RESUMO
PURPOSE: To evaluate and compare the morbidity and mortality of neonates born to pregnant women with positive and negative cervical cultures. MATERIALS AND METHODS: The demographic and clinical features of mothers included in this study, along with details of the microorganisms isolated on maternal cervical cultures and the number of days between a positive cervical culture and delivery were recorded. Neonates were stratified into two groups based on cervical culture results of their mothers--Group 1, positive cervical culture; Group 2, negative cervical culture. RESULTS: A total of 216 women who delivered 242 infants were included in the study. Group 1 consisted of 90 neonates while Group 2 had 152 newborns. The difference between the groups with demographic characteristics was statistically insignificant. Mean levels of the acute phase reactants, CRP, and IL-6, obtained six hours after delivery were significantly higher in Group 1 compared to Group 2 (p < 0.05 for C-reactive protein (CRP) andp < 0.001 for IL-6). Although there was no difference between groups in terms of duration of respiratory support, mean duration of hospitalization, as well as mortality rate were significantly higher in Group 1 (p < 0.001, p < 0.05, respectively). CONCLUSIONS: Women diagnosed with a high-risk pregnancy should be treated with antibiotics immediately after a positive cervical culture result, and delivery should be delayed until the success of antibiotic treatment can be evaluated. Early initiation of maternal antibiotic therapy is associated with shorter durations of hospital stay for newborns. Close follow-up of mothers with high-risk pregnancies and extension of treatment duration are critical for determining prognosis in newborn infants.
Assuntos
Colo do Útero/microbiologia , Doenças do Prematuro/epidemiologia , Adulto , Antibacterianos/administração & dosagem , Corioamnionite/tratamento farmacológico , Corioamnionite/epidemiologia , Corioamnionite/microbiologia , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/epidemiologia , Feminino , Humanos , Recém-Nascido , Doenças do Prematuro/mortalidade , Masculino , Gravidez , Resultado da Gravidez , Gravidez de Alto Risco , Estudos Retrospectivos , Turquia/epidemiologiaRESUMO
Jarcho-Levin syndrome (JLS) is a genetic disorder characterized by defects of spine formation, abnormal fusion of the ribs at the costovertebral and costochondral junction due to abnormal vertebral and costal segmentation. There are two subtypes associated with different distribution and severity of defects in JLS. While vertebral segmentation abnormalities are frequent in spondylo-thoracic subtype costal segmentation and fusion abnormalities are frequent in spondylo-costal subtype. Neural tube defects with severe hydrocephalus are rare findings in this syndrome. Herein we report three infants with severe hydrocephalus associated with Jarcho-Levin syndrome.
Assuntos
Cardiopatias Congênitas/complicações , Hérnia Diafragmática/complicações , Hidrocefalia/etiologia , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/patologia , Feminino , Cardiopatias Congênitas/genética , Cardiopatias Congênitas/patologia , Hérnia Diafragmática/genética , Hérnia Diafragmática/patologia , Humanos , Hidrocefalia/genética , Hidrocefalia/patologia , Recém-Nascido , Masculino , Índice de Gravidade de DoençaRESUMO
Holoprosencephaly is frequently accompanied by midline facial abnormalities such as hypotelorism, cyclopia, etmocephaly and cebocephaly. Cebocephaly is a very rare congenital anomaly combining with semilobar holoprosencephaly. Chromosomal analysis shows normal karyotyping. Lissencephaly and holoprosencephaly are rare associations, that have not been reported yet with cebocephaly. Herein we present the first case of cebocephaly with severe semilobar holoprosencephaly and lissencephaly.
Assuntos
Anormalidades Múltiplas/diagnóstico , Anormalidades Craniofaciais/diagnóstico , Holoprosencefalia/diagnóstico , Lisencefalia/diagnóstico , Anormalidades Múltiplas/epidemiologia , Anormalidades Múltiplas/genética , Comorbidade , Anormalidades Craniofaciais/epidemiologia , Anormalidades Craniofaciais/genética , Feminino , Holoprosencefalia/epidemiologia , Holoprosencefalia/genética , Humanos , Recém-Nascido , Lisencefalia/epidemiologia , Lisencefalia/genética , Índice de Gravidade de DoençaRESUMO
Ritscher-Schinzel also known as cranio-cerebello-cardiac (3C) syndrome is a very rare clinical entity. The striking features of this syndrome are cerebellar, cardiac and craniofacial abnormalities. Life threatening features of this syndrome are generally associated with cardiac abnormalities. We here present prolonged respiratory problems due to pulmonary hypertension in a preterm baby with Ritscher-Schinzel syndrome.
Assuntos
Displasia Broncopulmonar/etiologia , Anormalidades Craniofaciais/complicações , Síndrome de Dandy-Walker/complicações , Comunicação Interatrial/complicações , Síndrome do Desconforto Respiratório do Recém-Nascido/etiologia , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/fisiopatologia , Anormalidades Craniofaciais/genética , Anormalidades Craniofaciais/fisiopatologia , Síndrome de Dandy-Walker/genética , Síndrome de Dandy-Walker/fisiopatologia , Feminino , Comunicação Interatrial/genética , Comunicação Interatrial/fisiopatologia , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Doenças do Prematuro , Síndrome do Desconforto Respiratório do Recém-Nascido/complicaçõesRESUMO
Ulnar dimelia or commonly called mirror hand is a rare congenital anomaly of upper extremity characterized by duplication of ulna, absence of the radius with symmetrical polydactyly. This anomaly may be associated with shoulder dislocation, fibular dimelia, idiopathic scoliosis, cirrhosis, pyloric hypertrophy or polycystic kidney. We report a new case of this rare congenital anomaly which was not associated with any other malformation.