Application of an egocentric social network approach to examine changes in social connections following treatment for anxiety and depression: A novel measurement tool for clinical trials research?

The epidemic of loneliness and social isolation has been recognized as a public health crisis warranting the same prioritization as other public health issues today, such as obesity, substance use disorders, and tobacco use. Social disconnection is particularly prevalent and disabling among individuals with anxiety and depression, yet it is inadequately evaluated and addressed in most clinical psychology treatment research. Studies generally employ global measures of perceived connectedness, loneliness, or relationship satisfaction, limiting understanding about elements of one's social network that may change with treatment. This study examined changes in the degree (number of people nominated) and quality of one's social network from pre-to post-treatment using an egocentric social network approach in 59 adults (mean age = 30.8 years, range = 18 to 54) with clinically elevated anxiety or depression who were randomized to a cognitive and behavioral positive valence treatment versus waitlist. Participants (egos) named people in their lives (alters) with whom they discussed important issues or spent free time. For each alter, participants rated how close they felt, how close they thought the alter felt to them, and how frequently they communicated. Linear regressions, which included treatment group as a predictor, revealed no group differences in changes in network degree, perceived alter feelings of closeness, or communication frequency, despite prior findings from this sample indicating larger increases in perceived global connectedness in the treatment group. Unexpectedly, the control group reported a greater increase in perceived closeness to alters. Post-hoc analyses revealed this was explained by the treatment group identifying more distal social ties (e.g., extended family, colleagues, roommates) as alters following treatment - an outcome positively associated with global improvements in connectedness. This proof-of-concept study suggests egocentric social network surveys may provide unique information on treatment-related changes in social functioning. Suggestions are provided for adaptations to facilitate application of social network surveys to mental health treatment research.

Amplification of Positivity Treatment for Anxiety and Depression: A Randomized Experimental Therapeutics Trial Targeting Social Reward Sensitivity to Enhance Social Connectedness.

BACKGROUND: Social disconnection is common and causes significant impairment in anxiety and depressive disorders, and it does not respond sufficiently to available treatments. The positive valence system supports social bond formation and maintenance but is often hyporesponsive in people with anxiety or depression. We conducted an experimental therapeutics trial to test the hypothesis that targeting positive valence processes through cognitive and behavioral strategies would enhance responsivity to social rewards, a core mechanism underlying social connectedness. METHODS: Sixty-eight adults who endorsed clinically elevated anxiety and/or depression with social impairment were randomized 1:1:1 to 5 (n = 23) or 10 (n = 22) sessions of amplification of positivity (AMP) treatment or waitlist (n = 23). Pre- to posttreatment change in striatal activity (primary outcome) during social reward anticipation was measured using functional magnetic resonance imaging, and reactivity to a social affiliation task (secondary) and self-reported social connectedness (exploratory) were examined. Primary analyses compared AMP (doses combined) versus waitlist. A second aim was to compare the effects of different doses. RESULTS: AMP engaged the hypothesized treatment target, leading to greater striatal activation during anticipation of social rewards versus waitlist (d = 1.01 [95% CI = 0.42-1.61]; largest striatal volume). AMP yielded larger improvements in positive affect and approach behavior during the affiliation task (but not other outcomes) and social connectedness. Larger striatal and social connectedness increases were observed for 5-session versus 10-session AMP (d range = 0.08-1.03). CONCLUSIONS: Teaching people with anxiety or depression strategies to increase positive thoughts, behaviors, and emotions enhances activity in brain regions that govern social reward processing and promotes social connectedness. Social reward sensitivity may be a transdiagnostic target for remediating social disconnection.

How to Improve Others' Emotions: Reappraise and be Responsive.

