[The specificity of expression of molecular biological markers in tumors of the mammary gland]. / Osobennosti ékspressii molekuliarno-biologicheskikh markerov v opukholiakh molochnoi zhelezy.

Data are described on a retrospective immunohistochemical study of the Ki-67, PCNA, Bcl-2, BAX, BclX and VEGF expression in tumors of two groups of patients with breast cancer (BC) and with the favorable and unfavorable clinical courses. A reliably high level of VEGF expression was detected in tumors of patients with an early BC relapse. Apart from VEGF, higher levels of the Ki-67 and PCNA expression were registered in tumors of the discussed patient's category. It can be suggested that the expression parameters of VEGF, Ki-67 and PCNA in the primary tumor can be made use of in evaluating the BD prognostications or describing the features of high-risk groups with a high probability of early disease relapses.

[A novel marker of multiple drug resistance BCRP]. / Novyi marker mnozhestvennoi lekarstvennoi rezistentnosti--BCRP.

Data on a new marker of multidrug resistance from the group of ABC-transporters--BCRP (breast cancer resistance protein) and in particular the data on the general characteristics of BCRP, spectrum of substrates for this transporter, data on the role of BCRP in human organism, pathways of inhibiting BCRP-dependent transport by pharmacological agents are presented. The data on BCRP expression in human normal tissues and tumor cells are considered in detail. Possible reasons of results inconsistency in evaluation of BCRP expression in different tumors and prognostic significance of BCRP in prediction of sensitivity to chemotherapy and aggressiveness of disease process are discussed.

[Computerized evaluation of the informativeness of radioimmunologic tests in the diagnosis of stomach cancer]. / Komp'iuternaia otsenka informativnosti radioimmunologicheskikh testov dlia diagnostiki raka zheludka.

Solution rules in the form of differential-diagnostic tables with coefficients of weight and threshold values of 16 different signs were obtained with the help of a computer EC-assisted algorithm of a generalized picture. These signs included tumor antigens, cyclonucleotides and hormones determined in the blood serum of healthy individuals, stomach cancer patients and patients with diseases of nonmalignant origin. These signs being of low informative value by themselves, in a combined use provided an opportunity to differentiate between "stomach cancer-not cancer" with a sufficiently high degree of significance.

[Natural antitumor cytotoxicity of the whole blood of donors and cancer patients]. / Estestvennaia protivoopukholevaia tsitotoksichnost' tsel'noi krovi donorov i onkologicheskikh bol'nykh.

Natural antitumor resistance of cancer patients and healthy subjects was studied on the basis of whole blood natural cytotoxicity (WBNC) assay. A correlation between WBNC and mononuclear leukocyte cytotoxic activity in healthy donors was established (r = 0.912; p less than 0.001). WBNC levels in colonic, breast and gastric cancer patients were decreased as compared with healthy controls.

[Cyclic nucleotides in patients with cancer and non-tumoral diseases of the gastrointestinal tract]. / Tsiklicheskie nukleotidy u bol'nykh rakom i neopukholevymi zabolevaniiami zheludochno-kishechnogo trakta.

The intracellular levels of adenosine-3,5-monophosphate and guanosine-3,5-monophosphate were compared in 76 patients with different patterns of stomach pathology and 98 cases of colonic diseases. A significant decrease in concentration of cyclic nucleotides in malignant tumors of the digestive tract was observed. The results point to essential functional changes taking place at cellular level in the grossly intact mucosa of the stomach and colon in tumor pathology.

[Antibodies to Forssman antigen in patients with cancer of the gastrointestinal tract and breast]. / Antitela k antigenu Forssmana u bol'nykh rakom zheludochno-kishechnogo trakta i molochnoi zhelezy.

Blood sera of 103 normal persons, 104 patients with malignant and 33 patients with benign tumors of different sites, 28 patients with inflammatory diseases of the gastro-intestinal tract and female sexual organs were examined to demonstrate antibodies to Forssman's antigen (FA) by means of the microhemagglutination test with sheep red blood cells. It was established that reduction in the amount of antibodies to FA was the most characteristic for gastro-intestinal carcinomas and to a lesser degree for breast cancers and that it was sporadically encountered in normal persons with non-cancerous pathology. The number of patients with low titres of antibodies to FA increased as the cancerous process progressed.