[A rare case of large-cell gastric lymphoma in a patient with chronic lympholeucosis].

Chronic lympholeucosis (CLL) is a B-cell lymphoproliferative disease, the morphological substrate of which is a clone of lymphocytes similar in size and morphology to normal mature lymphocyte and similar in immunophenotype to B lymphocytes at late stages of differentiation. The occurrence of large-cell lymphoma against the background of B-CLL is called Richter syndrome. A new tumor may occur in lymph nodes, the spleen, the liver, and the gastrointestinal tract (GIT). GIT involvement in Richter syndrome is a very rare case; the authors found only six descriptions of such cases in available literature, and no such description in Russian literature. The authors adduce their own observation.

[Comprehensive diagnosis of cancer of the ovaries]. / Kompleksnaia diagnostika raka iachnikov.

Combined examination of 96 patients with different gynecological diseases included methods of ultrasound tomography, scintigraphy of the small pelvis with 99mTc-pyrophosphate, immunoscintigraphy and radioimmunoassay for determination of the blood level of CA 125. New diagnostic methods for ovarian cancer using 131I labeled monoclonal antibodies and an algorithm for data processing were developed. Of 96 patients 39 had ovarian cancer, 6 patients--uterine tumors, and 51 patients (controls) with nontumorous and benign lesions of the ovaries and uterus. The diagnostic effectiveness of these methods was determined by the indices of sensitivity, specificity and accuracy. The radioimmunoassay for determination of CA 125 possessed the highest sensitivity, ultrasound tomography showed the highest specificity and accuracy. Immunoscintigraphy with Imacis-2 was shown to possess the highest diagnostic effectiveness and unique informative value. An optimum algorithm for the use of the above methods in patients with suspected ovarian cancer was proposed on the basis of these investigations.