RESUMO
The objective of this study, is to confirm a clear benefit of protein synthesis after administration of branched amino acids in parenteral nutrition solutions. Particularly, on a parenteral total hypocaloric nutrition including lipids. Eighty one digestive surgical patients, were included in this study. Fifty with neoplastic disease and thirty one without. Patients in both study groups received a similar peripheral vein nutritional support regimen one week after surgical treatment. To evaluate the effects of the branched chain amino acid enrichment on total parenteral nutrition, we observed the behavior of short middle life proteins such as transferrin, prealbumin, and retinol binding protein, for their reliability as indexes of protein synthesis.
Assuntos
Aminoácidos de Cadeia Ramificada/administração & dosagem , Proteínas Sanguíneas/metabolismo , Doenças do Sistema Digestório/terapia , Neoplasias do Sistema Digestório/terapia , Nutrição Parenteral Total/métodos , Terapia Combinada , Doenças do Sistema Digestório/sangue , Neoplasias do Sistema Digestório/sangue , Estudos de Avaliação como Assunto , Humanos , Cuidados Pós-Operatórios/métodosRESUMO
One of the generic indications of parenteral peripheral malnutrition is the immediate postoperative period following surgery of the digestive tract. In the series presented, fifty patients with digestive neoplasia of different locations were studied, with slight or moderate malnutrition upon admittance. After the operation, feeding was done using hypocaloric parenteral solutions for the first seven days of the postop. period. In the qualitative intake of nitrogen in this type of nutrition, branched chain amino acids are important due to their beneficial effects on metabolism, and for this reason two complete hypocaloric solutions containing 45% and 15.5% of these amino acids were administered to each respective group under study. To justify the effect of improving the proteic synthesis attributed to these amino acids, the levels of rapid turnover proteins, transferrin, prealbumin and retinol-binding protein were determined.