RESUMO
AIMS: In the United Kingdom, lower incidences of intraspinal abnormalities in patients with early onset idiopathic scoliosis have been observed than in studies in other countries. We aimed to determine the rates of these abnormalities in United Kingdom patients diagnosed with idiopathic scoliosis before the age of 11 years. PATIENTS AND METHODS: This retrospective study of patients attending an urban scoliosis clinic identified 71 patients satisfying a criteria of: clinical diagnosis of idiopathic scoliosis; age of onset ten years and 11 months or less; MRI screening for intraspinal abnormalities. United Kingdom census data combined with patient referral data was used to calculate incidence. RESULTS: Mean age at diagnosis was six years with 39 right-sided and 32 left-sided curves. Four patients (5.6%) were found to have intraspinal abnormalities on MRI. These consisted of: two combined Arnold-Chiari type 1 malformations with syrinx; one syrinx with a low lying conus; and one isolated syrinx. Overall annual incidence of early onset idiopathic scoliosis was one out of 182 000 (0.0006%). CONCLUSION: This study reports the lowest rates to date of intraspinal anomalies in patients with early onset idiopathic scoliosis, adding to knowledge regarding current incidences of these abnormalities as well as any geographical variation in the nature of the disease. Cite this article: Bone Joint J 2017;99-B:829-33.
Assuntos
Malformações do Sistema Nervoso/diagnóstico por imagem , Escoliose/diagnóstico por imagem , Distribuição por Idade , Idade de Início , Malformação de Arnold-Chiari/complicações , Malformação de Arnold-Chiari/diagnóstico por imagem , Malformação de Arnold-Chiari/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Imageamento por Ressonância Magnética , Masculino , Malformações do Sistema Nervoso/complicações , Malformações do Sistema Nervoso/epidemiologia , Estudos Retrospectivos , Escoliose/complicações , Escoliose/epidemiologia , Siringomielia/complicações , Siringomielia/diagnóstico por imagem , Siringomielia/epidemiologiaAssuntos
Doenças dos Animais/terapia , Homeopatia , Animais , Bovinos , Cães , Formulários Homeopáticos como AssuntoRESUMO
Aleutian disease was diagnosed as the cause of posterior ataxia and paresis in domestic ferrets. Six serologically positive animals (four clinically affected and two unaffected) were investigated in detail and seven other clinically affected ferrets were also identified. The diagnostic findings included hypergammaglobulinaemia, histological lesions in the central nervous system and parvovirus-like particles in mesenteric lymph nodes. A wider serological survey of 446 animals owned by members of a ferret club revealed an incidence of 8.5 per cent seropositive animals.
