Aqueous humor penetration of ofloxacin given by various routes.

We studied the aqueous humor penetration of ofloxacin after topical, oral, and intravenous administration in 51 consecutive patients undergoing cataract surgery. Aqueous humor concentration (mean +/- SD) was 0.53 +/- 0.35 mg/l when ofloxacin 0.3% eyedrops were instilled topically six times, one drop every three hours, until 90 minutes preoperatively, and 0.63 +/- 0.29 mg/l (P = .45) when two additional instillations were made, one drop every 30 minutes, until 30 minutes before aqueous humor aspiration. Aqueous humor concentration two hours after a single 200-mg oral dose (0.38 +/- 0.15 mg/l) was significantly lower (P = .048) than that 12 hours after the same oral dose (0.58 +/- 0.24 mg/l). Two hours following an intravenous infusion of 200 mg of ofloxacin, aqueous humor concentration was 0.33 +/- 0.19 mg/l. Our results suggest that therapeutic levels above the minimum inhibitory concentration for many bacteria cultured in endophthalmitis can be achieved in aqueous humor after either topical or oral administration, which indicates that this antibiotic passes easily through the corneal and the blood aqueous barriers.

[Uveitis complicating posterior segment neovascularization. Six cases]. / Uvéites compliquées d'une néovascularisation du segment postérieur. A propos de 6 cas.

Subretinal or preretinal neovascularisation may be occasionally observed during the evolution of certain forms of uveitis. Subretinal neovascularisation commonly begins at the level of the chorioretinal uveitic scars. Consequently, the alteration of the retinal pigment epithelium-Bruch's membrane-choriocapillaris complex is the apparent cause. Laser photocoagulation of the neovascular front, when indicated, is the treatment of choice. In contrast, preretinal neovascularisation is observed at the active stage of uveitis. Fluorescein angiography findings suggest that it is probably correlated with the importance of inflammation since in most of the cases there is no retinal ischemia. Therefore, in order to obtain a regression of the neovascular tufts the treatment should be directed against the inflammatory process. In this study the authors report five cases of subretinal neovascularisation which developed at the level of chorioretinal post-inflammatory scars and one case of papillary neovascularisation which occurred during the active stage of an unilateral intermediate uveitis and in which new vessels regressed completely following systemic steroid treatment.

[The progeny of the two protan and deutan families described by Franceschetti and Klein (1949, 1956), one generation later. Genealogy, color vision and genomic DNA]. / Le devenir des familles protan + deutan de Franceschetti et Klein (1949 et 1956), une génération après. Généalogie, vision colorée et ADN génomique.

The progeny of the couple of which the husband was protanope and the wife deuteranope (Franceschetti, 1949) has been examined (3 generations) in 1986 and 1987. This couple had 4 children, of which 3 sons are deutan and 1 daughter, a double carrier, is phenotypically normal. This girl, in her turn and in exemplary fashion, has 3 children: 1 daughter, being simple carrier, is phenotypically normal, 1 son is protan and 1 son deutan. The study of the genomic DNA of 3 normal subjects reveals the presence of two genes responsible for green and one gene responsible for red; the genomic DNA of a protanomalous subject shows a modification of the gene for red, while that of two deuteranopes shows absence of genes responsible for green. The descent of the second couple in which the husband was deuteranope and the wife protanope (Franceschetti and Klein, 1956) is exclusively of female sex. Therefore it comprises only phenotypically normal persons.

[Immunosuppressive treatment of Behçet's syndrome. Long-term results]. / Traitement immunodépresseur du syndrome de Behçet. Résultats à long terme.

We present middle and long-term results of cyclophosphamide and procarbazine therapy of Behçet's uveitis. Of 45 patients, 20 were followed for 1-4 years (14 successful cases, 5 satisfactory results with regression of inflammatory signs but no functional improvement, 1 failure), 17 for 5-10 years (9 successes, 5 satisfactory results, 3 failures), and 8 for 11-16 years (2 successes, 2 satisfactory results, 4 failures). The high percentage of success (over 55%) could be attributed partly to the early onset of therapy and may be partly to the choice of drugs.