RESUMO
Glycosuria generally occurs when the threshold for glucose reabsorption by the proximal renal tubule is exceeded or when reabsorption of filtered glucose is impaired. Although the discovery of glycosuria in a child will prompt screening for diabetes mellitus, it is also a sign of a rare tubulopathy called "familial renal glycosuria" (OMIM #233100). This tubulopathy is linked to a defect in the sodium-glucose co-transporter 2, encoded by the SLC5A2 gene. Here, we describe and discuss two pediatric cases in whom familial renal glycosuria was discovered fortuitously after the observation of persistently high urine glucose levels in the absence of hyperglycemia.
Assuntos
Glicosúria Renal/diagnóstico , Glicosúria Renal/urina , Adolescente , Biomarcadores/urina , Feminino , Marcadores Genéticos , Testes Genéticos , Glicosúria Renal/genética , Humanos , Lactente , Masculino , Mutação , Transportador 2 de Glucose-Sódio/genéticaRESUMO
During summer 2016, all the conditions for local mosquito-borne transmission of Zika virus (ZIKV) are met in mainland France: a competent vector, Aedes albopictus, a large number of travellers returning from ZIKV-affected areas, and an immunologically naive population. From 1 January to 15 July 2016, 625 persons with evidence of recent ZIKV infection were reported in mainland France. We describe the surveillance system in place and control measures implemented to reduce the risk of infection.
Assuntos
Aedes/virologia , Líquidos Corporais/virologia , Imunoglobulina M/sangue , Vigilância de Evento Sentinela , Viagem , Infecção por Zika virus/epidemiologia , Zika virus/isolamento & purificação , Adolescente , Adulto , Idoso , Animais , Criança , Pré-Escolar , Notificação de Doenças , Surtos de Doenças/prevenção & controle , Feminino , França/epidemiologia , Humanos , Insetos Vetores/virologia , Masculino , Pessoa de Meia-Idade , Vigilância da População , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Adulto Jovem , Zika virus/genética , Infecção por Zika virus/diagnóstico , Infecção por Zika virus/transmissãoRESUMO
Methylprednisolone (MP) pulse therapy (1 g/1.73 m2 x 3) has been used without side effects in 16 children with steroid dependent or resistant nephrosis. MP allowed a complete remission in 6 patients (group I: 37.5%), after a mean duration of 12 days; 2 of them experienced early relapse; the other patients had either a too short or no follow-up. One child was on partial remission (group II: 6%). The other patients were resistant to therapy (group III: 56%); 8 of them had a renal biopsy which showed focal glomerulosclerosis in 6 (75%). The authors point out that the main interest of methylprednisolone pulse therapy is to confirm steroid resistance.
Assuntos
Metilprednisolona/administração & dosagem , Nefrose/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Injeções Intravenosas , Injeções a Jato , Masculino , Metilprednisolona/uso terapêutico , Fatores de TempoRESUMO
The authors report a case of calcifications of an intervertebral cervical disk in a 12-year-old boy. A torticollis was the clinically revealing event. As in the majority of the published cases, the etiology remained unknown and the evolution was simple with complete regression of the calcifications.