1.
J Antibiot (Tokyo)
; 73(6): 365-371, 2020 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32139881
RESUMO
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.
Assuntos
Antimaláricos/farmacologia , Ácidos Hidroxâmicos/farmacologia , Hypocreales/metabolismo , Plasmodium falciparum/efeitos dos fármacos , Antimaláricos/administração & dosagem , Antimaláricos/isolamento & purificação , Cloroquina/farmacologia , Resistência a Medicamentos , Ácidos Hidroxâmicos/administração & dosagem , Ácidos Hidroxâmicos/isolamento & purificação , Concentração Inibidora 50 , Japão
2.
J Antibiot (Tokyo)
; 71(7): 682-684, 2018 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29563600
RESUMO
A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-L-phenylalanyl-L-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.