RESUMO
AIMS: This study examined the long-term effects of nitrous oxide anaesthesia on serum levels of cobalamin and folate, red cell folate levels and haematological parameters, and neurological status in elderly Omani patients. METHODS: Sixty-nine consecutive patients undergoing ophthalmic surgery were randomly and double-blind assigned to nitrous oxide or propofol anaesthesia. They met the following entry criteria: age 55 years or above, no major organ failure, no clinical signs or symptoms of cobalamin or folate deficiency, mean cell volume (MCV) = 96 fl, haematocrit (Hct) higher than 0.3 and no cobalamin and/or folate substitution therapy during the preceding months. Serum levels of cobalamin and folate, red cell folate levels, and haematological parameters were measured prior to anaesthesia and 3-5 weeks later. At that time, the patients also underwent thorough neurological examination. RESULTS: Data of 51 patients were complete and considered for analysis. In both nitrous oxide and propofol group, the range of exposure time was comparable (+/-1 h). In the nitrous oxide group, a slight but significant decrease in haemoglobin, Hct, and red blood cell count (RBC) (P < 0.001) was observed, whereas there was a mild increase in mean cell haemoglobin (MCH) and mean cell volume (P < 0.05). In addition, there was a significant decrease in serum folate levels (P < 0.05). Hct and RBC decreased slightly in the propofol group (P < 0. 05), whereas there was a small increase in MCH. There was no difference between the two anaesthetics with regard to serum cobalamin and red cell folate levels, but there was a significant decrease in serum folate levels in the nitrous oxide group compared to those in the propofol group. Three patients with pre-existing low red cell folate levels, who were randomized to nitrous oxide anaesthesia, developed clinical symptoms of folate deficiency. CONCLUSION: This study showed that short-term (40-80 min) nitrous oxide anaesthesia did not affect cobalamin levels but reduced serum folate levels in this elderly population. Although this reduction was clinically irrelevant, some patients with pre-existing asymptomatic folate deficiency developed nitrous oxide-induced folate deficiency.
Assuntos
Envelhecimento/fisiologia , Anestésicos Inalatórios/efeitos adversos , Ácido Fólico/sangue , Óxido Nitroso/efeitos adversos , Vitamina B 12/sangue , Idoso , Anestésicos Inalatórios/administração & dosagem , Método Duplo-Cego , Feminino , Hemoglobinas/análise , Humanos , Masculino , Pessoa de Meia-Idade , Óxido Nitroso/administração & dosagem , Procedimentos Cirúrgicos OftalmológicosAssuntos
Deficiência de Ácido Fólico/complicações , Deficiência de Ácido Fólico/diagnóstico , Doenças do Sistema Nervoso/etiologia , Idoso , Feminino , Deficiência de Ácido Fólico/sangue , Deficiência de Ácido Fólico/epidemiologia , Humanos , Incidência , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Omã/epidemiologiaRESUMO
We developed a prospective clinical study to determine the effectiveness of a new method of retrobulbar anesthesia and akinesia of the levator and orbicularis muscles. This study involved 50 patients who underwent extracapsular cataract extractions (ECCE) with intraocular lens implant (IOL). We found levator and orbicularis muscle akinesia was achieved in 49 of 50 eyes. One reblock was necessary. We also wish to point out the advantages of this technique as a means of reducing the rare but serious complications associated with retrobulbar anesthesia.
Assuntos
Anestesia/métodos , Doenças Palpebrais/cirurgia , Oftalmoplegia/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Olho , Humanos , Pressão Intraocular , Lentes Intraoculares , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
We present the early results in a small series of 12 eyes of 12 patients with uncontrolled glaucoma who underwent trabeculectomy with implantation of a Mendez Glaucoma Seton. All eyes, except one with neovascular glaucoma, had had multiple glaucoma surgery and all, without exception, were on maximal tolerated medical therapy prior to surgery. The follow-up period ranged from one and one fourth to three and three fourths months. The surgical technique was the same in all cases. Our success rate was 33.3% or 40%, if one eye with persistent hypotonia could be counted as a success. This result is inferior to those quoted in the literature with the use of other types of setons, and especially to the results of Dr. Antonio Mendez who used a similar implant.