Change of dominant material properties in laser perforation process with high-energy lasers up to 120 kilowatt.

In laser materials processing, energy losses due to reflection, heat conduction and thermal radiation play an important role. In this publication, we show that with increasing laser intensity, the energy lost within the sample becomes less important for metal perforation processes. We compare the laser-matter interaction of aluminum and steel plates. Material parameters such as density, melting point and especially thermal conductivity differ strongly, leading to much longer perforation times for aluminum in comparison to steel at laser powers of 20 kW. However, this behavior changes at laser powers of more than 80 kW where the perforation times of aluminum become shorter than the corresponding times for steel. By comparing experimental data and simulations, we conclude that thermal conduction is the dominant factor of energy loss at low powers, but is reduced at high laser powers.

2D and 3D Triangulation Are Suitable In Situ Measurement Tools for High-Power Large Spot Laser Penetration Processes to Visualize Depressions and Protrusions before Perforating.

During laser penetration, the irradiated samples form a melt pool before perforation. Knowledge of the dynamics of this melt pool is of interest for the correct physical description of the process and leads to improved simulations. However, a direct investigation, especially at the location of high-power laser interaction with large spot diameters in the centimeter range is missing until now. Here, the applicability of 2D triangulation for surface topology observations is demonstrated. With the designed bidirectional 2D triangulation setup, the material cross-section is measured by profile detection at the front and back side. This allows a comprehensive description of the penetration process to be established, which is important for a detailed explanation of the process. Specific steps such as surface melting, indentations, protrusions during melt pool development and their dynamics, and the perforation are visualized, which were unknown until now. Furthermore, a scanning 3D triangulation setup is developed to obtain more information about the entire melt pool at the front side, and not just a single intersection line. The measurements exhibit a mirror-symmetric melt pool and the possibility to extrapolate from the central profile to the outer regions in most cases.

Continuous wave high-power laser propagation in water is affected by strong thermal lensing and thermal blooming already at short distances.

When laser beams propagate through media with non-vanishing absorption, the media is heated resulting in a change of the refractive index, which can lead to thermal lensing and thermal blooming. However, experimental details about both phenomena for propagations in water are lacking, especially for high-power lasers in the kilowatt range. We show that significant thermal lensing occurs only for high input powers before the onset of convective flow, while for low input powers, no strong thermal lens arises. After the onset of water flow, thermal blooming occurs at low input powers comparable to that known for propagations over kilometres in the air. However, for high input powers a thermal blooming on a qualitatively higher level is shown. By wavefront sensing, the change of refractive index distribution in water is investigated. This clearly shows the fast development of a strong thermal lens for high input powers and the onset of convection. Furthermore, a qualitatively good agreement of the accompanying simulations is observed. It is found that the absorption coefficient is linear with a value of [Formula: see text] at least up to 7.5 kW, i.e. 8 [Formula: see text]. However, the directed transmission into an aperture is only constant before any thermal lensing of blooming occurs.

Characterization of a setup to test the impact of high-amplitude pressure waves on living cells.

The impact of pressure waves on cells may provide several possible applications in biology and medicine including the direct killing of tumors, drug delivery or gene transfection. In this study we characterize the physical properties of mechanical pressure waves generated by a nanosecond laser pulse in a setup with well-defined cell culture conditions. To systematically characterize the system on the relevant length and time scales (micrometers and nanoseconds) we use photon Doppler velocimetry (PDV) and obtain velocity profiles of the cell culture vessel at the passage of the pressure wave. These profiles serve as input for numerical pressure wave simulations that help to further quantify the pressure conditions on the cellular length scale. On the biological level we demonstrate killing of glioblastoma cells and quantify experimentally the pressure threshold for cell destruction.

Controlled reproducible alignment of cone targets and mitigation of preplasma in high intensity laser interactions.

The use of cone targets in high intensity laser-plasma experiments has been of recent interest because of their potential use in integrated fast ignition experiments. Simpler experiments provide a good avenue for understanding the underlying physics, however precise control of the alignment along with good pointing accuracy is of crucial importance. While on big laser facilities target alignment is done precisely with several microscopes, it is not always the case on smaller facilities. This can have a detrimental effect on the quality of the results. We have developed and characterized a method for accurate alignment of intense laser pulses into a cone target. This, along with optimal positioning of the focus compared to the tip, efficiently uses the shape of the target to microfocus the laser light and concentrates the hot electrons in the tip, and can mitigate preplasma issues.

Measurement of the coagulation dynamics of bovine liver using the modified microscopic Beer-Lambert law.

BACKGROUND AND OBJECTIVES: During heating, the optical properties of biological tissues change with the coagulation state. In this study, we propose a technique, which uses these changes to monitor the coagulation process during laser-induced interstitial thermotherapy (LITT). STUDY DESIGN/MATERIALS AND METHODS: Untreated and coagulated (water bath, temperatures between 35 degrees C and 90 degrees C for 20 minutes.) samples of bovine liver tissue were examined using a Nd:YAG (lambda = 1064 nm) frequency-domain reflectance spectrometer. We determined the time integrated intensities (I(DC)) and the phase shifts (Phi) of the photon density waves after migration through the tissue. From these measured quantities, the time of flight (TOF) of the photons and the absorption coefficients of the samples were derived using the modified microscopic Beer-Lambert law. RESULTS: The absorption coefficients of the liver samples decreased significantly with the temperature in the range between 50 degrees C and 70 degrees C. At the same time, the TOF of the investigated photos was found increased indicating an increased scattering. The coagulation dynamics could be well described using the Arrhenius formalism with the activation energy of 106 kJ/mol and the frequency factor of 1.59 x 10(13)/second. CONCLUSIONS: Frequency-domain reflectance spectroscopy in combination with the modified microscopic Beer-Lambert (MBL) is suitable to measure heat induced changes in the absorption and scattering properties of bovine liver in vitro. The technique may be used to monitor the coagulation dynamics during local thermo-coagulation in vivo.

Small-volume frequency-domain oximetry: phantom experiments and first in vivo results.

We describe a new method to determine the oxygen saturation and the total hemoglobin content of tissue in vivo absolutely at small source-detector separations (<10 mm). Phase and mean intensity of modulated laser light of various wavelengths was measured at several predetermined source-detector separations in the frequency domain. From these measured quantities, the absorption coefficient was derived using the modified time-integrated microscopic Beer-Lambert law (MBL). In addition, the interaction volume of the photons was determined using a multi-layer Monte-Carlo model of human skin. To evaluate the method, we employed homogenous solid phantoms (consisting of TiO2 particles embedded in resin) with mean scattering and absorbing properties comparable to those of human skin. Furthermore, in vivo measurements were performed in a healthy volunteer to demonstrate that the technique is applicable for the determination of the oxygen saturation and the total hemoglobin content in the skin in vivo. The proposed technique is especially suited for the on-line determination of the oxygen saturation and total hemoglobin content in applications where small applicators are required (e.g., fetal oxygen monitoring sub partu).