Results of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in a Cohort of 319 Embryos: Experience in a Fertility Clinic in Colombia.

OBJECTIVE: To analyze the results of the preimplantation genetic testing for aneuploidy at the Instituto de Fertilidad Humana - Inser Bogotá, Colombia, from 2016 to 2020. METHODS: This study is an observational, retrospective, and correlative analysis of biopsies from 319 embryos (from 54 patients) submitted to preimplantation genetic testing for aneuploidy by different molecular techniques. RESULTS: Of the 54 patients included in the study, 42 provided their own oocytes, and 12 used donated oocytes. The main indication to perform the preimplantation genetic testing was advanced maternal age. We obtained 319 embryos: Ninety-one (28.5%) euploid, 197 (61.8%) aneuploid and 31 (9.7%) with no detectable DNA. The highest rate of aneuploid embryos was found in patients over 40 years (72.7%), and the euploidy rate in patients under 35 years was 37.1%. After the transfer of euploid embryos, the rates for implantation, ongoing pregnancy, live birth, and miscarriage were 40%, 50%, 40.6%, and 0%, respectively. Older maternal age correlated with higher numbers of aneuploid embryos and lower numbers of both euploid and 5-day embryos. CONCLUSIONS: There was a positive correlation between maternal age and aneuploidy rate. Complex chromosomal abnormalities were the most frequent aneuploidies, followed by mosaicism and double aneuploidies. The miscarriage rate after the transfer of euploid embryos was 0 %.

La valoración de la importancia en el autoreporte de la calidad de vida en la adultez / Weight of specific domains on the overall quality of life according to the assessment of participants

Background: Usually quality of life self-reports are standard and consider that all the areas evaluated are equally important. Aim: To explore the influence of specific domains on the overall quality of life self-assessment. Material and Methods: The brief version of the quality of life questionnaire developed by the World Health Organization (WHOQoL bref) was applied to 1229 participants aged 19 to 60 years (53% women). The questionnaire explores four domains: physical and psychological health, social relationships and environment. At the end of each domain a new question asking the participant to assess the importance of the domain, using a scale of 1 (not important) to 5 (very important), was added. The analysis of data considered the assessment of the importance of each domain made by participants. The weight of each domain was analyzed using regression equations. Results: The physical health had the best evaluation followed by the social domain. The environmental domain received the lower evaluation. Among women, social domain was the best evaluated domain and among men, the physical health domain. According to participants, physical and psychological health had the higher weight. The environmental domain had the higher weight on the overall assessment of quality of life. Conclusions: According to participants, physical and psychological health are the most important aspects that influence overall quality of life.

[Weight of specific domains on the overall quality of life according to the assessment of participants]. / La valoración de la importancia en el autoreporte de la calidad de vida en la adultez.

BACKGROUND: Usually quality of life self-reports are standard and consider that all the areas evaluated are equally important. AIM: To explore the influence of specific domains on the overall quality of life self-assessment. MATERIAL AND METHODS: The brief version of the quality of life questionnaire developed by the World Health Organization (WHOQoL bref) was applied to 1229 participants aged 19 to 60 years (53% women). The questionnaire explores four domains: physical and psychological health, social relationships and environment. At the end of each domain a new question asking the participant to assess the importance of the domain, using a scale of 1 (not important) to 5 (very important), was added. The analysis of data considered the assessment of the importance of each domain made by participants. The weight of each domain was analyzed using regression equations. RESULTS: The physical health had the best evaluation followed by the social domain. The environmental domain received the lower evaluation. Among women, social domain was the best evaluated domain and among men, the physical health domain. According to participants, physical and psychological health had the higher weight. The environmental domain had the higher weight on the overall assessment of quality of life. CONCLUSIONS: According to participants, physical and psychological health are the most important aspects that influence overall quality of life.