People often try to improve others' emotions. However, it is unclear which interpersonal emotion regulation strategies are most effective and why. In 121 candid dyadic conversations between undergraduate students via video conferencing, target participants recounted a stressful event to regulator participants. Three strategies used by regulators during these conversations to change targets' emotions were obtained from the regulator after the conversation: extrinsic reappraisal, extrinsic suppression, and extrinsic acceptance. Perceived regulator responsiveness was obtained from targets to examine the social consequences of extrinsic emotion regulation and its mediating role in successful extrinsic emotion regulation. We found that regulators' extrinsic reappraisal use was associated with improved target emotions measured across two distinct classes of outcomes: targets' emotions during the conversation and targets' perception that the regulator improved their emotions. Regulators' extrinsic suppression and acceptance, in contrast, were not related with improved target emotions or perceptions of improvement. Instead, all extrinsic regulatory strategies were associated with improved targets' emotions when mediated by targets' perceptions of regulator responsiveness. Finally, observer-ratings of regulators' extrinsic reappraisal and suppression use were found to be consistent with regulators' self-ratings and follow the same pattern of results on the outcome measures. These findings provide insight into why the social regulation of emotions can succeed or fail and hold implications for interventions aimed at guiding people toward more successfully improving others' emotions. Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-023-00183-4.

Everyday co-presence with a romantic partner is associated with lower C-reactive protein.

Social relationships are an important driver of health, and inflammation has been proposed as a key neurobiological mechanism to explain this effect. Behavioral researchers have focused on social relationship quality to further explain the association, yet recent research indicates that relationship quality may not be as robust a predictor as previously thought. Here, building on animal models of social bonds and recent theory on close relationships, we instead investigated merely being in the physical presence of one's romantic partner. Specifically, we tested the hypothesis that spending more time co-present with a loved partner in everyday life would be associated with lower C-reactive protein (CRP). Three times over the course of one month, 100 people in romantic relationships reported how much time they spent in the same physical space as their partner in the prior 24 h, in minutes, and provided a sample of blood for CRP assay (n observations = 296). Results from multi-level models showed that when one reported spending more time in the physical presence of their partner they had lower CRP - an effect that was independent from social relationship quality explanations from the prior literature, including romantic relationship quality, hostility, and loneliness. These findings move past global assessments of social isolation to consider a novel everyday behavior that is of great interest in the non-human animal literature - spending time together -- as a potential mechanism linking high-quality relationships and physical health in adult humans. The findings also point to future research on additional behavioral mechanisms that are not dependent on stress pathways: people in high-quality relationships tend to spend enjoyable and affectionate time with one another, which may impact inflammation.

Gratitude expressions improve teammates' cardiovascular stress responses.

Gratitude expressions play a key role in strengthening relationships, suggesting gratitude might promote adaptive responses during teamwork. However, little research has examined gratitude's impact on loose tie relationships (like coworkers), and similarly little research has examined how gratitude impacts physiological stress responding or biological responses more generally. The present research uses an ecologically valid, dyadic teamwork paradigm to test how gratitude expressions impact in vivo physiological challenge and threat stress responding, assessed via a challenge-threat index composed of cardiac output and total peripheral resistance. Compared with a control condition, teammates (n = 190) who were randomly assigned to a gratitude expression manipulation showed improved biological challenge-threat responses while jointly completing an acutely stressful collaborative work task (developing a product pitch), and later while completing an individual performance task (pitching the product). During the collaborative task, gratitude expressions buffered against threat responses; during the individual task, gratitude expressions amplified challenge responses. Analyses of cardiac output (CO) and total peripheral resistance (TPR) aided in determining how cardiac outflow versus vascular constriction/dilation contributed to these effects. The finding that gratitude expressions promote adaptive biological responding at the dyadic level contributes to a growing literature on the social functions of positive emotions and gratitude, specifically. The present results also have wider implications for physiological stress in performance tasks and suggest that workplace gratitude interventions can promote adaptive stress responding in teams. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Psychometric Evaluation of a Controlled Social Affiliation Paradigm: Findings From Anxiety, Depressive Disorder, and Healthy Samples.

