RESUMO
BACKGROUND: Wearable sensors are increasingly being explored in healthcare, including in cancer care, for their potential in continuously monitoring patients. Despite their growing adoption, significant challenges remain in the quality and consistency of data collected from wearable sensors. In particular, preprocessing pipelines to clean and standardize raw data have not been fully optimized. OBJECTIVE: The aim of this study was to conduct a systematic review of preprocessing techniques employed on wearable sensor data to ensure their readiness for artificial intelligence/machine learning ("AI/ML-ready") applications. Specifically, we sought to understand the landscape of current approaches applied in cleaning, normalizing, and transforming raw datasets into usable formats for subsequent AI/ML analysis. METHODS: We systematically searched IEEE Xplore, PubMed, Embase (including Embase, Embase Classic, MEDLINE, PubMed-not-MEDLINE), and Scopus to identify potentially relevant studies for this review. The eligibility criteria included: (1) mHealth and wearable sensor studies in cancer; (2) written and published in English; (3) published between January 2018 and December 2023; (4) full text available rather than abstracts; (5) original studies published in peer-reviewed journals or appeared in conference proceedings. The Covidence app was used as a review resource for the screening stage. Statistical learning and image processing techniques were considered irrelevant. RESULTS: In the initial phase, 2,147 papers were identified between January 2018-December 2023. After a thorough evaluation of these selected papers, we applied our predefined eligibility criteria, which resulted in a total of 20 papers. The following three categories for preprocessing techniques were identified: (1) Data Transformation, (2) Data Scaling, (3) and Data Cleaning. CONCLUSIONS: While wearable sensors are gaining traction in cancer care, there remain challenges in the application of standard AI/ML techniques due to low quality of raw data captured and not applying appropriate preprocessing pipelines to enrich the data quality. As of now, AI/ML methodologies remain individually tailored to specific studies or types of data, and limit the generalizability of research findings. A general framework for those multiple types of databases has been proposed in this work. Our findings suggest a pressing need to develop and adopt uniform data quality and pre-processing workflows of wearable sensor data that can support the breadth of cancer research and its diverse patient populations.
RESUMO
BACKGROUND: Twenty-four-hour heart rate (HR) integrates multiple physiological and psychological systems related to health and well-being, and can be continuously monitored in high temporal resolution over several days with wearable HR monitors. Using HR data from two independent datasets of cancer patients and their caregivers, we aimed to identify dyadic and individual patterns of 24 h HR variation and assess their relationship to demographic, environmental, psychological, and clinical variables of interest. METHODS: a novel regularized approach to high-dimensional canonical correlation analysis (CCA) was used to identify factors reflecting dyadic and individual variation in the 24 h (circadian) HR trajectories of 430 people in 215 dyads, then regression analysis was used to relate these patterns to explanatory variables. RESULTS: Four distinct factors of dyadic covariation in circadian HR were found, contributing approximately 7% to overall circadian HR variation. These factors, along with non-dyadic factors reflecting individual variation exhibited diverse and statistically robust patterns of association with explanatory variables of interest. CONCLUSIONS: Both dyadic and individual anomalies are present in the 24 h HR patterns of cancer patients and their caregivers. These patterns are largely synchronous, and their presence robustly associates with multiple explanatory variables. One notable finding is that higher mood scores in cancer patients correspond to an earlier HR nadir in the morning and higher HR during the afternoon.