RESUMO
Trypsin is mainly regarded as a digestive enzyme, but there is evidence that activation of protease-activated receptor-2 (PAR-2) leads to behavioral changes. There are no data on trypsin activity in the serum of animals under conditions of thirst and starvation in the available literature. In our experiments, water deprivation led to a significant (p⩽0.05) increase in trypsin activity in rats, and food deprivation led to its decrease in comparison with controls (free access to water and food). After deprived rats received water and food, a decrease in trypsin activity was observed in both experimental groups. Changes in trypsin activity under conditions of water or food deprivation and after satiation were accompanied by shifts in some biochemical parameters of the bloods. Under conditions of metabolic stress (starvation and thirst), opposite changes in trypsin activity seem to indicate its participation in the mechanisms of adequate restructuring of metabolism and maintenance of vital processes in the body.
Assuntos
Privação de Alimentos , Água , Ratos , Animais , Tripsina/metabolismo , Peptídeo Hidrolases , SedeAssuntos
Antituberculosos/administração & dosagem , Tumor Carcinoide , Pulmão , Fotoquimioterapia/métodos , Pneumonectomia/métodos , Tuberculose Pulmonar , Broncoscopia/métodos , Tumor Carcinoide/complicações , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/fisiopatologia , Tumor Carcinoide/cirurgia , Esquema de Medicação , Monitoramento de Medicamentos , Humanos , Pulmão/patologia , Pulmão/cirurgia , Masculino , Planejamento de Assistência ao Paciente , Tomografia por Emissão de Pósitrons , Cuidados Pré-Operatórios/métodos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/fisiopatologia , Tuberculose Pulmonar/radioterapia , Tuberculose Pulmonar/cirurgia , Adulto JovemAssuntos
Pneumonectomia/métodos , Complicações Pós-Operatórias , Paralisia Respiratória/etiologia , Paralisia Respiratória/fisiopatologia , Tuberculose Pulmonar/cirurgia , Adulto , Humanos , Masculino , Radiografia , Paralisia Respiratória/diagnóstico por imagem , Tuberculose Pulmonar/diagnóstico por imagemRESUMO
Viscosity of blood serum lipids was studied in children with insulin-dependent diabetes involving nitroxyl containing probes-registered by means of radiospectrometer RE 1307. The following parameters were studied: the ratios between values exhibiting the probe distribution in polar and hydrophobic phases [formula: see text] as well as between content of low polar (I+1) and high polar (I-1) spectral components. The "f' value showed the state of lipid density and the ratio [formula: see text] allowed to estimate the lipid microviscosity. 34 children of 7-15 years old with insulin-dependent diabetes were examined in dynamics of treatment under stationary conditions. Distinct metabolic impairments and aggravation of the lipid peroxidation syndrome were mainly responsible for pronounced increase in lipid viscosity. The procedure of spin probes may contribute to study of diabetes pathogenesis as well as to serve as a diagnostic means in evaluation of the disease complications at early stages.