Social impairments are common across many psychiatric conditions. Standardized dyadic assessments intended to elicit social affiliation between unacquainted partners are used to elucidate mechanisms that disrupt relationship formation and inform possible treatment targets; however, the psychometric properties of such paradigms remain poorly understood. This study evaluated the psychometric properties of a controlled social affiliation paradigm intended to induce connectedness between a target participant and trained confederate. Individuals with an anxiety or depressive disorder diagnosis (clinical group; n = 132) and those without (control group; n = 35) interacted face-to-face with a trained confederate; partners took turns answering a series of increasingly intimate questions about themselves. Social connectedness, affect, and affiliative behavior measures were collected during the interaction. Participant symptom and social functioning measures were collected to examine validity. The paradigm elicited escalating social connectedness throughout the task for both participants and confederates. Parallel forms (i.e., different question sets) elicited similar affiliation outcomes. Self-reported (but not behavioral) affiliation differed across some demographic variables (e.g., participant gender, Hispanic ethnicity). Within-task affiliation measures were associated with one another and with global social connectedness and social anxiety symptom measures, but not with somatic anxiety measures. Clinical participants reported lower social affiliation and positive affect reactivity and higher negative affect reactivity than healthy participants. These findings provide initial psychometric support for a standardized and controlled dyadic affiliation paradigm that could be used to reliably probe social disconnection mechanisms across psychopathology.

Emotion regulation contagion: Stress reappraisal promotes challenge responses in teammates.

The current research examined the interpersonal dynamics of emotion regulation in a stressful collaborative context. Little is known about how regulating one's own stress responses impacts teammates. In this article, we propose that individual efforts to regulate emotions can impact teammates for the better. We tested hypotheses arising from this claim using a dyadic experiment (N = 266) that assessed in vivo physiological stress responses during collaborative work (a face-to-face product design task) and then individual work (a product pitch to evaluators). Throughout the experiment, the manipulated teammate was randomly assigned to reappraise their stress arousal, suppress their emotional displays, or receive no instructions. The nonmanipulated teammate received no instructions in all experimental conditions. Stress reappraisal benefited both teammates, eliciting challenge-like physiological responses (higher cardiac output, lower total peripheral resistance) relative to the suppression and control conditions. These effects were observed during both collaborative and individual work. A mediation model suggested that face-to-face interpersonal effects of stress reappraisal fed forward to promote nonmanipulated teammates' improved stress responses during individual performance. Moreover, manipulated teammates' displays of positive and negative affect emerged as potential mechanisms for improvements in nonmanipulated teammates' stress responses in moderation analyses. Thus, participants benefited by interacting with a person who reappraised their stress as functional. This work has theoretical implications for the interpersonal dynamics of emotion regulation, and relevance for applied settings is also discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

A new perspective on the social functions of emotions: Gratitude and the witnessing effect.

We propose a novel theoretical and empirical approach to studying group-level social functions of emotions and use it to make new predictions about social consequences of gratitude. Here, we document the witnessing effect: In social groups, emotional expressions are often observed by third-party witnesses-family members, coworkers, friends, and neighbors. Emotional expressions coordinate group living by changing third-party witnesses' behavior toward first-party emotion expressers and toward second-party people to whom emotion is expressed. In 8 experiments (N = 1,817), we test this for gratitude, hypothesizing that third-party witnesses will be more helpful and affiliative toward a first party who expressed gratitude to a second party, as well as toward the second party, and why. In Experiments 1-3, participants who witnessed a "thank you" in 1 line of text, expressed to someone who previously helped the grateful person, were themselves more helpful toward the grateful person. In Experiment 4, witnesses of gratitude expressed to someone else via video recording subsequently self-disclosed more to the grateful person, and in Experiment 5 wanted to affiliate more with the grateful person and with the person toward whom gratitude was expressed. Experiments 6-8 used within-subjects designs to test hypothesized behavioral and social-perceptual mechanisms for these effects, with videos of real gratitude expressions. Gratitude may help build multiple relationships within a social network directly and simultaneously. By specifying proximal interpersonal mechanisms for reverberating consequences of 1 person's communicated emotion, the present work advances theory on the group-level functions of emotions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Beyond happiness: Building a science of discrete positive emotions.

