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1.
An. acad. bras. ciênc ; 89(4): 2833-2841, Oct.-Dec. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-886830

RESUMO

ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.


Assuntos
Animais , Feminino , Ratos , Osteoporose/tratamento farmacológico , Extratos Vegetais/farmacologia , Densidade Óssea/efeitos dos fármacos , Osteoblastos , Osteoporose/induzido quimicamente , Tíbia , Ratos Wistar , Modelos Animais de Doenças , Fosfatase Alcalina/metabolismo , Glucocorticoides
2.
An Acad Bras Cienc ; 89(4): 2833-2841, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29044313

RESUMO

Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.


Assuntos
Densidade Óssea/efeitos dos fármacos , Osteoporose/tratamento farmacológico , Extratos Vegetais/farmacologia , Fosfatase Alcalina/metabolismo , Animais , Modelos Animais de Doenças , Feminino , Ginkgo biloba , Glucocorticoides , Osteoblastos , Osteoporose/induzido quimicamente , Osteoporose/enzimologia , Ratos , Ratos Wistar , Tíbia
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