13 participating hospitals (5 in an urban area and 8 in a rural area). The proportion of sick beds in the participating hospitals was 24.7% (4,151/16,781). Monthly variations in the number of patients were investigated in urban and rural areas in addition to the entire Kyoto prefecture. Place of injury was classified as indoors or outdoors, and cause of injury was categorized as simple fall, accident, or uncertain. RESULTS: There were 2,826 patients with neck fractures (mean age, 82.1 years) and 3,305 patients with trochanteric fractures (mean age, 85.0 years). There were similarities in the monthly variation of the number of fractures in addition to the place and cause of injury between neck and trochanteric fractures. Indoors (approximately 74%) and simple falls (approximately 78%) were the primary place and cause of injury, respectively. The place of injury was not significantly different by fracture type with each age group. Significantly more patients with neck fracture had "uncertain" as the cause of injury than trochanteric fracture in all age groups. CONCLUSIONS: Based on the results of the present study, the injury pattern might not have a great effect on the susceptibility difference between neck and trochanteric fractures.

17.
J Pediatr Orthop B ; 24(6): 493-506, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26163864

RESUMO

Lateral subluxation of the femoral head is one of the poor prognostic factors of Legg-Calvé-Perthes disease. The aim of this study was to investigate the cause of lateral subluxation of the femoral head on the basis of the changes over time on MRI. Twenty-four patients with unilateral Legg-Calvé-Perthes disease were analyzed retrospectively. Lateral subluxation was measured as the tear drop distance on radiographs. We focused on joint fluid, medial articular cartilage thickening, and abnormal lesion on MRI. Lateral subluxation continued significantly in patients with poor results. Among the MRI findings, the presence of an abnormal lesion was associated significantly with the continuous lateral subluxation.


Assuntos
Artrografia/métodos , Luxação do Quadril/diagnóstico , Doença de Legg-Calve-Perthes/diagnóstico , Imageamento por Ressonância Magnética/métodos , Criança , Pré-Escolar , Feminino , Cabeça do Fêmur/diagnóstico por imagem , Cabeça do Fêmur/patologia , Seguimentos , Luxação do Quadril/etiologia , Humanos , Doença de Legg-Calve-Perthes/complicações , Masculino , Estudos Retrospectivos , Fatores de Tempo
18.
J Magn Reson Imaging ; 42(6): 1698-704, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26174481

RESUMO

BACKGROUND: To elucidate the association between growth plate injury size and the beginning of physeal growth disturbance by MRI. METHODS: Thirty-two 5-week-old male Japanese white rabbits were used. Injuries were made to the right tibial proximal growth plate central region with a 3.0-mm and a 1.2-mm drill. The left tibia was used as a control. MRI (7.04 Tesla [T], gradient echo: repetition time [TR], 71.68 ms; echo time [TE], 3.60 ms; proton-density weighted imaging: TR, 2000 ms; TE, 12 ms) of the growth plates was performed at 1, 4, 8, 10, and 12 weeks postinjury. Tibia length, histology, radiography, and microcomputed tomography (µCT) were studied. RESULTS: MRI showed that at 10 and 12 weeks postinjury in the 3.0-mm group, the medial and lateral growth plates in the noninjured regions were significantly reduced compared with the controls (P < 0.05). At 12 weeks postinjury in the 1.2-mm group, medial and lateral growth plates in the noninjured regions were significantly reduced (P < 0.05). Tibia length and histological growth plate height of injured side in both groups were significantly shorter than controls at 12 weeks postinjury (P < 0.05). Comparison with the controls showed no significant difference at any of the time periods in either the 3.0- or 1.2-mm group according to the radiographic studies (P > 0.05). Bony bridges developed in all the subjects of the 3.0-mm group and in five of eight subjects of the 1.2-mm group, as shown by µCT images. CONCLUSION: This study suggested that growth plate injury size was associated with the timing of the beginning of physeal growth disturbance.


Assuntos
Lâmina de Crescimento/patologia , Imageamento por Ressonância Magnética/métodos , Fraturas Salter-Harris , Fraturas da Tíbia/patologia , Índices de Gravidade do Trauma , Animais , Diagnóstico Diferencial , Diagnóstico Precoce , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Prognóstico , Coelhos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
19.
Leg Med (Tokyo) ; 17(6): 560-8, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26162996

RESUMO

Estimation of age at death is an important part of physical and forensic anthropology. The aim of this study was to investigate whether bioelectrical impedance analysis (BIA) of long bones can be used in the field of forensic medicine as a method to estimate age at death. BIA is easy to use and allows repeat measurements to be taken over time, and the equipment is inexpensive and portable. Impedance values (Z values) in 378 long bones (humeri, radii, femora, tibiae) of 40 male (233 bones) and 26 female (145 bones) autopsy cadavers were measured using two wire electrodes (connected to an alternating current device and a measuring device) inserted into the metaphyses of long bones. Computed tomography of the greater trochanter of the femur was also analyzed to evaluate bone mineral density (BMD). The results showed that Z values could be used to estimate age in males, and with an age cut-off point of 50 years in females. When estimating age at death from femur and tibia in males by using BIA, it is not necessary to consider the length of subjects. And it was thought that Z values reflected BMD. Among the long bones, the tibia is the most suitable and easy to use for Z value measurement. Z value measurement is a useful method for quantitative evaluation of age at death that can be performed quickly with inexpensive, portable equipment.


Assuntos
Determinação da Idade pelo Esqueleto , Densidade Óssea , Impedância Elétrica , Adulto , Determinação da Idade pelo Esqueleto/instrumentação , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Antropologia Forense/métodos , Medicina Legal , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
20.
Orthopedics ; 34(10): e659-63, 2011 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-21956062

RESUMO

Prior to 1992, our postoperative management for congenital muscular torticollis consisted of either plaster cast immobilization or no immobilization, depending on the patient's age and the degree of contracture. However, some patients required further surgery and developed complications. In 1992, we produced rugby helmet braces for postoperative management. The purpose of this study was to compare the clinical results of the previous postoperative management with the results achieved using rugby helmet braces. Twenty-five children aged younger than 6 years underwent caudal partial resection of the sternocleidomastoid muscle. Twelve children aged 6 years and older underwent cranial tenotomy. These 37 patients were divided into 2 groups: no immobilization or plaster immobilization (group A; n=19) and rugby helmet braces (group B; n=18). Canale's method was used for evaluation of clinical results. In group A, the results were good in 12 patients, fair in 4, and poor in 3, whereas all 18 patients in group B had good results. Two patients in group A required further surgery, and complications were observed in 5 patients. In group B, alopecia areata was observed in 1 patient.The rugby helmet brace is easy to put on and remove, providing good retention and allowing for physiotherapy. It provides a useful method of postoperative management for congenital muscular torticollis.


Assuntos
Contratura/cirurgia , Equipamentos de Proteção , Restrição Física/métodos , Torcicolo/congênito , Torcicolo/terapia , Adolescente , Braquetes , Moldes Cirúrgicos , Criança , Pré-Escolar , Contratura/fisiopatologia , Feminino , Humanos , Lactente , Masculino , Complicações Pós-Operatórias , Período Pós-Operatório , Recuperação de Função Fisiológica , Reoperação , Restrição Física/instrumentação , Equipamentos Esportivos , Tendões/cirurgia , Tenotomia , Resultado do Tratamento
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