While trait positive emotionality and state positive-valence affect have long been the subject of intense study, the importance of differentiating among several "discrete" positive emotions has only recently begun to receive serious attention. In this article, we synthesize existing literature on positive emotion differentiation, proposing that the positive emotions are best described as branches of a "family tree" emerging from a common ancestor mediating adaptive management of fitness-critical resources (e.g., food). Examples are presented of research indicating the importance of differentiating several positive emotion constructs. We then offer a new theoretical framework, built upon a foundation of phylogenetic, neuroscience, and behavioral evidence, that accounts for core features as well as mechanisms for differentiation. We propose several directions for future research suggested by this framework and develop implications for the application of positive emotion research to translational issues in clinical psychology and the science of behavior change. (PsycINFO Database Record

Lying because we care: Compassion increases prosocial lying.

Prosocial lies, or lies intended to benefit others, are ubiquitous behaviors that have important social and economic consequences. Though emotions play a central role in many forms of prosocial behavior, no work has investigated how emotions influence behavior when one has the opportunity to tell a prosocial lie-a situation that presents a conflict between two prosocial ethics: lying to prevent harm to another, and honesty, which might also provide benefits to the target of the lie. Here, we examine whether the emotion of compassion influences prosocial lying, and find that compassion causally increases and positively predicts prosocial lying. In Studies 1 and 2, participants evaluated a poorly written essay and provided feedback to the essay writer. Experimentally induced compassion felt toward the essay writer (Study 1) and individual differences in trait compassion (Study 2) were positively associated with inflated feedback to the essay writer. In both of these studies, the relationship between compassion and prosocial lying was partially mediated by an enhanced importance placed on preventing emotional harm. In Study 3, we found moderation such that experimentally induced compassion increased lies that resulted in financial gains for a charity, but not lies that produced financial gains for the self. This research illuminates the emotional underpinnings of the common yet morally complex behavior of prosocial lying, and builds on work highlighting the potentially harmful effects of compassion-an emotion typically seen as socially beneficial. (PsycINFO Database Record

Affective and physiological responses to the suffering of others: compassion and vagal activity.

Compassion is an affective response to another's suffering and a catalyst of prosocial behavior. In the present studies, we explore the peripheral physiological changes associated with the experience of compassion. Guided by long-standing theoretical claims, we propose that compassion is associated with activation in the parasympathetic autonomic nervous system through the vagus nerve. Across 4 studies, participants witnessed others suffer while we recorded physiological measures, including heart rate, respiration, skin conductance, and a measure of vagal activity called respiratory sinus arrhythmia (RSA). Participants exhibited greater RSA during the compassion induction compared with a neutral control (Study 1), another positive emotion (Study 2), and a prosocial emotion lacking appraisals of another person's suffering (Study 3). Greater RSA during the experience of compassion compared with the neutral or control emotion was often accompanied by lower heart rate and respiration but no difference in skin conductance. In Study 4, increases in RSA during compassion positively predicted an established composite of compassion-related words, continuous self-reports of compassion, and nonverbal displays of compassion. Compassion, a core affective component of empathy and prosociality, is associated with heightened parasympathetic activity.

Guilt enhances the sense of control and drives risky judgments.

