Ensuring sustainability in the reverse supply chain in case of the ripple effect: A two-stage stochastic optimization model.

The devastating impact of the ripple effect increases the importance of the reverse supply chain (RSC) design to ensure sustainability in the long-term. That being the case, in this study, a two-stage stochastic mixed-integer optimization model is proposed to design an RSC network under uncertainty sourcing from the ripple effect (i.e. external side of RSC) by considering the environmental and economic dimensions of sustainability. The environmental and economic disruptions of the ripple effect are represented by the increase in the carbon emission levels and the distance of roads, and the decrease in the capacity of facilities, respectively. Accordingly, a set of scenarios is considered based on the disruption levels (low- and high-impact) in case of the ripple effect. Furthermore, an α -reliability constraint is integrated into the model to further analyze the occurrence of scenarios. The model allows us to make integrated operational and strategic decisions by placing an emphasis on the carbon emission levels (i.e. environmental dimension) and the total cost (i.e. economic dimension). To obtain some remarkable insights, the proposed model is validated through computational experiments based on data extracted from a real case. The computational results show that the ripple effect increases the emission level and total cost up to 40%. For this reason, it suggested that the regulations regarding WEEE (Waste Electrical and Electronic Equipment) should be prepared by considering sustainability in the entire RSC network. Besides, it is realized that the centralized distribution strategy leads to a more resilient RSC network design.

Electrical failure during cardiopulmonary bypass: a critical moment.

Electrical failure during cardiopulmonary bypass is a crisis situation for the cardiac surgical team. Fortunately, it has a low incidence with low morbidity and mortality rates. Notwithstanding, institutional preventative and management measures should be taken. Here, we report a case of electrical failure during cardiopulmonary bypass, which was successfully managed during the surgery, allowing the patient to recover uneventfully. These unwanted complications can only be managed by promoting awareness and putting in place strategies against them.

Hyaluronan based heparin free coated open and closed extracorporeal circuits for high risk coronary revascularization.

This prospective randomized study compares the inflammatory response and fibrinolytic activation of fully coated/uncoated and open/closed extracorporeal circuits (ECC) in high risk patients. Over a 2-month period, 48 patients with EuroSCOREs 6 or greater undergoing coronary revascularization were prospectively randomized to one of the four perfusion protocols: Group 1: Closed and totally hyaluronan based heparin free coated (Vision HFO-GBS-HF, Gish Biomedical, Rancho Santa Margarita, CA) ECC with a soft-shell coated venous reservoir (SVR11S2-HFC, Gish Biomedical) and a hard-shell cardiotomy (CAPVRF44, Gish Biomedical) (n = 12); Group 2: Closed and totally uncoated identical ECC with soft-shell uncoated venous reservoir and a hard-shell cardiotomy (n = 12); Group 3: Open, totally hyaluronan based heparin free coated ECC (n = 12); and Group 4: Control-open, uncoated ECC (n = 12). Blood samples were collected at T1: Baseline; T2: 15 minutes after cardiopulmonary bypass (CPB) initiation; T3: before cessation of CPB; T4: 15 minutes after protamine reversal, and T5: in the intensive care unit. Serum IL-6 levels were significantly lower at T2 in all study groups, at T3 for coated groups, and T4 for closed+coated group (p < .05 versus control). Creatine kinase M-band (MB) levels in coronary sinus blood demonstrated well preserved myocardium after CPB in both coated groups versus Control (p < .05). Neutrophil CD11b/CD18 levels were significantly lower for all study groups versus control at T2, for both coated groups at T3 and only for closed + coated group at T4 (p < .05). Postoperative hemorrhage (mL) was 510 +/- 40 in closed + coated and 536 +/- 40 in open + coated groups (control: 784 +/- 48, p < .05). No significant differences in thrombin-antithrombin complex and free plasma hemoglobin were observed. Desorbed protein amount on ECC (mg/dL) was 1.7 +/- .01 in closed+coated, 2.01 +/- .01 in open+coated, and 3.3 +/- .015 in control groups (p < or = .05). Use of a closed and completely heparin free coated ECC may reduce neutrophil degradation, cytokine release characterized by improved clinical outcomes including reduced blood loss, reduced requirement for inotropes, and reduced atrial fibrillation.