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Pain Med ; 14(3): 422-9, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23279572

RESUMO

OBJECTIVE: Neuropathic pain is a challenge in children with burn sequelae. Although relatively infrequent, the intensity and chronicity of neuropathic pain negatively impact functionality and quality of life. The use of 5% lidocaine medicated plaster has not previously been reported in children. We explored the effectiveness and safety of 5% lidocaine medicated plaster to treat neuropathic pain in children with burn sequelae. DESIGN: Three-month prospective, uncontrolled study. SETTING: Corporation of Aid to Burned Children (COANIQUEM), a nonprofit pediatric burn rehabilitation center in Chile. SUBJECTS: Fourteen pediatric patients with burn sequelae neuropathic pain. OUTCOME MEASURES: Demographics, burn and pain evolution (type, intensity [using Wong-Baker FACES], and Douleur Neuropathique 4 [DN4]), and patient functionality. Plasma lidocaine levels were measured at 0, 12, 36, and 60 hours after treatment commencement. RESULTS: Fourteen patients were evaluable for plasma lidocaine levels. Twelve patients were available for clinical assessment (two patients lost to follow-up) [mean (standard deviation)]: age, 11 years 7 months (2 years 6 months); weight, 45 kg (11.9 kg); burn evolution, 5 years 6 months (4 years); time between burn and pain onset, 3 years 6 months (3 years 2 months); time between pain onset and treatment, 5.1 months (4.8 months); lidocaine, between < and ½ plaster; initial pain intensity (FACES), 6.8 (1.6); final pain intensity, 0 in 11/12 patients; DN4, initial-6, final-2.3. All patients reported improved functionality. Plasma lidocaine levels were ≤27.45 ng/mL (>180 times below critical levels). No adverse reactions occurred. CONCLUSIONS: These are the first published data suggesting that 5% lidocaine medicated plaster improves patient functionality, and is effective and safe for the treatment of neuropathic pain in pediatric patients with burn sequelae.


Assuntos
Anestésicos Locais/administração & dosagem , Bandagens , Queimaduras/complicações , Lidocaína/administração & dosagem , Neuralgia/tratamento farmacológico , Administração Cutânea , Adolescente , Anestésicos Locais/sangue , Criança , Feminino , Humanos , Lidocaína/sangue , Masculino , Neuralgia/etiologia , Estudos Prospectivos , Resultado do Tratamento
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