A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders.

BACKGROUND: The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological infections, diseases, and their associated complications. CBD has demonstrated anti-inflammatory and curative effects in neuropathological conditions, and it exhibits therapeutic, apoptotic, anxiolytic, and neuroprotective properties. However, more information on the reactions and ability of CBD to alleviate brain-related disorders and the neuroinflammation that accompanies them is needed. MAIN BODY: This narrative review deliberates on the therapeutic and remedial prospects of CBD with an emphasis on neurological and neuropsychiatric disorders. An extensive literature search followed several scoping searches on available online databases such as PubMed, Web of Science, and Scopus with the main keywords: CBD, pro-inflammatory cytokines, and cannabinoids. After a purposive screening of the retrieved papers, 170 (41%) of the articles (published in English) aligned with the objective of this study and retained for inclusion. CONCLUSION: CBD is an antagonist against pro-inflammatory cytokines and the cytokine storm associated with neurological infections/disorders. CBD regulates adenosine/oxidative stress and aids the downregulation of TNF-α, restoration of BDNF mRNA expression, and recovery of serotonin levels. Thus, CBD is involved in immune suppression and anti-inflammation. Understanding the metabolites associated with response to CBD is imperative to understand the phenotype. We propose that metabolomics will be the next scientific frontier that will reveal novel information on CBD's therapeutic tendencies in neurological/neuropsychiatric disorders.

Corrigendum: Fusarium verticillioides of maize plant: Potentials of propitious phytomicrobiome as biocontrol agents.

[This corrects the article DOI: 10.3389/ffunb.2023.1095765.].

Fusarium verticillioides of maize plant: Potentials of propitious phytomicrobiome as biocontrol agents.

Disease outbreaks have been recorded due to exposure to Fusarium verticillioides and fumonisin, a mycotoxin produced by this fungus. F. verticillioides is a fungal pathogen of maize that causes infections, such as wilting and rotting, while contact with its fumonisin derivative manifests in the form of mild to severe illnesses in humans and animals. Maize infection by F. verticillioides causes loss or reduction in expected crop yield, thereby influencing households and nations' economies. While several efforts have been made to control the pathogenic fungus and its occurrence in the environment, it remains a challenge in agriculture, particularly in maize production. Several microorganisms which are plant-associated, especially those associated with the rhizosphere niche have been noted to possess antagonistic effects against F. verticillioides. They can inhibit the pathogen and tackle its debilitating effects on plants. Hence this study reviews the use of rhizosphere-associated biocontrol agents, such as Bacillus spp., Pseudomonas, Enterobacter, and Microbacterium oleivorans which forms part of the phytomicrobiome in other to prevent and control this toxicogenic fungus. These microorganisms were found to not only be effective in controlling its occurrence on maize plants but are environmentally safe and promote crop yield.

Survey of Maize Rhizosphere Microbiome Using Shotgun Metagenomics.

Several processes which occur in the rhizosphere make it a vital region in plant development. However, studies that examine rhizosphere microbiomes and their functional potentials remain scarce. Shotgun metagenomics was employed here to evaluate the functional potentials of the maize rhizosphere microbiome of farms in two South African provinces.

Dataset on the toxic effects of aflatoxin and ochratoxin a on the human gastric smooth muscle cells.

This dataset determined the effects of aflatoxins (B1, B2, G1 and G2) and Ochratoxin A extracted from ginger collected purposively from different retails in Mafikeng, North West province of South Africa, on the Human Gastric Smooth Muscle Cells. Hundred samples of ginger were collected and utilized for this purpose and the above mentioned toxins were extracted from the ginger, screened for on ELISA, quantified by HPLC and were exposed to the cells both individually and in combination (i.e aflatoxin and ochratoxin were combined) at different concentrations (high, moderate and low) using the human interferon beta kit. They were incubated for 12 h after which the level/concentration of human interferon produced was analyzed using the ELISA.

Comparative study of aflatoxin contamination of winter and summer ginger from the North West Province of South Africa.

The presence of mycotoxins in staple food can have adverse effect that result in ill health and associated socio-economic losses. Mycotoxins are naturally occurring toxins produced by certain fungi and can be found in staple food plants such as ginger. Ginger is a renowned medicinal plant that is extensively used for cooking and healing. However, this medicinal plant is with little information about its possible mycotoxins contamination. This study determined the occurrence and prevalence of Aflatoxin B1, B2, G1 and G2 and Ochratoxin A contamination in raw ginger sold around Mahikeng, North West Province, South Africa. Samples were collected purposively from various retailers over winter and summer. The analytical procedure optimized was based on immunoaffinity column cleanup (IAC), followed by High performance liquid chromatography with fluorescence (HPLC-FLC) detection. ELISA was also used for mycotoxin screening. On HPLC, the limits of detection and quantification for the four Aflatoxins were 3.9 × 10-7-1.4 × 10 -3 and 1.3 × 10-6 - 4.7 × 10-3 for samples collected in winter, and 3.7 × 10-7- 1.4 × 10-3, LOQ 1.2 × 10-6 - 4.6 × 10-3 for the summer samples. The average recoveries at three spiking levels ranged from 62 to 91% for the summer samples and 70-93% for those collected in winter. A linearity was observed for the analytes whose correlation coefficients were within the range of 0.9995 and 1.000 for the winter samples and 0.9995 and 1.000 for those collected in summer. The results showed that the contamination levels, especially for samples collected in summer were greater than the legally permissible limits. The t-test analysis shows that the mean and standard deviation of the four types of Aflatoxins considered were higher in summer than in winter. The findings of the study indicated that ginger, as for all agricultural commodities, are prone to mycotoxin contamination.

Prevalence of Mycotoxins and Their Consequences on Human Health.

Mycotoxin contamination is a global phenomenon and causes a wide array of negative effects and other complications. This study focused on commonly found mycotoxins in Africa and the possible means of prevention or reduction of their contaminating effects. Mycotoxins are secondary metabolites of mold and fungi; they are generally toxic to living organisms. Hundreds of mycotoxins have been identified thus far, with some, such as aflatoxins, ochratoxins, trichothecenes, zearalenone, fumonisins, and patulin, considered agro-economically important. Several factors contribute to the presence of mycotoxins in food, such as climatic conditions, pest infestation, and poor harvest and storage practices. Exposure to mycotoxins, which occurs mostly by ingestion, leads to various diseases, such as mycotoxicoses and mycoses that may eventually result in death. In light of this, this review of relevant literature focuses on mycotoxin contamination, as well as various methods for the prevention and control of their prevalence, to avert its debilitating consequences on human health. Clear evidence of mycotoxin contamination is present in Africa, and it was therefore recommended that adequate prevention and control of these toxic substances in our food system should be encouraged and that appropriate measures must be taken to ensure food safety as well as the enhanced or long-lifespan of the African populace. Governments, research institutions, and non-governmental organizations should tailor the limited resources available to tackle mycotoxin prevalence, as these will offer the best prospects for successful development of a sustainable food system in Africa.