RESUMO
PURPOSE: We treated five patients who had ocular fungal infections with oral fluconazole to determine its safety and effectiveness. METHODS: We reviewed the case histories of the five patients. One patient had coccidioidomycosis and four had endogenous Candida endophthalmitis. RESULTS: The intraocular fungal infection resolved in all patients. CONCLUSION: Fluconazole appears to be a safe and effective antifungal agent that can be administered orally and may be a useful agent for treating some intraocular fungal infections.
Assuntos
Candidíase/tratamento farmacológico , Coccidioidomicose/tratamento farmacológico , Endoftalmite/tratamento farmacológico , Infecções Oculares Fúngicas/tratamento farmacológico , Fluconazol/uso terapêutico , Administração Oral , Adulto , Idoso , Tolerância a Medicamentos , Endoftalmite/microbiologia , Feminino , Fluconazol/administração & dosagem , Fluconazol/efeitos adversos , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A rare case of "late onset' endocarditis due to Bacillus cereus occurred in a 55-year-old man who had a Carpentier-Edwards heterograft valve. Combination therapy with gentamicin and clindamycin was administered as suggested by testing of minimal bactericidal concentrations for these antibiotics. Valve replacement was necessary because of a paravalvular leak. There was no recurrence after six weeks of therapy.
Assuntos
Bacillus cereus/patogenicidade , Bioprótese/efeitos adversos , Endocardite Bacteriana/microbiologia , Próteses Valvulares Cardíacas/efeitos adversos , Valva Aórtica/cirurgia , Clindamicina/uso terapêutico , Endocardite Bacteriana/tratamento farmacológico , Gentamicinas/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , ReoperaçãoRESUMO
Elderly individuals are particularly susceptible to hospital-acquired infections, partly as a result of underlying chronic conditions that predispose to infection and influence prognosis. Prior antibiotic therapy may allow for colonization with resistant organisms and thus increase the risk of the development of bacterial pneumonia and other infections.
Assuntos
Infecção Hospitalar/etiologia , Geriatria , Adolescente , Idoso , Antibacterianos/uso terapêutico , Infecção Hospitalar/complicações , Infecção Hospitalar/tratamento farmacológico , Feminino , Gastroenteropatias/complicações , Gastroenteropatias/tratamento farmacológico , Humanos , Masculino , Meningite por Listeria/complicações , Meningite por Listeria/tratamento farmacológico , Pré-Medicação , Infecções Respiratórias/complicações , Infecções Respiratórias/tratamento farmacológico , Dermatopatias/complicações , Dermatopatias/tratamento farmacológico , Cateterismo Urinário/efeitos adversosRESUMO
Maternal infections are unique because of their implications for the outcome of pregnancy. Bacterial infections that can be favorably influenced by prompt diagnosis and preventive management include urinary tract infections and chorioamnionitis. However, viral infections such as genital herpes and cytomegalovirus, and the parasitic disease toxoplasmosis, require specialized forms of testing and a complicated management plan. Altered physiological and immunological states during pregnancy are important in understanding the pathophysiology of maternal infections.