Assuntos
Arachis/imunologia , Técnicas e Procedimentos Diagnósticos/normas , Glycine max/imunologia , Isotretinoína/uso terapêutico , Hipersensibilidade a Amendoim/tratamento farmacológico , Anafilaxia/imunologia , Anafilaxia/prevenção & controle , Antígenos de Plantas/imunologia , Arachis/efeitos adversos , Bases de Dados Factuais , Fármacos Dermatológicos/administração & dosagem , Fármacos Dermatológicos/uso terapêutico , Humanos , Imunoglobulina E/imunologia , Isotretinoína/administração & dosagem , Monitorização Fisiológica/métodos , Hipersensibilidade a Noz/tratamento farmacológico , Hipersensibilidade a Noz/imunologia , Hipersensibilidade a Noz/prevenção & controle , Hipersensibilidade a Amendoim/imunologia , Óleo de Soja/metabolismo , Glycine max/efeitos adversosAssuntos
Isotretinoína , Hipersensibilidade a Amendoim , Humanos , Imunoglobulina E , Testes CutâneosAssuntos
Fármacos Dermatológicos/uso terapêutico , Isotretinoína/uso terapêutico , Hipersensibilidade a Amendoim/tratamento farmacológico , Óleos de Plantas/efeitos adversos , Adolescente , Adulto , Contraindicações , Fármacos Dermatológicos/química , Feminino , Humanos , Isotretinoína/química , Masculino , Hipersensibilidade a Amendoim/prevenção & controle , Óleo de Amendoim , Reino Unido , Adulto JovemRESUMO
An 82-year-old man presented with multiple, exquisitely painful skin metastases from an atypical carcinoid tumour of the larynx. These were treated successfully with carbon dioxide laser. To our knowledge, this is the first reported case of laser treatment used in the management of neuroendocrine skin metastases.
Assuntos
Carcinoma Neuroendócrino/cirurgia , Neoplasias Laríngeas/cirurgia , Dor/cirurgia , Neoplasias Cutâneas/cirurgia , Idoso de 80 Anos ou mais , Carcinoma Neuroendócrino/patologia , Carcinoma Neuroendócrino/secundário , Humanos , Neoplasias Laríngeas/secundário , Lasers de Gás , Masculino , Neoplasias Cutâneas/patologiaAssuntos
Antioxidantes/efeitos adversos , Benzoquinonas/efeitos adversos , Cosméticos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Fármacos Dermatológicos/efeitos adversos , Administração Cutânea , Adulto , Dermatite Alérgica de Contato/diagnóstico , Feminino , Humanos , Testes do Emplastro , Envelhecimento da Pele , Ubiquinona/análogos & derivadosRESUMO
We describe four patients in whom porokeratosis coexisted with lympoedema of the legs. A possible pathogenetic link between the two disorders is discussed, as well as the therapeutic implications and the novel physical sign of lymphoedema bulging through the porokeratotic lesions.
Assuntos
Dermatoses da Perna/etiologia , Linfedema/complicações , Poroceratose/etiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Dermatoses da Perna/patologia , Poroceratose/patologiaRESUMO
We have studied patients who have positive-patch test reactions to fragrance-allergic screening substances fragrance mix (FM) or Myroxylon pereirae resin (balsam of Peru) for immediate contact reactions to the standard FM, the constituents of the FM and Myroxylon pereirae resin. In the fragrance-positive subjects (n = 60), there were positive immediate contact reactions to Myroxylon pereirae resin in 56.6% and to FM in 11.6%. In a control group (n = 50) of eczematous, patch test-negative patients there were positive immediate reactions to Myroxylon pereirae resin in 58.0% subjects and to FM in 12.0%. The absence of a significant difference between the fragrance-allergic group and control group is in keeping with a non-immunological basis for the majority of the immediate reactions seen.
