RESUMO
PURPOSE: To evaluate the effect of PVP-I liposome hydrogel on intraperitoneal postoperative adhesions. MATERIAL AND METHODS: Thirty Wistar -Albino male rats were randomly divided into three groups. After midline laparotomy, a 1 cm(2) area of the caecum was abraded with a sterile gauze until subserosal haemorrhage had developed. A 1 x 1 cm patch of peritoneum located opposite of caecal abrasion was completely dissected. In group 1 (control group, C) adhesion induction was performed and nothing was applied to the wounds. In group 2 and 3, PVP-I solution (3%) (group 2, PI) and PVP-I liposome hydrogel (group 3, PIL) were applied to the caecal abrasion areas and peritoneal defects. Adhesions were classified according to a classification system based on the evaluation of the appearance, extent and strength of the adhesions on postoperative 2lst day. RESULTS: There was no significant difference of the adhesion scores between the groups (U1 = 45, p > 0.05 ; U2 = 48, p > 0.05 ; U3 = 47.5, p > 0.05). CONCLUSIONS: We found that PVP liposome hydrogel did not influence postoperative intraabdominal adhesions and should be further explored for its potential use in various intraabdominal procedures.
Assuntos
Hidrogel de Polietilenoglicol-Dimetacrilato/farmacologia , Enteropatias/patologia , Doenças Peritoneais/patologia , Povidona-Iodo/farmacologia , Animais , Lipossomos , Masculino , Complicações Pós-Operatórias , Distribuição Aleatória , Ratos , Ratos Wistar , Aderências Teciduais , Cicatrização/efeitos dos fármacosRESUMO
BACKGROUND: To evaluate the effect of povidone-iodine liposome hydrogel on colonic anastomosis. METHODS: 70 Wistar-Albino male rats were randomly divided into seven groups. The left colon was transected and end-to-end anastomosis was performed. PVP-I liposome hydrogel was applied around the anastomoses in groups 2 and 5. Colonic bursting pressures and tissue hydroxyproline contents were measured on postoperative days 3 and 7. RESULTS: PVP-I application did not cause any difference in the bursting pressures on postoperative day 3, but anastomotic strength was significantly increased by the use of PVP-I on postoperative day 7. The use of PVP-I liposome hydrogel had no effect on the level of perianastomotic hydroxyproline on postoperative day 3 but had positive effects on postoperativeday 7. CONCLUSIONS: We concluded that the beneficial effects of PVP-I liposome hydrogel might be due to the combination of broad-spectrum antimicrobial activity of PVP-I with the drug delivery properties and moisturizing molecular film effects of the liposome hydrogel.
