RESUMO
Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system. We present a case of sacroiliitis (a relatively uncommon feature) and sensorimotor demyelinating polyneuropathy, which has been reported previously in only a few cases during isotretinoin therapy. Clinical symptoms were improved after the withdrawal of isotretinoin and the follow-up electrophysiological study performed 2 years after the initial diagnosis of polyneuropathy showed mild improvement. Dermatologists are advised to be alert to symptoms of polyneuropathy and sacroiliitis during treatment with isotretinoin.
Assuntos
Artrite/induzido quimicamente , Doenças Desmielinizantes/induzido quimicamente , Fármacos Dermatológicos/efeitos adversos , Isotretinoína/efeitos adversos , Polineuropatias/induzido quimicamente , Articulação Sacroilíaca/efeitos dos fármacos , Acne Vulgar/tratamento farmacológico , Adulto , Artrite/metabolismo , Doenças Desmielinizantes/diagnóstico por imagem , Fármacos Dermatológicos/administração & dosagem , Relação Dose-Resposta a Droga , Humanos , Isotretinoína/administração & dosagem , Masculino , Polineuropatias/diagnóstico por imagem , Radiografia , Articulação Sacroilíaca/diagnóstico por imagem , Articulação Sacroilíaca/metabolismo , Resultado do Tratamento , Suspensão de TratamentoRESUMO
The temporal lobe agenesis syndrome is a rare congenital abnormality. This syndrome frequently has been described in association with arachnoid cysts or abnormal collections of cerebrospinal fluid. Arachnoid cysts develop most frequently in the middle cranial fossa and almost all these cysts are unilateral. Bilateral middle cranial fossa arachnoid cysts are extremely rare and only 9 cases have been reported in the literature. We present an adult case with bilateral arachnoid cysts and temporal lobe agenesis whose mental examination and neurologic assessment is normal. The cysts are demonstrated by CT and metrizamid CT cysternography.