Assuntos
Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Myroxylon/efeitos adversos , Perfumes/efeitos adversos , Resinas Vegetais/efeitos adversos , Adulto , Bálsamos/efeitos adversos , Estudos de Casos e Controles , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/patologia , Feminino , Humanos , Masculino , Testes do Emplastro/métodosAssuntos
Internet , Dermatopatias/diagnóstico , Diagnóstico por Computador , Humanos , Listas de EsperaAssuntos
Dermatite Ocupacional/etiologia , Dermatoses da Mão/induzido quimicamente , Hipersensibilidade ao Látex/induzido quimicamente , Psoríase/etiologia , Adulto , Dermatite Ocupacional/complicações , Dermatite Ocupacional/patologia , Feminino , Luvas Cirúrgicas/efeitos adversos , Dermatoses da Mão/patologia , Humanos , Hipersensibilidade ao Látex/patologia , Exposição Ocupacional/efeitos adversos , Testes do Emplastro , Psoríase/patologia , Tiram/efeitos adversosRESUMO
OBJECTIVE: Previous endocrine studies of women with acne have produced diverse results. This study was designed to seek evidence, from endocrine and genetic studies, for impaired steroid biosynthesis in patients with acne. DESIGN: Adrenal stimulation tests with synthetic adrenocorticotrophic hormone (ACTH) were performed. MEASUREMENTS: Steroid hormones were measured basally and 30 minutes after ACTH. The results were correlated with analysis of the steroid 21-hydroxylase gene (CYP21). PATIENTS: Fifty-one consecutive female patients (mean age 27.1 years) referred with acne. RESULTS: The median plasma 17-hydroxyprogesterone (17-OHP) before and 30 minutes after ACTH were 2.5 nmol/l (range 1.1-8.2) and 7.3 (2.1-17.8) nmol/l which were significantly above normal female controls (n = 11, mean age 25.6 years) at 1.5 (0.9-4.2) and 4.6 (2.6-8.4) nmol/l. Eighteen of 51 acne patients showed an abnormal 17-OHP response. The 21-hydroxylase gene (CYP21) was examined for major deletions and for three common point mutations in 31 of the patients (14 with exaggerated 17-OHP response). One patient had a deletion of CYP21 on one allele consistent with carrier status for the classical congenital adrenal hyperplasia (CAH). Five patients, one of whom had a normal 17-OHP response to Synacthen, were heterozygous for the val 281 leu mutation in exon 7 of the CYP21 and were therefore carriers for a mutation associated with late-onset CAH. One patient with a raised 17-OHP response was homozygous for the splice site mutation in intron 2 and one patient with a normal 17-OHP response was heterozygous for the mutation. None of the patients had the ile 172 asn mutation. Eight of the 31 acne patients who had CYP21 gene analysis were carriers for mutations in the 21-hydroxylase gene but only six would have been detected by an abnormal response of 17-OHP on stimulation. CONCLUSION: Although alterations of the CYP21 gene were more common in acne than in controls there is a poor correlation between these events and raised steroids and acne. Factors other than mild impairment of CYP21 contribute to the variability of the clinical phenotype in hyperandrogenic states including acne.
Assuntos
Acne Vulgar/etiologia , Hiperplasia Suprarrenal Congênita , 17-alfa-Hidroxiprogesterona/sangue , Acne Vulgar/enzimologia , Acne Vulgar/genética , Adolescente , Hormônio Adrenocorticotrópico , Adulto , Feminino , Deleção de Genes , Heterozigoto , Humanos , Pessoa de Meia-Idade , Fenótipo , Mutação Puntual , Esteroide 21-Hidroxilase/genéticaRESUMO
Substance P has various immunomodulatory effects, including in vitro modification of lymphocyte proliferation and cytokine release. Elevated levels of substance P and increased staining of substance P-positive nerve fibres have been reported in atopic dermatitis patients. We examined fluoresceinated substance P binding to a range of lymphocyte subsets and compared the results in atopic dermatitis, non-atopic psoriasis patients and normal controls. Fluoresceinated substance P and phycoerythrin-labelled monoclonal antibodies to CD3, CD4, CD8, CD57, CD19 and CD14 were incubated in duplicate with Ficoll-Hypaque separated peripheral blood mononuclear leukocytes. With flow cytometry the fluoresceinated substance P-positive cells were identifiable as a peak of positively fluorescent cells, and the percentages of positive cells were measured. We have demonstrated binding of fluoresceinated substance P to all subsets examined, with significantly less binding to atopic dermatitis CD3-, CD8- and CD57-positive cells. This may affect cytokine release and hence be important in the pathogenesis of atopic dermatitis.
Assuntos
Dermatite Atópica/sangue , Linfócitos/metabolismo , Substância P/sangue , Adolescente , Adulto , Feminino , Citometria de Fluxo , Fluoresceína , Fluoresceínas , Humanos , Subpopulações de Linfócitos , Masculino , Pessoa de Meia-Idade , Ficoeritrina , Ligação Proteica , Psoríase/sangueRESUMO
We report the case of a female infant with an intrauterine herpes simplex type II infection in zosteriform distribution. She was treated with several courses of intravenous acyclovir leading to healing of the skin with segmental scarring. This patient is unusual in that the infection occurred in zosteriform distribution without any evidence of systemic involvement.