In the present studies, we investigate the hypothesis that guilt influences risk taking by enhancing one's sense of control. Across multiple inductions of guilt, we demonstrate that experimentally induced guilt enhances optimism about risks for the self (Study 1), preferences for gambles versus guaranteed payoffs (Studies 2, 4, and 6), and the likelihood that one will engage in risk-taking behaviors (Study 5). In addition, we demonstrate that guilt enhances the sense of control over uncontrollable events, an illusory control (Studies 3, 4, and 5), and found that a model with illusory control as a mediator is consistent with the data (Studies 5 and 6). We also found that a model with feelings of guilt as a mediator but not generalized negative affect fits the data (Study 4). Finally, we examined the relative explanatory power of different appraisals and found that appraisals of illusory control best explain the influence of guilt on risk taking (Study 6). These results provide the first empirical demonstration of the influence of guilt on sense of control and risk taking, extend previous theorizing on guilt, and more generally contribute to the understanding of how specific emotions influence cognition and behavior.

Vagal activity is quadratically related to prosocial traits, prosocial emotions, and observer perceptions of prosociality.

In the present article, we introduce the quadratic vagal activity-prosociality hypothesis, a theoretical framework for understanding the vagus nerve's involvement in prosociality. We argue that vagus nerve activity supports prosocial behavior by regulating physiological systems that enable emotional expression, empathy for others' mental and emotional states, the regulation of one's own distress, and the experience of positive emotions. However, we contend that extremely high levels of vagal activity can be detrimental to prosociality. We present 3 studies providing support for our model, finding consistent evidence of a quadratic relationship between respiratory sinus arrhythmia--the degree to which the vagus nerve modulates the heart rate--and prosociality. Individual differences in vagal activity were quadratically related to prosocial traits (Study 1), prosocial emotions (Study 2), and outside ratings of prosociality by complete strangers (Study 3). Thus, too much or too little vagal activity appears to be detrimental to prosociality. The present article provides the 1st theoretical and empirical account of the nonlinear relationship between vagal activity and prosociality.

Teasing, taunting, and the politics of politeness: high sociometric status is associated with expectation-consistent behavior.

Research examining face-to-face status hierarchies suggests that individuals attain respect and admiration by engaging in behavior that influences others' judgments of their value to the group. Building on this research, we expected that high-status individuals would be less likely to engage in behaviors that violate group norms and expectations, relative to low-status individuals. Adolescent participants took part in an interaction in which they teased an opposite-gender friend (Study 1) or an experiment in which taunting or cheering expectations were manipulated (Study 2). Consistent with the hypothesis, high-status boys and girls engaged in teasing behaviors consistent with their gender roles, relative to their low status counterparts (Study 1). In Study 2, high-status boys engaged in more direct provocation and off-record commentary while taunting, and more affiliative behavior while cheering on their partner, relative to low-status boys. Discussion focused on how expectation-consistent actions help individuals maintain elevated status.

Speaking under pressure: low linguistic complexity is linked to high physiological and emotional stress reactivity.

What can a speech reveal about someone's state? We tested the idea that greater stress reactivity would relate to lower linguistic cognitive complexity while speaking. In Study 1, we tested whether heart rate and emotional stress reactivity to a stressful discussion would relate to lower linguistic complexity. In Studies 2 and 3, we tested whether a greater cortisol response to a standardized stressful task including a speech (Trier Social Stress Test) would be linked to speaking with less linguistic complexity during the task. We found evidence that measures of stress responsivity (emotional and physiological) and chronic stress are tied to variability in the cognitive complexity of speech. Taken together, these results provide evidence that our individual experiences of stress or "stress signatures"-how our body and mind react to stress both in the moment and over the longer term-are linked to how complex our speech under stress.

Transforming the mirror: power fundamentally changes facial responding to emotional expressions.

