[Long-term results of the program for preventing ischemic heart disease in Moscow (10-year follow-up study)]. / Otdalennye rezultaty provedeniia programmy mnogofaktornoi profilaktiki ishemicheskoi bolezni serdtsa v Moskve (10-letnee nabliudenie).

The paper provides the results obtained from implementation of the programme on multifactorial prevention of coronary heart disease (CHD) in Moscow, which provided strong evidence for a reduction in the levels of major risk factors and mortality from cardiovascular diseases, including coronary heart disease. The efficiency of comprehensive prophylactic measures in persons with clinical signs of CHD showed up at year 3 of their implementation and retains in subsequent years. At the same time in persons without CHD signs a mortality reduction starting at years 4-5 of the follow-up virtually came to an end when a further active intervention ceased. The impact of aftereffect of active prophylactic measures after intervention cessation turned out to be different in the examinees at various baseline risk factor levels, which suggests that continuous prophylaxis should be done, on the one hand, and it requires a differential approach, on the other. The reduction in the extent and mean levels of major risk factors, which had been achieved during a 5-year prophylactic intervention, retained, though it was less pronounced and 10 years later. However, this was followed by an increase in the mortality from myocardial infarction and stroke and their incidence in the population that had undergone active prophylactic measures, though the value of these parameters was lower at the end of the tenth year than in the controls.

[Impact of exercise on alimentary hyperlipoproteinemia in patients with ischemic heart disease]. / Vliianie fizicheskikh nagruzok na alimentarnyiu giperlipoproteidemiiu u bolnykh ishemicheskoi bolezníu serdtsa.

The impact of graded exercises of various intensity and duration on serum lipoprotein values was examined in 20 patients with coronary heart disease (CHD) and 10 healthy individuals after a single dietary fat load (FL). FL resulted in hypertriglyceridemia which was accompanied by elevated apo-AI levels and reduced apo-B/apo-AI ratio in the healthy persons, whereas it was accompanied by lower apo-AI levels and increased apo-B/apo-AI ratio in the patients. The short-term maximum exercise in the presence of FL caused negative shifts in the lipid transport system both in the healthy persons and the patients, by elevating the level of apo-B-containing lipoproteins. Yet, the healthy individuals showed a further increase in apo-AI concentrations. The long-term exercise in the training mode corrected changes in lipid values, which had been induced by FL in the two groups of the examinees. There was a decrease in the levels of triglycerides, low density lipoprotein, cholesterol and an increase in the level of high density lipoprotein cholesterol.

Ischaemic heart disease in men of productive age: comparison of epidemiological and morphological data.

Data obtained from a cross-sectional population study of men aged 20-54 years and results of a morphological epidemiological examination of the aorta and coronary arteries of 507 men aged 20-59 years, deceased from various causes in the city of Tallinn, were analysed to find whether there is a relationship between the prevalence of ischaemic heart disease (IHD), its risk factors and morphological features of atherosclerosis. An association has been found between the development of clinical IHD manifestations with age, extent of morphological signs of atherosclerosis in the abdominal aorta and coronary arteries, and occurrence of hypercholesterolaemia. Estonian men showed more marked changes in lipid indicators and greater extent of morphological signs of atherosclerosis than men of other nationalities; this corresponds to the more atherogenic character of the former's diet. However, Estonian men did not differ from other nationalities in the occurrence of IHD and expected death risk--a finding the authors explain by the lower percentage of smokers among Estonians.

Characteristics of the blood serum lipoprotein pattern in female Tallinn residents aged 35-54 years.

In a single study of the female population aged 35-54 years in the city of Tallinn no significant differences in the blood lipoprotein pattern for the nationality (Estonian--Russian) and the phase of menstrual cycle in women with normal ovarian function were found. On the other hand, in comparison with those with a normal menstrual cycle postmenopausal women showed significantly higher levels of total cholesterol, triacylglycerols and low density lipoprotein cholesterol. For studies of risk factor prevalence of non-communicable diseases among female population, it is recommended, to identify women with menstrual cycle disturbance since their higher percentages could bias the results.