[Esterase activity of neutrophils and monocytes in patients with stenocardia and myocardial infarction]. / Esteraznaia aktivnost' neitrofilov i monotsitov krovi u bol'nykh stenokardiei i infarktom miokarda.

Neutrophils and monocytes of coronary patients and healthy subjects were investigated for activity of alpha-naphthylacetate esterase, naphthol--AS--D+chloroacetate esterase, alpha-naphthylbutyrate esterase. This activity varied from healthy to coronary subjects, among anginal and MI sufferers, etc. The fact made the authors to suggest comprehensive evaluation of monocyte and neutrophil esterase activity as a diagnostic and prognostic indicator.

Medical efficacy of a cooperative prevention programme of arterial hypertension.

The study included 43,197 men aged 40-54 years, of whom 23,378 were in the intervention group and 19,819 in the comparison group; the number of man-years of follow-up totalled for the whole group 177,703. The study proved the efficacy of active, predominantly secondary prevention of arterial hypertension (AH), carried out in men aged 40-54 years over a period of 3-5 years in 12 centres within the framework of the cooperative programme. In comparison with the control group, the following changes were registered in the intervention group: 1) overall mortality decreased by 17.3%; 2) stroke mortality decreased by 48.4%; 3) non-lethal stroke morbidity decreased by 51.4%; 4) morbidity of non-fatal myocardial infarction decreased in the course of four years by 23.8%. In contrast to this, mortality due to ischaemic heart disease was in the intervention group and in the control group practically the same.

[Effect of fibrinolysin and heparin on the kinetic properties of the thrombocytes and the oxidation-reduction processes in myocardial infarct]. / Vliianie fibrinolizina i geparina na kineticheskie svoistva trombotsitov i protsessy oksidoreduktsii u bol'nykh infarktom miokarda.

Complex study of blood platelet adhesion and aggregation, blood coagulation activity and oxidation-reduction processes was conducted in dynamics in 340 patients with myocardial infarction. in 53 of them before and after treatment with fibrinolysin and heparin. It is shown that in patients with myocardial infarction, particularly in the first days of the disease and with the development of cardiogenic shock and pulmonary edema, the adhesion and aggregation of blood platelets increase with parallel increase in the content of incompletely oxidized products in the blood. A definite parallelism was found between the changes in the kinetic properties of platelets and the oxidoreduction processes. A decrease in the platelet kinetic properties and improvement in the oxidation-reduction processes due to the effect of fibrinolysin and heparin were observed.

[Detection of alpha2H-globulin in the blood serum in myocardial infarct]. / O vyiavlenii al'fa2H-globulina v syvorotke krovi bol'nykh infarktom miokarda.

The content of alpha2H-globulin in the plasma of 53 patients with macrofocal and 33 patients with microfocal myocardial infarction was determined in dynamics by the immunochemical method, with due account for the form and severity of the disease, the extent of involvement of the heart muscle, and the presence of complications and concomitant pathologic conditions of the lungs and kidneys. The frequency of alpha2H-globulin detection was 62% in macrofocal and 21% in microfocal myocardial infarction. In transmural myocardial infarction alpha2H-globulin is detected within the first 3 days of the disease in 37.5% of cases. The appearance of alpha2H-globulin in the blood plasma of patients with myocardial infarction is evidently associated with hypoxia and cell regeneration.