After-training emotional interference may modulate sequence awareness in a serial reaction time task.

The purpose of the present experiment was to investigate the effects of emotional interference on consolidation of sequential learning. In different sessions, 6 groups of subjects were initially trained on a serial reaction time task (SRTT). To modulate consolidation of the newly learned skill, subjects were exposed, after the training, to 1 of 3 (positive, negative or neutral) different classes of emotional stimuli which consisted of a set of emotional pictures combined with congruent emotional musical pieces or neutral sound. Emotional intervention for each subject group was done in 2 different time intervals (either directly after the training session or 6 h later). After a 72 h post-training interval, each group was retested on the SRTT. Re-test performance was evaluated in terms of response times and accuracy during execution of a target sequence. Emotional intervention did not influence either response times or accuracy of re-testing SRTT target task performance, both variables sensitive to implicit knowledge acquired during SRTT training. However, explicit awareness of sequence knowledge after 72 h was enhanced when negative stimuli had been applied at 0 h after training. These findings suggest that consolidation of explicit aspects of procedural learning may be more responsive toward emotional interference than implicit aspects.

The motor side of emotions: investigating the relationship between hemispheres, motor reactions and emotional stimuli.

The aim of the present study was to analyze if the left hemisphere preferentially controls flexion responses toward positive stimuli, while the right hemisphere is specialized toward extensor responses to negative pictures. To this end, right-handed subjects had to pull or push a joystick subsequent to seeing a positive or a negative stimulus in their left or right hemifield. Flexion responses were faster for positive stimuli, while negative stimuli were associated with faster extensions responses. Overall, performance was fastest when emotional stimuli were presented to the left visual hemifield. This right hemisphere superiority was especially clear for negative stimuli, while reaction times toward positive pictures showed no hemispheric difference. We did not find any interaction between hemifield and response type. Neither was there a triple interaction between valence, hemifield and response type. We suppose that response dichotomies in humans are not as tightly linked to a hemisphere- and valence-bound reaction type as previously assumed.

Impairment of the rubber hand illusion in focal hand dystonia.

Patients with dystonia display a number of disturbances in the cognitive processing of movements, such as movement simulation and prediction, but whether these deficits point to a deeper rooted disturbance of perceptual bodily representations remains unknown. A useful way to investigate the sense of body ownership is the rubber hand paradigm, in which an illusion of ownership is established by synchronous stroking of the participants' real unseen hand and a visible fake hand, whereas similar asynchronous stroking does not bring about the illusion. This paradigm allows testing of both the subjective experience of feeling ownership over the rubber hand and the proprioceptive relocation of the real unseen hand towards the viewed rubber hand. Previous studies have mapped these different aspects onto two anatomically distinct neuronal substrates, with the ventral premotor cortex processing the illusory feeling of ownership and the inferior parietal lobule and cerebellum processing proprioceptive drift. We applied the rubber hand illusion task to healthy subjects and to patients affected by two different types of focal dystonia-one specifically affecting the hand (focal hand dystonia) and one not affecting the hand (torticollis and blepharospasm). Results showed that in patients with focal hand dystonia, the proprioceptive drift was selectively disrupted on the dystonic hand while the subjective experience of the illusion was retained. In the non-dystonic hand and in the other two groups (non-hand dystonia and healthy subjects), the rubber hand illusion resembled the typical pattern with synchronous stroking eliciting the illusion. These findings provide support for the contention that the mechanisms underlying the presence of the illusory feeling of ownership and the proprioceptive drift are different. Selective impairment of the limb recalibration on the dystonic hand points to underlying deficits in integrating the visual-tactile input with the proprioceptive information in order to update the current body position and may support a model linking dystonia to dysfunctions in a network comprising the inferior parietal cortex and the cerebellum.