Major theories propose that spontaneous responding to others' actions involves mirroring, or direct matching. Responding to facial expressions is assumed to follow this matching principle: People smile to smiles and frown to frowns. We demonstrate here that social power fundamentally changes spontaneous facial mimicry of emotional expressions, thereby challenging the direct-matching principle. Participants induced into a high-power (HP), low-power (LP), or neutral state watched dynamic happy and angry expressions from HP and LP targets while we measured facial electromyography (fEMG) over the zygomaticus major ("smiling muscle") and corrugator supercilii ("frowning muscle"). For smiling, LP participants smiled to all targets, regardless of their expression. In contrast, HP participants exhibited standard smile mimicry toward LP targets but did not mimic the smiles of HP targets. Instead, HP participants smiled more when those HP targets expressed anger. For frowning, all participants showed a more intense mimicry pattern to HP targets. These results demonstrate that spontaneous facial responding-detected by sensitive, physiological measures of muscle activation-dynamically adapts to contextual cues of social hierarchy.

Leadership is associated with lower levels of stress.

As leaders ascend to more powerful positions in their groups, they face ever-increasing demands. As a result, there is a common perception that leaders have higher stress levels than nonleaders. However, if leaders also experience a heightened sense of control--a psychological factor known to have powerful stress-buffering effects--leadership should be associated with reduced stress levels. Using unique samples of real leaders, including military officers and government officials, we found that, compared with nonleaders, leaders had lower levels of the stress hormone cortisol and lower reports of anxiety (study 1). In study 2, leaders holding more powerful positions exhibited lower cortisol levels and less anxiety than leaders holding less powerful positions, a relationship explained significantly by their greater sense of control. Altogether, these findings reveal a clear relationship between leadership and stress, with leadership level being inversely related to stress.

To have and to hold: gratitude promotes relationship maintenance in intimate bonds.

This multimethod series of studies merges the literatures on gratitude and risk regulation to test a new process model of gratitude and relationship maintenance. We develop a measure of appreciation in relationships and use cross-sectional, daily experience, observational, and longitudinal methods to test our model. Across studies, we show that people who feel more appreciated by their romantic partners report being more appreciative of their partners. In turn, people who are more appreciative of their partners report being more responsive to their partners' needs (Study 1), and are more committed and more likely to remain in their relationships over time (Study 2). Appreciative partners are also rated by outside observers as relatively more responsive and committed during dyadic interactions in the laboratory, and these behavioral displays are one way in which appreciation is transmitted from one partner to the other (Study 3). These findings provide evidence that gratitude is important for the successful maintenance of intimate bonds.

Suppression sours sacrifice: emotional and relational costs of suppressing emotions in romantic relationships.

What happens when people suppress their emotions when they sacrifice for a romantic partner? This multimethod study investigates how suppressing emotions during sacrifice shapes affective and relationship outcomes. In Part 1, dating couples came into the laboratory to discuss important romantic relationship sacrifices. Suppressing emotions was associated with emotional costs for the partner discussing his or her sacrifice. In Part 2, couples participated in a 14-day daily experience study. Within-person increases in emotional suppression during daily sacrifice were associated with decreases in emotional well-being and relationship quality as reported by both members of romantic dyads. In Part 3, suppression predicted decreases in relationship satisfaction and increases in thoughts about breaking up with a romantic partner 3 months later. In the first two parts of the study, authenticity mediated the costly effects of suppression. Implications for research on close relationships and emotion regulation are discussed.

Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition.

Individuals who are homozygous for the G allele of the rs53576 SNP of the oxytocin receptor (OXTR) gene tend to be more prosocial than carriers of the A allele. However, little is known about how these differences manifest behaviorally and whether they are readily detectable by outside observers, both critical questions in theoretical accounts of prosociality. In the present study, we used thin-slicing methodology to test the hypotheses that (i) individual differences in rs53576 genotype predict how prosocial observers judge target individuals to be on the basis of brief observations of behavior, and (ii) that variation in targets' nonverbal displays of affiliative cues would account for these judgment differences. In line with predictions, we found that individuals homozygous for the G allele were judged to be more prosocial than carriers of the A allele. These differences were completely accounted for by variations in the expression of affiliative cues. Thus, individual differences in rs53576 are associated with behavioral manifestations of prosociality, which ultimately guide the judgments others make about the individual.